Navigation Links
Invasion of genomic parasites triggered modern mammalian pregnancy
Date:9/25/2011

Genetic parasites invaded the mammalian genome more than 100 million years ago and dramatically changed the way mammals reproduce -- transforming the uterus in the ancestors of humans and other mammals from the production of eggs to a nurturing home for developing young, a new Yale University study has found.

The findings published online Sept. 25 in the journal Nature Genetics describe in unprecedented detail the molecular changes that allowed mammals to carry their developing young within the safety of the womb rather than laying them in nests or carrying them around in pouches.

"In the last two decades there have been dramatic changes in our understanding of how evolution works," said Gunter Wagner, the Alison Richard Professor of Ecology and Evolutionary Biology (EEB) and senior author of the paper. "We used to believe that changes only took place through small mutations in our DNA that accumulated over time. But in this case we found a huge cut-and-paste operation that altered wide areas of the genome to create large-scale morphological change."

The Yale team studying the evolutionary history of pregnancy looked at cells found in the uterus associated with placental development. They compared the genetic make-up of these cells in opossums marsupials that give birth two weeks after conception to armadillos and humans, distantly related mammals with highly developed placentas that nurture developing fetuses for nine months.

They found more than 1500 genes that were expressed in the uterus solely in the placental mammals. Intriguingly, note the researchers, the expression of these genes in the uterus is coordinated by transposons essentially selfish pieces of genetic material that replicate within the host genome and used to be called junk DNA.

"Transposons grow like parasites that have invaded the body, multiplying and taking up space in the genome," said Vincent J. Lynch, research scientist in EEB and lead author of the paper
'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

Page: 1 2

Related biology news :

1. UH Manoa researchers release results of statewide survey of snail, slug invasions in Hawaii
2. Invasions by alien plants have been mapped in European Union
3. New method for detection of phosphoproteins reveals regulator of melanoma invasion
4. Master gene SRC-3 enables breast cancer growth, invasion
5. Scientists discover ancient viral invasion that shaped human genome
6. UC Riverside entomologist helps manage invasion threats posed to Californias avocados
7. Defective cell surface glue is key to tumor invasion
8. Tree resin the key evidence of current and historic insect invasions
9. Manage biological invasions like natural disasters, biologists say
10. High-throughput screen finds compounds that regulate cancer cell invasion
11. Open minded and open access: NeoBiota, a new publishing platform for invasion biologists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the ... 2015-2019" report to their offering. ... is the adoption of multimodal biometric systems. Multimodal ... an individual for verification and identification purposes. This ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
(Date:12/5/2014)... Utah , Dec. 4, 2014  Tute Genomics, ... raised $2.3 million in Series A1 funding led by ... investors also participated in the investment round. ... the healthcare community adopts next-generation sequencing and seeks new ... said Reid Robison , MD MBA, and CEO ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... one of the most fundamental processes in the life of ... according to University of Leeds researchers. Arabidopsis thaliana ... cracks in pavements all over Europe and Asia, but the ... rat of the plant world. It has become the ...
... The National Institutes of Health has renewed its ... the Scripps Translational Science Institute (STSI) in the ... years to support innovative research in genomics, wireless ... which is a collaborative program between Scripps Health ...
... In the dog days of summer, female edible dormice ( ... immediately after this energy-intensive period they start to replenish their ... habit seems to give the animals a pleasant taste and ... Romans even kept them in captivity to fatten them up ...
Cached Biology News:Model plant misled scientists about multicellular growth 2Model plant misled scientists about multicellular growth 3NIH awards Scripps Translational Science Institute $29 million grant 2NIH awards Scripps Translational Science Institute $29 million grant 3Fat and fit 2
(Date:12/19/2014)... 18, 2014 Egenix, Inc. is pleased to announce ... of the Board, to succeed Donald Fresne ; Mr. ... continue as a member of the Board.  In recognition of ... the company over almost twenty years, the Board designated Mr. ... Directors has established a Search Committee to find a suitable ...
(Date:12/17/2014)... 16, 2014 The Activated Carbon ... which is why IBISWorld updated its original industry research ... benefit from an intensified focus on environmental policy. Over ... emission standards for power plants and a range of ... IBISWorld Industry Analyst Sarah Kahn, “a range of downstream ...
(Date:12/17/2014)... 17, 2014 Achim Noack has been ... Stoller Group. In this position, Noack will assist Jerry ... matters, develop marketing strategy and supervise global marketing management ... “Achim has tremendous knowledge and experience in the crop ... “His experience and innovative thinking will be a great ...
(Date:12/17/2014)... This report is a professional ... For an overview analysis, the report introduces quartz ... structure, industry overview, policy analysis, and news analysis, ... has witnessed rapid development with key manufacturers increasing ... report mentions quartz tubing upstream raw materials and ...
Breaking Biology Technology:Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 22020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,(TSX: ONC, NASDAQ: ONCY) ... of the Tom Baker Cancer Centre, Calgary, entitled,"Targeting ... at the American Association for Cancer Research (AACR) ... Diego, California from April,12-16, 2008., The presentation ...
... Amylin Pharmaceuticals,Inc. (Nasdaq: AMLN ) will webcast ... 2008 on Monday, April 21, 2008 at 8:30 a.m. ... Executive,Officer, will lead the call. On the same date ... of 2008., The call will be webcast live ...
... Families, EMERYVILLE, Calif., April 15 Alta ... new health care areas designed to,soothe patients and ... offer health resources. The Carol Ann,Read Breast Health ... all in one location, for the quickest turnaround ...
Cached Biology Technology:Oncolytics Biotech Inc. Collaborators Present Reovirus Research for Multiple Myeloma at AACR Annual Meeting 2Amylin Pharmaceuticals to Webcast First Quarter Results 2Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 2Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 3
... The BAS-2500 is ... applications: Molecular Biology (1D ... protein blots, Macroarrays); Pharmacokinetics ... autoradiography, thin layer chromatography); ...
... This microscope is described by end-users ... it incorporates the fundamentals of light microscopy ... and small footprint, it does not require ... in a busy lab environment. The DM-BA300 ...
... BAS-5000 is the highest resolution standard ... top member of Fujifilm's family of ... Imaging Plate (IP) and changeable resolutions ... Fujifilm BAS-5000 does it without compromising ...
This bispecific antibody complex has been tested for efficient depletion of CD41+ cells using the StemSep ; negative immunomagnetic cell separation system....
Biology Products: