BOSTON Stress triggered neuropsychiatric disorders take an enormous personal, social and economic toll on society. In the US more than half of adults are exposed to at least one traumatic event throughout their lives. Post-traumatic stress disorder (PTSD) is a debilitating anxiety disorder associated with exposure to a traumatic event outside the range of normal human experience. PTSD typically follows a chronic, often lifelong, course. Patients have diminished quality of life, are more likely to manifest other psychiatric disorders such as depression and six times more likely as demographically matched controls to attempt suicide. Prevention and treatment of PTSD remains a challenge with improved therapies needed to help save billions of dollars in medical care and provide enormous society benefit.
Based on a variety of studies in humans and animals it has been suggested that neuropeptide Y (NPY), a peptide that acts as a neurotransmitter in the brain, has therapeutic potential for PTSD. This naturally occurring peptide is one of the widely expressed inside and outside of the brain with diverse functions. Human studies indicate that NPY is associated with resilience to development of PTSD or helps improve recovery from harmful effects of traumatic stress. Injections into the brain of rodents attenuated some of the behavioral responses related to stress associated neuropsychiatric disorders. However systemic administration of NPY will likely have undesirable side effects, especially on the cardiovascular system.
This study delivered NPY to rats by intranasal infusion, a non-invasive procedure to bypass the blood brain barrier. A single infusion was administered 30 min before or immediately after exposure to single prolonged stress (SPS). Behavioral, neuroendocrine and biochemical analyses were performed 1 to 3 weeks after SPS and compared to untreated controls or to animals infused with the solution without NPY. The SPS-elicited elevat
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Federation of American Societies for Experimental Biology