Navigation Links
Intravenous gene therapy protects normal tissue of mice during whole-body radiation
Date:10/28/2007

LOS ANGELES, Oct. 28 Gene therapy administered intravenously could be an effective agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb, according to an animal study presented today by University of Pittsburgh researchers at the 49th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Los Angeles.

Ionizing radiation can be extremely damaging to cells, tissues, organs and organ systems, said Joel S. Greenberger, M.D., professor and chairman, department of radiation oncology, University of Pittsburgh School of Medicine. In previous studies, we demonstrated that gene therapy can be both swallowed in liquid form and inhaled through a nebulizer prior to radiation exposure to protect healthy tissues from damage. In this study, we found that the same therapy administered intravenously also offers protection during exposure to whole-body irradiation. Dr. Greenberger added that intravenous administration could potentially offer wide-reaching protection to the public in the event of a terrorist attack since experts believe a significant number of the population would die within 30 days of receiving a large dose of radiation to the entire body.

In the study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation. The researchers found that in a control group of mice that received an initial 9.5 Gy dose of radiation, 58 percent survived at 30 days compared to 90 percent after the same length of time for an experimental group of mice that were injected with MnSOD-PL prior to irradiation. Between 30 and 330 days, there were no differences in survival rates between experiment and control group mice, indicating that systemic MnSOD-PL treatment was not harmful to survival.

Intravenous administrat
'/>"/>

Contact: Clare Collins
CollCX@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Intravenous gene therapy protects normal tissue of mice during whole-body radiation
2. Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer
3. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
4. Columbia research lifts major hurdle to gene therapy for cancer
5. Combination therapy boosts effectiveness of telomere-directed cancer cell death
6. Gene therapy converts dead bone graft to new, living tissue
7. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
8. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
11. Gene Therapy For Parkinsons Disease Moves Forward In Animals

