Navigation Links
International team uncovers new genes that shape brain size, intelligence
Date:4/15/2012

is study, Project ENIGMA researchers measured the size of the brain and its memory centers in thousands of MRI images from 21,151 healthy people while simultaneously screening their DNA.

"Earlier studies have uncovered risk genes for common diseases, yet it's not always understood how these genes affect the brain," explained Thompson. "This led our team to screen brain scans worldwide for genes that directly harm or protect the brain."

In poring over the data, Project ENIGMA researchers explored whether any genetic variations correlated to brain size. In particular, the scientists looked for gene variants that deplete brain tissue beyond normal in a healthy person. The sheer scale of the project allowed the team to unearth new genetic variants in people who have bigger brains as well as differences in regions critical to learning and memory.

When the scientists zeroed in on the DNA of people whose images showed smaller brains, they found a consistent relationship between subtle shifts in the genetic code and diminished memory centers. Furthermore, the same genes affected the brain in the same ways in people across diverse populations from Australia, North America and Europe, suggesting new molecular targets for drug development.

"Millions of people carry variations in their DNA that help boost or lower their brains' susceptibility to a vast range of diseases," said Thompson. "Once we identify the gene, we can target it with a drug to reduce the risk of disease. People also can take preventive steps through exercise, diet and mental stimulation to erase the effects of a bad gene."

In an intriguing twist, Project ENIGMA investigators also discovered genes that explain individual differences in intelligence. They found that a variant in a gene called HMGA2 affected brain size as well as a person's intelligence.

DNA is comprised of four bases: A, C, T and G. People whose HMGA2 gene held a letter "C" instead of "
'/>"/>

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Large international study finds memory in adults impacted by versions of 4 genes
2. International Polar Year conference: From knowledge to action
3. Ultracold matter technology from CU and SRI International licensed to Boulders ColdQuanta
4. Comments by the International Scientific Forum on Alcohol Research
5. Public health experts to hold international conference on black health in the Western Hemisphere
6. Scripps Research alumnus wins International Science and Engineering Visualization Challenge
7. New international Ph.D. program on Dynamics of Gene Regulation, Epigenetics and DNA Damage Response
8. Important international collaboration with University of Guam researcher
9. Biophysical Society Announces winners of 2012 International Relations Committee travel awards
10. Registration for the XIX International AIDS Conference (AIDS 2012) opens Dec. 1
11. International team to drill beneath massive Antarctic ice shelf
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has announced the ... Apple/AuthenTec TMDR92 & Sapphire - Technology Report" report ... Following the acquisition of AuthenTec in ... the iPhone 5S. It is currently the only device ...
(Date:12/17/2014)... Va. , Dec. 15, 2014 The Defense ... easier to detect and prevent counterfeit microcircuits from entering ... started performing an in-house microcircuit anti-counterfeit initiative dubbed DNA ... microcircuits while increasing their reliability throughout the supply chain. ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ( ... "Global Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used for the ... facial feature of a person such as nose, jaw ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... mediates the body's defense against a wide variety of infectious ... as the result of a new study by researchers at ... "Essentially, we found a way to grease the gears that ... Selma and Herman Seldin Professor of Medicine and director of ...
... expression of a special green-algae gene into neurons ... have been able to elicit specific behavioral responses ... work paves the way for better understanding of ... muscles, to regulate behavior in intact, living organisms. ...
... In a surprise twist that recalls the film classic "Flowers ... statins, a popular class of cholesterol drugs, to reverse the ... disabilities. The Nov. 8 issue of Current Biology reports ... the disease, called neurofibromatosis 1 (NF1). , The ...
Cached Biology News:Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects 2Algal protein in worm neurons allows remote control of behavior by light 2Recreating 'Flowers for Algernon' with a happy ending 2Recreating 'Flowers for Algernon' with a happy ending 3
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to the ... consultants, Protocol Networks has recently announced its expansion into ... his company has attracted several clients in The Constitution ... as others. With the success of these engagements, Rogers ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
(Date:1/22/2015)... Switzerland (PRWEB) January 22, 2015 Selexis ... characterized mammalian Research Cell Banks (RCBs) used for drug ... Research Cell Banks will include Next-Generation Sequencing ... genetic architecture de-risks biologic manufacturing by ensuring the integrity ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, Inc., ... Inc. (NASDAQ: SQNM ), the leading ... for next generation noninvasive prenatal tests (NIPT). Through ... technology, called Mantis™, to advance analysis of clinically-relevant ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 23D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... CHAPEL HILL, N.C., June 18 To thrive ... need to,understand that a winning sales performance doesn,t ... their sales forces, then,measure the forces, field-performance to ... research study reveals that best-in-class,companies allow their sales ...
... Arsenal Against ... Chronic Wounds, ... provider of advanced wound care products,announced today that its key product, ... by clinicians at Georgetown,University Hospital,s Wound Center to save a patient,s ...
... Pharmaceuticals, Inc., a,privately held biopharmaceutical company specializing in ... ophthalmology, is pleased,to announce the appointment of Dr. ... "I am honored and delighted to join ... as it advances its lead programs through,clinical trials ...
Cached Biology Technology:Increasing Sales Productivity Through Superior Sales Force Performance Management 2Derma Sciences MEDIHONEY(TM) Helps to Save Patient's Limb 2Derma Sciences MEDIHONEY(TM) Helps to Save Patient's Limb 3Derma Sciences MEDIHONEY(TM) Helps to Save Patient's Limb 4Barrett Katz, MD, MBA, Named CEO of Danube Pharmaceuticals 2Barrett Katz, MD, MBA, Named CEO of Danube Pharmaceuticals 3