Navigation Links
International team tracks clues to HIV
Date:5/19/2009

y a very strong binding effect. The problem is, it's not the perfect unit." The objective was to find an existing fullerene derivative molecule that could be easily modified to become the perfect unit.

Rice got involved, he said, "because we make the molecules and the other guys had a great method for in-silico testing of molecules. They approached us and said, 'Do you think we could use some of these?' Then we started bouncing ideas around.

"We began thinking about a very simple experiment to calculate the binding efficiency of a molecule in the HIV pocket, then calculate that for a series of molecules, decide which one is best, make that molecule in real life and see if it correlates," Barron said. "If it does, then you've got a way to design your ultimate molecule. Our work was the first step in the process."

In fact, through their "in-silico," or computer-based, calculations, they found two good fits among the fullerene derivatives tested and are now working to enhance their binding properties to get that perfect molecule, one that sticks "like Velcro" to the virus and can be fine-tuned for various strains.

"This is just one component of the problem -- we're not going to cure HIV," Barron cautioned. The hope, he said, is to develop a method for the rapid creation of drugs to address various strains of HIV and other diseases.

Authors of the paper with Barron were Manthos Papadopoulos of the National Hellenic Research Foundation, Athens; Serdar Durdagi of the National Hellenic Research Foundation and the Freie Universitat, Berlin; Claudiu Supuran of the University of Florence, Italy; T. Amanda Strom, Nadjmeh Doostdar and Mananjali Kumar of Rice; and Thomas Mavromoustakos of the National Hellenic Research Foundation and the University of Athens.

The impromptu nature of the project intrigued Barron as much as the subject itself. "Here you've got computational people, experimental people, synthesis people, cha
'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related biology news :

1. BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo
2. ESMO International Symposium on Immunology
3. Conservation International and Toyota partner to protect Philippines rain forests
4. International team shows mercury concentrations in fish respond quickly to increased deposition
5. International team shows mercury concentrations in fish respond quickly to increased deposition
6. BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo
7. Youngstown, Ohio Police Award Mobile Data Contract to BIO-key(R) International
8. Clemson physicist addresses international forum on thermoelectric energy
9. US launch of international consultation for new responsible nanocode
10. International team of scientists warns of climate changes impact on global river flow
11. BIO-key International Showcasing Innovative Public Safety Solutions at 2007 IACP Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... (NLST) investigators also conclude that the 20 percent ... tomography (LDCT) versus chest X-ray (CXR) screening previously ... at experienced screening centers in the United States. ... with their patients about the benefits and risks ... in the New England Journal of Medicine ...
(Date:5/22/2013)... streamlined approach to genetic engineering drastically reduces the ... into bacteria, the workhorses of biotechnology, scientists are ... Biology , the method paves the way for ... development, environmental cleanup and other activities. , Keith ... a piece of the genetic material DNA into ...
(Date:5/22/2013)... 2013 Early screening for prostate cancer could become ... for women, thanks to UC Irvine research published today ... . , After more than a decade of work, ... identify clinically usable markers for prostate cancer in urine, ... with greater accuracy and at dramatically lower cost. The ...
Breaking Biology News(10 mins):NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 2NLST: CT detects twice as many lung cancers as X-ray at initial screening exam 3UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3
... Think globally, act locally makes for a nice bumper sticker ... global climate change? Can local actions make a difference in ... short answer is no, according to the Intergovernmental Panel on ... effects of global drivers; therefore, our local policies must focus ...
... Mass.--High oil prices, energy security considerations and fears about ... sources like biofuels, which burn cleanly and can be ... catches, particularly regarding biofuels like corn-based ethanol: the more ... available for fooda reality that partly accounts for the ...
... the food vs. fuel debate and talk of the various ... Fales, a professor of agronomy and a member of the ... and moderated a three-hour symposium on Friday, Feb. 15, at ... of Science in Boston. The title of the discussion ...
Cached Biology News:Adapting local ecosystems can soften impact of global climate change 2MIT professor to discuss future of biofuels 2Iowa Staters talk biofuels, healthy oils and 'pharma crops' at AAAS meeting 2
(Date:5/23/2013)... , May 23, 2013  Rahal Letterman Lanigan ... human cord blood stem cell banking and therapeutics, announced ... the No. 16 Acorn Stairlifts Indy car driven by ... the remainder of the IZOD IndyCar 2013 season.   ... will work to support awareness of umbilical cord blood ...
(Date:5/23/2013)... MENLO PARK, Calif. , May 23, 2013 /PRNewswire/ ... an oral treatment for pain has reached an important ... clinical trial of VBY-036 - a selective cathepsin S ... of VBY-036 is a double-blind, randomized, placebo-controlled study designed ... escalating doses of VBY-036 in healthy adults. ...
(Date:5/23/2013)... The New Jersey chapter of the largest ... Associates (BDPA), is hosting its 10th annual Families in ... event will encourage students and their parents to explore ... from many of the industries’ finest teachers. Held from ... Institute of Technology, the event will include workshops, instruction ...
(Date:5/23/2013)... May 23, 2013 SynCardia Systems, Inc. ... only FDA, Health Canada and CE (Europe) approved Total ... in Scotland, which boasts more than 380,000 visitors annually, ... powered by the Freedom® portable driver as part ... most advanced exhibitions of its kind. , “BodyWorks ...
Breaking Biology Technology:StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3Virobay, Inc. initiates a Phase 1 Trial of VBY-036, a compound intended for the treatment of neuropathic pain 2Virobay, Inc. initiates a Phase 1 Trial of VBY-036, a compound intended for the treatment of neuropathic pain 3Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2SynCardia Total Artificial Heart Featured in $3 Million Exhibition at Glasgow Science Centre 2SynCardia Total Artificial Heart Featured in $3 Million Exhibition at Glasgow Science Centre 3
... March 12 Maryland biotech CEOs and companies were honored ... region,s fourth bioscience award competition. , , Winners ... , Best ... CEO, Osiris Therapeutics, Inc. Mills, Columbia-based company has ...
... ERT, a leading provider of centralized ECG and ... medical device, and related industries, announced today that it ... on Booth #1253/1254 at the 21st Annual DIA Euromeeting, ... inviting attendees to three speaking sessions, which will discuss ...
... Arkion(R) Life Sciences has received their first ever Section ... in Louisiana and Missouri effective March 6, 2009, through ... rice growers in these states can protect their seed ... repellent effectively stops birds from eating the newly planted ...
Cached Biology Technology:Three Firms, Two Training Programs Garner Greater Baltimore Committee's 2009 Bioscience Awards 2ERT to Showcase Its Clinical Trials Portfolio at DIA's 21st Euromeeting 2ERT to Showcase Its Clinical Trials Portfolio at DIA's 21st Euromeeting 3AV-1011 Bird Repellent to Protect Rice Seed Approved for Use in Louisiana and Missouri 2