Navigation Links
International team tracks clues to HIV
Date:5/19/2009

y a very strong binding effect. The problem is, it's not the perfect unit." The objective was to find an existing fullerene derivative molecule that could be easily modified to become the perfect unit.

Rice got involved, he said, "because we make the molecules and the other guys had a great method for in-silico testing of molecules. They approached us and said, 'Do you think we could use some of these?' Then we started bouncing ideas around.

"We began thinking about a very simple experiment to calculate the binding efficiency of a molecule in the HIV pocket, then calculate that for a series of molecules, decide which one is best, make that molecule in real life and see if it correlates," Barron said. "If it does, then you've got a way to design your ultimate molecule. Our work was the first step in the process."

In fact, through their "in-silico," or computer-based, calculations, they found two good fits among the fullerene derivatives tested and are now working to enhance their binding properties to get that perfect molecule, one that sticks "like Velcro" to the virus and can be fine-tuned for various strains.

"This is just one component of the problem -- we're not going to cure HIV," Barron cautioned. The hope, he said, is to develop a method for the rapid creation of drugs to address various strains of HIV and other diseases.

Authors of the paper with Barron were Manthos Papadopoulos of the National Hellenic Research Foundation, Athens; Serdar Durdagi of the National Hellenic Research Foundation and the Freie Universitat, Berlin; Claudiu Supuran of the University of Florence, Italy; T. Amanda Strom, Nadjmeh Doostdar and Mananjali Kumar of Rice; and Thomas Mavromoustakos of the National Hellenic Research Foundation and the University of Athens.

The impromptu nature of the project intrigued Barron as much as the subject itself. "Here you've got computational people, experimental people, synthesis people, cha
'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo
2. ESMO International Symposium on Immunology
3. Conservation International and Toyota partner to protect Philippines rain forests
4. International team shows mercury concentrations in fish respond quickly to increased deposition
5. International team shows mercury concentrations in fish respond quickly to increased deposition
6. BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo
7. Youngstown, Ohio Police Award Mobile Data Contract to BIO-key(R) International
8. Clemson physicist addresses international forum on thermoelectric energy
9. US launch of international consultation for new responsible nanocode
10. International team of scientists warns of climate changes impact on global river flow
11. BIO-key International Showcasing Innovative Public Safety Solutions at 2007 IACP Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)...  Through a well-rounded UAS delegation representing private industry, government, ... showing at AUVSI,s Unmanned 2015 conference last week in ... UAS industry met with over 200 hundred people ... the UAS ecosystem. "Our message is clear ... Aerospace Rich Knoll . "If you want to fly ...
(Date:5/10/2015)... , May 11, 2015 Fingerprint ... sensors FPC1025 and FPC1155 from the distributor World Peace Industrial ... FPC,s distributors in Asia . Deliveries are ... will be used by smartphone manufacturers in China ... in the communicated revenue guidance of + 1 000 MSEK for ...
(Date:5/7/2015)... May 7, 2015 Fingerprint ... FPC1022 and FPC1035, FPC,s smallest touch fingerprint sensors ... mainly considered for integration on the backside of ... OEMs increased possibilities to integrate touch fingerprint sensors ... also improves possibilities for module manufacturers to customize ...
Breaking Biology News(10 mins):Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... 16, 2007)Scientists have determined for the first time the ... detail how genes evolved their functions. "Never before ... time," said project leader Joe Thornton, an evolutionary biologist ... see the precise mechanisms by which evolution molded a ...
... has been found to produce smaller, less nourishing eggs ... birds that provide child-care assistance. This unique adaptation ... often than females without helpers. The research, led ... front cover of Science. In many animal species, ...
... learn and remember" Are memories recorded in a stable ... clay tablet" Prof. Yadin Dudai, Head of the ... that view. They recently discovered that the process of ... miniature molecular machine that must run constantly to keep ...
Cached Biology News:Scientists retrace evolution with first atomic structure of an ancient protein 2Scientists retrace evolution with first atomic structure of an ancient protein 3Mother's little helpers 2Memory machine 2
(Date:5/26/2015)... Regenestem Network has announced the grand opening ... Argentina. The clinic will be lead by Silvina Pastrana, ... a multidisciplinary team of medical professionals who specialize in ... office. , The new Regenestem Network members plan ... in cellular therapies, and establish Regenestem protocols to isolate ...
(Date:5/26/2015)... 2015 Innovacyn, a leader in ... human and animal health industries, announced today the ... of Agriculture College Scholarship Award. The scholarship was ... a passionate commitment to the agriculture industry through ... winners, Alexis Pedrow from Anderson County Jr/Sr High ...
(Date:5/26/2015)... and HILDEN, Germany ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime ... its QIAGEN Clinical Insight ® (QCI™) bioinformatics ... to interpret and report on genomic variants identified ... applications for the bioinformatics platform are in oncology, ...
(Date:5/26/2015)... , May 26, 2015   Intrexon Corporation (NYSE: ... that Gregory Frost , Ph.D., Senior Vice President and ... 2015 Global Healthcare Conference on Wednesday, June 3 rd , ... New York City . About ... is Powering the Bioindustrial Revolution with Better DNA ™ ...
Breaking Biology Technology:Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 2Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 3Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 2QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 4QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 5Intrexon to Present at the Jefferies 2015 Global Healthcare Conference 2
... overwhelming perspective on the biotech industry that says it has ... pump billions of research dollars without any return. As we ... trade on earnings like Big Pharma companies; they trade on ... 2005 sales and earning results are still not out for ...
... materials used to display information on cell phones, monitors ... report in real time on the differentiation of embryonic ... which embryonic stem cells gradually turn into function-specific types ... heart or brain cells. , ,The main challenge facing ...
... Can a Mac really be hacked in just 30 minutes? ... systems engineer, who criticized recent media reports for sensationalism after they ... of a computer gave out login accounts to potential hackers. , ... had been given access to the computer to take full control ...
Cached Biology Technology:The world's leading biotech companies 2The world's leading biotech companies 3Liquid crystals show promise in controlling embryonic stem cells 2
... CE-based system provides clear advantages over ... load, gene expression), mutation analysis, and ... system with microplate connectivity is ideal ... quality control. The P/ACE Series ...
The imaging screen-K (Kodak), tritium, is a 20 x 25 cm storage phosphor screen that is used for the quantitation and imaging of 32P, 33P, 35S, 14C, and 3H....
The optional fixed lens, 105 mm, is for use with the VersaDoc imaging systems for imaging small samples at high resolution....
The filter 640DF35 for the Molecular Imager FX is a band pass filter for Texas Red dye....
Biology Products: