CHICAGO, Ill. (March 28, 2011)Interventional radiologists have completed the first human randomized controlled trial of therapeutic renal denervation or RDNa procedure that uses a catheter-based probe inserted into the renal artery that emits high-frequency energy to deactivate the nerves near the kidneys (or in the renal artery) that are linked to high blood pressure. The researchers say these results confirm that RDN may be an effective therapy for reducingand consistently controllingresistant hypertension when current medications have failed. The results were presented at the Society of Interventional Radiology's 36th Annual Scientific Meeting in Chicago, Ill.
"Renal denervation, a minimally invasive, effective treatment, appears to be safe in the short term with a low incidence of local complications. Its efficacy to lower blood pressure in patients with resistant high blood pressure will be better evaluated with the results of a subsequent trial," said Marc R. Sapoval, M.D., Ph.D., professor of clinical radiology and chair of the cardiovascular radiology department at Hpital Europen Georges-Pompidou in Paris, France. "After six months, 39 percent of patients receiving the endovascular denervation treatment had reached the recommended blood pressure level and, overall, 50 percent of patients showed a measurable benefit of the intervention," he added.
"It is estimated that one in every four American adults has high blood pressure. High blood pressure increases the risk of heart and/or kidney disease and stroke because it makes the heart work too hard," Sapoval explained. "The renal sympathetic system, which are the small nerves that carry the signal from the brain to the kidney and back from the kidney to the brain, plays an important role in the regulation of blood pressure levels. The disruption of these nerve fibers has a positive effect on blood pressure levels," he continued.
"Given its impact on the central sympathetic
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Society of Interventional Radiology