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2009)...ty-associated strain of the deadly superbug MRSAan...on antibioticsposes a far greater health threat th...pitals, according to a study in the December issue...hreat is easily picked up in fitness centers, scho... overall burden of MRSA within hospitals, the repo...
(Date:11/23/2009)...- The time of day matters to forest trees dealing ... a research team led by Professor Malcolm Campbell...al for research and colleagues in the department o...s. , Capitalizing on their previous work to de...eam examined how poplar trees use their 45,000 gen...
(Date:11/23/2009)...60 participants gathered this week for the seventh... conference. This year,s topic, "Synthetic Biology...ical researchers to explore the engineering, scien...field of synthetic biology. , Bonnie L. Bassler,...rsity and this year,s conference chair, challenged...
Breaking Biology News(10 mins):New study finds MRSA on the rise in hospital outpatients 2Time of day matters to thirsty trees, U of T researcher discovers 2Synthetic biology offers new opportunities for interdisciplinary collaboration 2AHIP Statement on Release of Finance Committee Chairmans Mark 57424 1AHIP Statement on Release of Finance Committee Chairmans Mark 57424 2September 2009 Mayo Clinic Womens HealthSource Highlights Ovarian Cancer Salt and Breaking a Sweat 57422 1September 2009 Mayo Clinic Womens HealthSource Highlights Ovarian Cancer Salt and Breaking a Sweat 57422 2September 2009 Mayo Clinic Womens HealthSource Highlights Ovarian Cancer Salt and Breaking a Sweat 57422 3September 2009 Mayo Clinic Womens HealthSource Highlights Ovarian Cancer Salt and Breaking a Sweat 57422 4September 2009 Mayo Clinic Womens HealthSource Highlights Ovarian Cancer Salt and Breaking a Sweat 57422 5AFSCME President McEntee 3A 22Finance Committee Health Care Bill is Deeply Flawed 22 57421 1
...UC Davis study says that people trying to help nat...ink more naturally. , "Human beings tend to think...nature can be much more irregular," said UC Davis,...,s lead author. "We,found that symmetrical systems...l communities than designs with some randomness or...
...nvironment may play a greater role in the disparit...with hypertension compared to non-Hispanic whites ...hns Hopkins Bloomberg School of Public Health foun...n comparing groups of African Americans and non-Hi...s. The results are published in the November 2008 ...
...LE #1 FOR IMMEDIATE RELEASE , LEDs may help...: American Chemical Society , Researchers in Germ...x and cosmetic surgery for easing facial wrinkles....f ACS, Crystal Growth & Design, a bi-monthly jou...om light emitting diodes (LEDs) applied daily for ...
Other Biology News:Hypertension disparity linked to environment 2American Chemical Society Weekly PressPac Oct. 15, 2008 2American Chemical Society Weekly PressPac Oct. 15, 2008 3American Chemical Society Weekly PressPac Oct. 15, 2008 4American Chemical Society Weekly PressPac Oct. 15, 2008 5American Chemical Society Weekly PressPac Oct. 15, 2008 6American Chemical Society Weekly PressPac Oct. 15, 2008 7American Chemical Society Weekly PressPac Oct. 15, 2008 8
(Date:11/24/2009)...Newswire-FirstCall/--Sigma-AldrichCorporation(Nasd...onTuesday,December1stat1:45PMGMTinLondon,7:45AMUS/...tovertheInternetavailableat http://inve s tor.s...t"icontoaccessthisfile. ,, AboutSigma-Aldrich...logycompany.Itschemicalandbiochemicalproductsandki...
(Date:11/24/2009)...Newswire-Asia/--ShanghaiBiolaxyannouncedthe,Chines...the,investigationalnewdrugapplication(IND)foritsor...lationtotreatdiabetes.ThisIND,approvalallowsBiolax...betesisadisordercharacteristicofhighbloodglucosean...sultinseveremicro-and,macro-vasculardiseases,losso...
(Date:11/24/2009)...PRNewswire-FirstCall/--Shireplc(LSE:SHP,NASDAQ: S...today,announcedthatithassubmittedaMAAtotheEuropean...nzymereplacementtherapyindevelopment,forthetreatme...plicationforvelaglucerasealfathathasbeensubmitted,.... , Basedonaglobalsupplyshortageofthecurrentl...
(Date:11/24/2009)...Chemical Abstracts Service (CAS), the global exper...tent office is now the world,s leading producer of... trailed Japan,s patent office, the World Intellec...States Patent and Trademark Office (USPTO) for mor...O in 2006, and exceeded Japan for the first time o...
Breaking Biology Technology:Biolaxy Secures IND Approval for Oral Insulin 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 3China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 3
...acksburg, Va. -- The ubiquity of mineral nanoparti...ls and their intriguing properties provide Earth s...stand our planet. , So states a team of scientist...he March 21, 2008, issue of Science, Nanominerals,...e way minerals influence earth is more complex tha...
...ebcast and Conference Call Scheduled for Thursday,... ET, TUCSON, Ariz., March 20 ImaRx Therapeuti...Company will host a live,webcast and conference ca...,discuss corporate updates and fourth quarter 2007...ssed through ImaRx,s corporate website at, http://...
...LIS, Md., March 20 PharmAthene, Inc.,(Amex: PIP ...easures against,biological and chemical threats, t...release for the full year ended December 31, 2007.... today, March 20, 2008. PharmAthene,will schedule ...conference,call at a later time., The conference ...
Other Biology Technology:Nanoscience will change the way we think about the world 2Nanoscience will change the way we think about the world 3Nanoscience will change the way we think about the world 4Nanoscience will change the way we think about the world 5ImaRx to Report Corporate Updates and 4Q07 Financial Results 2
...r 211 ] affinity isolated antibody aqueous solut...aline (without Mg 2+ and Ca 2+ ), pH 7.3, with 1....um azide. a synthetic phosphorylated peptide deriv...sine 207 and serine 209 (corresponding to tyrosine...
Max-Power 2000V Power Supply from Major Science
Chicken Anti-Rab GDP dissociation inhibitor beta Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.
Microfluidic Power Supply from Major Science
Biology Products: