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Intruder detected: Raise the alarm!
Date:10/14/2011

cture of RIG-I in the presence and absence of viral RNA, in a technique called X-ray crystallography. They found that in the absence of a viral infection, the receptor is 'sleeping with one eye open': the part of RIG-I that senses viral RNA is exposed, whilst the domains responsible for signalling are hidden, out of reach of the signalling machinery. When RIG-I detects viral RNA, it changes shape, 'waking up' the signalling domains, which become accessible to trigger interferon production. Although the EMBL scientists used RIG-I from the mallard duck, this receptor's behaviour is identical to that of its human counterpart.

"RIG-I is activated in response to viral RNA, but a similar mechanism is likely to be used by a number of other immune receptors, whether they are specific to viruses or bacteria," says PhD student Eva Kowalinski, who carried out most of the work.

Thus, these findings contribute to a broader understanding of the workings of the innate immune system our first line of defence against intruders, and the subject of this year's Nobel Prize in Physiology or Medicine.

The work was carried out within the framework of the International Unit of Virus Host-Cell Interactions, a collaboration between EMBL, the University Joseph Fourier (UJF), in Grenoble, and the French Centre National de la Recherche Scientifique (CNRS) and also involved contributions from the laboratory of Denis Gerlier at the Institut National de la Sant et de la Recherche Mdicale (INSERM), in Lyon, France.


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Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

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