Navigation Links
Intracellular express -- why transport protein molecules have brakes
Date:5/21/2010

Every single one of our cells contains so-called motor proteins that transport important substances from one location to another. However, very little is known about how exactly these transport processes occur. Biophysicists at the Technische Universitaet Muenchen (TUM) and Ludwig Maximilians Universitaet Muenchen (LMU) have now succeeded in explaining fundamental functions of a particularly interesting motor protein. They report their findings in the current issue of the Proceedings of the National Academy of Sciences (USA).

Motorized transport proteins are one of the keys to the development of higher organisms. It is they that enable the cell to transport important substances directly and quickly to a specific location in the cell. As bacteria cannot do this, they are not able to form larger cells or even large organisms with many cells. Particularly important are fast transport proteins in the primary cilia, the cell's antennas, with which they channel information from the surroundings into the cell.

Like trucks on a highway, kinesins transport cellular cargoes to their destinations. They do this by crawling along protein fibers, so-called microtubules, which extend through the entire cell. Kinesins consist of two long intertwined protein chains. At one end of every protein there is a head that can attach itself to certain structures on the surface of the microtubules; the freight is attached to the other end.

Very special kinesins are at work in the cilia of the Caenorhabditis elegans nematode: They consist of two different protein chains and are therefore especially suitable for investigating the transport mechanisms. As freight, the researchers attached small plastic beads to the ends of these motor proteins. They can manipulate these beads with "optical tweezers," a specially formed laser beam.

One end of the protein molecule was held with the optical tweezers; the other was able to walk on microtubules. This
'/>"/>

Contact: Patrick Regan
regan@zv.tum.de
49-892-891-0515
Technische Universitaet Muenchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tel Aviv University President Co-authors Important Paper Unraveling the Effect of Spatial Organization on Intracellular Chemistry
2. Tolerance to inhalants may be caused by changes in gene expression
3. Unique pattern of gene expression can indicate acetaminophen overdose
4. Powerful integration of lipid metabolic profiling with gene expression analysis
5. Mars Express -- 5000 orbits and counting
6. Nucleonics initiates hepatitis B clinical trial with expressed interfering RNA therapeutic
7. Venus Express reboots the search for active volcanoes on Venus
8. Gene-environment interaction in yeast gene expression
9. Scientists discover small RNAs that regulate gene expression and protect the genome
10. Predicting acute GVHD by gene expression could improve liver stem cell transplant outcomes
11. Conaway Lab identifies novel mechanism for regulation of gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014 The Defense ... it easier to detect and prevent counterfeit microcircuits ... Today the agency started performing an in-house microcircuit ... validate the authenticity of purchased microcircuits while increasing ... quality control measures will be conducted at DLA,s ...
(Date:12/17/2014)... Dec. 16, 2014  Automation is fundamentally transforming ... evident than at international borders. Over the past ... have allowed veteran travelers to self process through ... (APC) Kiosks at an increasing number of airports, ... According to Maxine Most , ...
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays a ... while. Hypertension – the medical term for high blood pressure ... 1800s, and the inflatable cuff that,s used in measuring blood ... mean there,s nothing new about hypertension, its triggers and its ... about the condition and the best ways to treat it. ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... Calif. Models of carbon dioxide in the world,s oceans ... UC Irvine and other scientists published online Sunday in ... surface of warm waters are far more carbon-rich than ... fluctuations could mean that tiny Prochlorococcus and ...
... in unhealthy eating behaviors may cause women who are ... worsening of their moods, according to Penn State researchers. ... their eating behaviors reported that moods worsened after bouts ... the Survey Research Center. "There was little in the ...
... tooth. Research from North Carolina State University shows that the ... sweet, soft fruit giving us new insight into a ... past four years and threatens to cause hundreds of millions ... we know that D. suzukii prefers softer, sweeter ...
Cached Biology News:Ocean plankton sponge up nearly twice the carbon currently assumed 2Unhealthy eating can make a bad mood worse 2Study offers new insights on invasive fly threatening US fruit crops 2
(Date:12/17/2014)... Calif. , Dec. 17, 2014 ... a Phase 2 study evaluating the investigational oral ... of patients with severe, chronic itch who are ... of care, including topical steroids and antihistamines. ... change in Visual Analog Scale (VAS) itch score ...
(Date:12/15/2014)... & PETACH TIKVAH, Israel , ... BCLI ), a leading developer of adult ... wholly-owned subsidiary Brainstorm Cell Therapeutics Ltd. was awarded a ... Office of the Chief Scientist (OCS).  This ... receipt of grant support from the Office of the ...
(Date:12/15/2014)... Agritech Limited (NASDAQ GS: SEED) (" Origin ", or the ... China , today announced that the Company ... 30, 2014, before the market opens on Thursday, January 8, ... January 8, 2015, at 8:00 a.m. ET / 9:00 p.m. ... To participate in the call, please dial +1-888-346-8982 in ...
(Date:12/13/2014)... 12, 2014 /CNW/ - MaRS and Virgin Unite Canada, the ... have joined forces to support Canadian entrepreneurs tackling social and ... Founder was at the MaRS Centre to announce the new ... venture fund. This fund has $1 million in seed capital ... -based Mindset Social Innovation Foundation, founded by Alison ...
Breaking Biology Technology:Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3MaRS and Virgin Unite partner to invest in business as a force for good 2MaRS and Virgin Unite partner to invest in business as a force for good 3
... the first time, scientists have shown that amniotic fluid ... potential new source of stem cells for therapeutic applications. ... in Blood , the official journal of the ... other scientists, our research team wondered whether stem cells ...
... Biomedical, Inc., a leader in human embryonic stem cell ... validated kit to produce induced pluripotent stem cells with ... (Logo: http://www.newscom.com/cgi-bin/prnh/20080819/CLTU003LOGO )In ... will launch the complete and fully validated induced pluripotent ...
... 31 Intrinsic Bioprobes, Inc. today announced the ... Institute to develop effective technologies for accurate measurement ... capabilities by effectively discerning diseased from non-diseased states. ... $1,276,360, out of which $1,130,272 is Federal money ...
Cached Biology Technology:Amniotic Fluid May Provide New Source of Stem Cells for Future Therapies 2Amniotic Fluid May Provide New Source of Stem Cells for Future Therapies 3ArunA Biomedical Announces Co-development of Fully Validated Induced Pluripotent Stem Cell Kit 2Intrinsic Bioprobes, Inc. Enters into a $1.27M Contract with the National Cancer Institute to Develop Multiplex Mass Spectrometric Immunoassays for Detection of Low Abundance Cancer-Related Proteins 2
... corresponding to the third cytoplasmic loop of ... to KLH. The immunizing peptide has 79% ... Physical form: Solution in phosphate buffered ... Titertest method: IHC (p). Titertest ...
Canine Chondrocytes (CnC) (500,000 cells)...
... Fluorescein 6-Fam, Hex, Tet Cy3, ... Fluorescein Tamra Black Hole Quenchers Molecular ... Tet Tamra, Joe 3 Dabcyl ... New York Double labelled probes are purified ...
... Varioskan is a high performance spectral ... and incubator. With the advanced SkanIt ... reliability for drug discovery assay development. ... fluorescence intensity, time-resolved fluorescence and photometric ...
Biology Products: