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Invasion of genomic parasites triggered modern mammalian pregnancy
Date:9/25/2011

Genetic parasites invaded the mammalian genome more than 100 million years ago and dramatically changed the way mammals reproduce -- transforming the uterus in the ancestors of humans and other mammals from the production of eggs to a nurturing home for developing young, a new Yale University study has found.

The findings published online Sept. 25 in the journal Nature Genetics describe in unprecedented detail the molecular changes that allowed mammals to carry their developing young within the safety of the womb rather than laying them in nests or carrying them around in pouches.

"In the last two decades there have been dramatic changes in our understanding of how evolution works," said Gunter Wagner, the Alison Richard Professor of Ecology and Evolutionary Biology (EEB) and senior author of the paper. "We used to believe that changes only took place through small mutations in our DNA that accumulated over time. But in this case we found a huge cut-and-paste operation that altered wide areas of the genome to create large-scale morphological change."

The Yale team studying the evolutionary history of pregnancy looked at cells found in the uterus associated with placental development. They compared the genetic make-up of these cells in opossums marsupials that give birth two weeks after conception to armadillos and humans, distantly related mammals with highly developed placentas that nurture developing fetuses for nine months.

They found more than 1500 genes that were expressed in the uterus solely in the placental mammals. Intriguingly, note the researchers, the expression of these genes in the uterus is coordinated by transposons essentially selfish pieces of genetic material that replicate within the host genome and used to be called junk DNA.

"Transposons grow like parasites that have invaded the body, multiplying and taking up space in the genome," said Vincent J. Lynch, research scientist in EEB and lead author of the paper
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Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

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