Navigation Links
International team sheds new light on biology underlying schizophrenia
Date:7/21/2014

July 21, 2014 (Toronto) As part of a multinational, collaborative effort, researchers from Canada's Centre for Addiction and Mental Health (CAMH) have helped identify over 100 locations in the human genome associated with the risk of developing schizophrenia, in what is the largest genomic study published on any psychiatric disorder to date. The findings, published online in Nature, point to biological mechanisms and pathways that may underlie schizophrenia, and could lead to new approaches to treating the disorder, which has seen little innovation in drug development in more than 60 years.

The research was led by senior author Michael O'Donovan at Cardiff University School of Medicine, and CAMH was the only Canadian site in the collaboration.

Schizophrenia, a debilitating mental illness that affects approximately one out of every 100 people worldwide, is characterized by hallucinations, delusions, and disordered thinking, and often emerges in the teens and early 20s. Its lifetime impact on individuals and society is high, both in terms of direct health-care and other costs, as well as lost productivity and unemployment, which costs an estimated $6.85 billion a year in Canada.

Medications currently on the market treat only one of the symptoms of the illness (psychosis), and there are no effective treatments for the debilitating cognitive symptoms of schizophrenia. In part, treatment options are limited because the biological mechanisms underlying schizophrenia have not been understood.

Recent research focusing on the genetic underpinnings of schizophrenia has revealed the complexity of the illness. Evidence suggests that it is caused by the combined effects of many genes, and roughly two dozen genomic regions have been found to be associated with schizophrenia. The new study confirms those earlier findings, and expands our understanding of the genetic basis of schizophrenia and its underlying biology.

In
'/>"/>

Contact: Kate Richards
kate.richards@camh.ca
416-535-8501 x36015
Centre for Addiction and Mental Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Riverside entomologist receives international honor for chemical ecology contributions
2. Louisiana Tech University professor presents at International Bioprinting Congress
3. Montreal hosts International Union of Microbiology Societies congresses
4. International Space Station researcher guides aim to maximize science
5. Registration is now open for the HFES 2014 International Annual Meeting
6. Largest International Meeting for the Study of Reproductive Biology Attracts Researchers from 36 Countries in Grand Rapids, Michigan
7. International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019
8. Marshall University to partner with international company in drug development venture
9. The ICIST-KAIST International Conference 2014 from August 4-8, 2014 in Korea
10. International Tree Nut Council study results may help people with type 2 diabetes
11. 10th International Symposium on Earthworm Ecology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... scientists were instrumental in the creation of the Santa ... classify the fire threat potential of the powerful, hot, ... into an inferno. The index was introduced Sept. 17 ... and San Diego Gas and Electric. , The index ... that will be used to help fire agencies and ...
(Date:9/17/2014)... (Sept. 17, 2014) A rare genetic disorder known as ... a recent joint investigation by researchers at San Diego ... In addition to suggesting better treatment options for people ... into the genetic underpinnings of autism., Jacobsen syndrome affects ... Institutes of Health. It occurs in a person when ...
(Date:9/17/2014)... IMIM (Hospital del Mar Medical Research Institute) and at ... a study in eLife showing that RNA ... evolution of new proteins, some of which could have ... proteins from the instructions found in an RNA molecule. ... containing information for the synthesis of proteins, meaning it ...
Breaking Biology News(10 mins):UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2A link between Jacobsen syndrome and autism 2Parts of genome without a known function may play a key role in the birth of new proteins 2
... video games can help to train the brain to become ... Queen Mary University of London and University College London (UCL). ... flexibility, described as a person,s ability to adapt and switch ... time to solve problems. Two groups of volunteers were ...
... drug and dietary supplement manufacturers are updating the tests used ... impurities, and the stringent new requirements, instruments and costs are ... of Chemical & Engineering News . C&EN is the ... scientific society. Ann Thayer, C&EN senior correspondent, explains that ...
... role in how people,s taste receptors send signals, leading ... Penn State food scientists. These varied, genetically influenced responses ... a range of artificial sweeteners to accommodate different consumer ... respond to tastes of foods," said John Hayes, assistant ...
Cached Biology News:Playing video games can boost brain power 2Multiple genes manage how people taste sweeteners 2
(Date:9/17/2014)... Hussey Copper , a leader in ... copper, announces Gilmour Academy Ice Arena,s conversion of more ... solid touch surface to help protect against bacteria.  MD-Cu ... that kills greater than 99.9% of MRSA, E-coli and ... , Innovative Gilmour Academy ...
(Date:9/17/2014)... , 17 de septiembre de 2014 /PRNewswire/ ... principal proveedor mundial de soluciones logísticas avanzadas ... de la vida, anunció hoy la contratación ... global con sede en Rótterdam, Países Bajos, ... clientes Europa en rápido crecimiento. Según los ...
(Date:9/17/2014)... The Pistoia Alliance, a global not ... to innovation in life sciences R&D through pre-competitive ... as Executive Director Business Development North America, as ... , Carmen joins the Pistoia Alliance from Accelrys ... Accelrys, she managed various life sciences and material ...
(Date:9/16/2014)... 2014  Biocom, the association representing the ... 9 th Annual National Health Information Technology Week, ... in improving our health care system. ... the world,s most vibrant hubs for health IT and ... to genomic testing to remote patient monitoring," said ...
Breaking Biology Technology:Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2Biocom Recognizes National Health IT Week 2
... Practical Implementation of ... Intra-Operative Imaging, NUREMBERG, Germany, October 13 ... at the beginning of,the year, Ziehm Imaging, provider of mobile x-ray ... provides,training in line with international standards, in order to keep its,partners ...
... SYDNEY, Australia, Oct. 13 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,Ltd (AXS: ... Quarterly,Report to Shareholders on the afternoon of Wednesday ... teleconference the following morning to,review the quarter and ... on Thursday 16th October at 8.30am (Sydney),(Wednesday 15th ...
... Oct. 10 Cell Therapeutics, Inc.,(CTI) (Nasdaq and ... to,request a hearing with the NASDAQ Listing Qualifications ... NASDAQ Marketplace Rule 4450(b)(1)(A),which requires a minimum market ... a Staff Determination Letter from The NASDAQ Stock ...
Cached Biology Technology:Ziehm Imaging Extends its Training Offer 2Ziehm Imaging Extends its Training Offer 3Ziehm Imaging Extends its Training Offer 4Cell Therapeutics to Request a Hearing With NASDAQ Following Receipt of Staff Determination Letter 2Cell Therapeutics to Request a Hearing With NASDAQ Following Receipt of Staff Determination Letter 3
IMAGEQUANT 100 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
Request Info...
RayBio Human Cytokine Antibody Array 1.1 (4 array membranes) with Accessory, detects 20 cytokines (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
...
Biology Products: