Navigation Links
Interventional radiologists provide hope in delaying growth, spread of breast cancer
Date:3/29/2011

CHICAGO, Ill. (March 29, 2011)The growth and spread of breast cancer tumors may be delayed with a promising treatment that combines two innovative strategies: blocking the enzyme needed to "energize" cancer cells and infusing a potent drug directly into the tumor, with minimum exposure to healthy tissues, indicate researchers at the Society of Interventional Radiology's 36th Annual Scientific Meeting in Chicago, Ill.

"Once breast cancer metastases have been detected, current treatments (such as surgical resection or tumor removal) may be ineffective. We've found a way to keep a breast cancer tumor dormantthus potentially increasing the likelihood that a tumor can be treated successfully," noted Jeff H. Geschwind, M.D., FSIR, professor of radiology, surgery and oncology and director of vascular and interventional radiology at Johns Hopkins University School of Medicine in Baltimore, Md. "Our study shows that an ultrasound-guided intra-tumoral treatment with a drug called 3-bromopyruvate (3-BrPA) may be a very promising new therapy for patients with breast cancer that delays tumor growth and spread," added Geschwind, who is also the director of the Interventional Radiology Center at Johns Hopkins University School of Medicine.

"Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women in the United States," said Geschwind. It was estimated that 207,090 women would be diagnosed withand 39,840 women would die ofcancer of the breast in 2010thus affecting one in eight women during their lives. "The development of new treatment options for this lethal disease is imperative," said Geschwind, indicating that once metastasis is detected, a patient may have (on average) only 18 to 24 months to live.

Increased awareness and screening has increased the likelihood of diagnosing early-stage cancer tumors, and breast cancer is treated in several ways, depending on the kind of breast cancer and how far it has spread, said Geschwind. "However, a significant number of patients experience treatment failure, developing local tumor recurrence or metastatic disease after an initial response to treatments (like chemotherapy and radiation)," he explained. "Metastatic spread may occur in 50 percent of cases with apparently localized breast cancer, and nearly 30 percent of patients with lymph node-negative disease will develop distant metastases within five yearsunderlining the importance of the development of novel, targeted, minimally invasive treatment strategies for tumor control and prevention," he added.

In animal studies, the research team has shown how interventional radiologists are uniquely positioned to combine their basic science knowledgein this case resulting in the exploitation of tumor metabolism as a target for breast cancer therapywith their vast experience in minimally invasive treatment strategies. "Breast tumor cells depend on a metabolic pathway called glycolysis to generate the energy required for their malignant growth. By inhibiting a specific enzyme with the anti-glycolytic agent 3-BrPA, the energy production required for tumor cell growth and spread is blocked," said Geschwind. "Disrupt glycolysis and cancer cells are unable to produce enough energy to survive," he said.

The researchers were then able to maximize the amount of drug delivered to a tumor by infusing the potent drug directly into the tumorusing imaging to guide themand minimizing exposure of healthy tissue to the therapy, explained Geschwind. "The biological targeting abilities of anti-glycolytic treatment combined with an image-guided minimally invasive delivery strategy is a promising approach to reducing the growth and spread of breast cancer in patients," he emphasized.

"In our study, a statistically significant difference in tumor volume was observed. Our results support the continuing development of this highly innovative interventional radiology approach for the safe and effective treatment of breast cancer," he added. "Before we can test our novel treatment strategy in individuals with breast cancer, it is important to perform additional animal studies of a larger size to confirm the efficacy of the treatment and to verify that there are no toxic effects on the normal tissues," noted Geschwind.


'/>"/>

Contact: Maryann Verrillo
mverrillo@sirweb.org
703-460-5572
Society of Interventional Radiology
Source:Eurekalert  

Related biology news :

1. Register now for the Society of Interventional Radiologys 34th Annual Scientific Meeting
2. Society of Interventional Radiology hosts 34th annual scientific meeting
3. Oh baby, interventional radiology makes childbirth safer
4. Interventional treatment can be recommended as first-line treatment for silent killer
5. Interventional radiology: From sidelines to mainstream for patients
6. Society of Interventional Radiology Foundation awards $191,000 in grants
7. Journal of Vascular and Interventional Radiology: New patient radiation safety guidelines
8. Avoiding hysterectomy: Major interventional radiology E-collection info available
9. Journal of Vascular and Interventional Radiology increases impact, international reach
10. Top interventional radiologists, neurointerventionists explore stroke care through CLOTS
11. Press registration open for Society of Interventional Radiology’s 35th Annual Scientific Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Interventional radiologists provide hope in delaying growth, spread of breast cancer
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
Breaking Biology News(10 mins):
(Date:6/27/2016)...   Ginkgo Bioworks , a leading organism ... today awarded as one of the World Economic ... most innovative companies. Ginkgo Bioworks is engineering biology ... world in the nutrition, health and consumer goods ... customers including Fortune 500 companies to design microbes ...
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... 23, 2016  The Prostate Cancer Foundation (PCF) is pleased to ... faster cures for prostate cancer. Members of the Class of 2016 were selected ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: