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Intranasal neuropeptide Y may offer therapeutic potential for post-traumatic stress disorder
Date:4/21/2013

ion in anxiety, depressive-like behavior and hyper-arousal was reduced in the animals given intranasal NPY, and some of the features were the same as in the animals not exposed to the stress. There was a lower stress triggered rise in plasma stress hormones, such as glucocorticoids and in expression of their receptor in the hippocampus in the NPY treated animals. Intranasal NPY also modulated the response of the brain noradrenergic system to the traumatic stress of SPS.

The results demonstrated, for the first time, that rapid delivery of NPY to the brain by intranasal infusion, before or shortly after exposure to traumatic stress, has a pronounced resilient effect and ameliorates development of PTSD-like symptoms in rats. It provides proof of concept for potential of intranasal NPY for non-invasive prophylactic treatment for individuals likely to be exposed to traumatic stress, such as early responders or military personnel, as well as for early intervention after exposure to traumatic stress.

These research findings will be presented April 21st, 2013 during Experimental Biology 2013 in Boston, MA


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Contact: Jim Bernstein
jbernstein@aspet.org
301-646-3259
Federation of American Societies for Experimental Biology
Source:Eurekalert

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