Navigation Links
Interrupting death messages to treat bone disease
Date:9/6/2010

A surface molecule on bacteria that instructs bone cells to die could be the target for new treatments for bone disease, says a scientist speaking at the Society for General Microbiology's autumn meeting today.

Blocking the death signal from bacteria could be a way of treating painful bone infections that are resistant to antibiotics, such as those caused by Meticillin-resistant Staphylococcus aureus (MRSA).

Bone disease, or osteomyelitis, affects 1 in 5,000 people around the world. It can occur at any stage in life and attack any bone in the body, where it leads to progressive bone destruction.

Osteomyelitis is usually caused by the bacterium Staphylococcus aureus that lives commonly on human skin and in the nose. It can reach the bones through open wounds or during surgery and most often causes infections in people with compromised immune systems.

Research led by Dr. Steve Kerrigan from the Royal College of Surgeons in Ireland in collaboration with Trinity College Dublin has revealed that the ability of S. aureus to latch onto bone cells depends on a specific protein called Spa, which is presented on the bacterium's surface. Once attached to the bone cell, the bacteria transmit signals prompting the bone cell to commit suicide. This causes a gradual loss of bone cells leading to progressive bone destruction and weakening of the skeletal system.

Ms Tania Claro who is presenting the group's work explained how the group's findings could lead to new therapies for osteomyelitis. "Bacteria that do not have the Spa protein on their surface are unable to bind to bone cells, which prevents them from sending suicide messages," she said. "Blocking bacterial attachment to cells via Spa could therefore be a way of treating osteomyelitis, or even preventing it in the first place."

Therapies that could effectively prevent and/or treat osteomyelitis could greatly improve the quality of life of sufferers. "This disease is very painful for patients and frustrating for both them and their doctors." explained Ms Claro. Current treatment involves prolonged aggressive antibiotic therapy, however this approach is often less than successful and surgical debridement is required.

New treatments for the disease that do not rely on existing antibiotics would be advantageous. "The danger of invasive bacterial disease is compounded by the rapid emergence of multi-drug resistant bacteria worldwide," explained Ms Claro. "The findings of this study will help develop better diagnostic tools and treatments for osteomyelitis that will not over-rely on antibiotics."


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

Related biology news :

1. Breast cancer cells recycle to escape death by hormonal therapy
2. Genes that control cell death fingered in age-related hearing loss
3. Caltech geobiologists discover unique magnetic death star fossil
4. Forced evolution: Can we mutate viruses to death?
5. Drops in blood oxygen levels may be key to sudden death in some epilepsy patients
6. New technology aims to reduce maternal and neonatal deaths
7. Fewer deaths with preventive antibiotic use
8. Burnham researchers discover on switch for cell death signaling mechanism
9. Study helps explain connection between sleep apnea, stroke and death
10. Stroke Belt deaths tied to non-traditional risk factors
11. Jefferson scientists discover a key protein regulator of inflammation and cell death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... Das DOTM (Department ... hat ein 44 Millionen $-Projekt ... einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an Decatur ... Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale Anbieter ... aber Decatur wurde als konformste und innovativste ...
(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software ... State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , ... Tremblay, President and COO of STACS DNA. “In further expanding our capacity as a ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
Breaking Biology Technology: