Navigation Links
International team reveals first prognosticator of survival in aggressive cancer
Date:9/3/2008

(Philadelphia, PA September 4, 2008) The tumor suppressor gene pRb2/p130 may provide the first independent prognostic biomarker in cases of soft tissue sarcoma (STS), according to an international collaboration of researchers, including scientists at the Sbarro Institute for Cancer Research and Molecular Medicine at the College of Science and Technology at Temple University in Philadelphia, PA, the Department of Human Pathology and Oncology, University of Siena and the Center of Oncological Research of Mercogliano (CROM) in Avellino, Italy.

The research appears in the latest issue of Clinical Cancer Research (www.aacrjournals.org).

The findings show that a reduction in the expression of pRb2/p130 can mean a higher risk of recurrence and death from STSs. The gene pRb2/p130, a member of the retinoblastoma family of genes, regulates a portion of the cell cycle.

Clinicians have long sought a prognostic test for the disease, which can be highly aggressive and unpredictable, making it difficult to determine the most beneficial course of chemotherapy and/or radiation treatments following surgery.

A prognostic indicator will help doctors determine which patients have a higher risk of recurrence of the disease and who might benefit from a more aggressive adjuvant therapy.

In the study, researchers examined specimens taken from 41 patients with STS. In a subset of 31 cases of nonmetastatic cancers, they found a direct relationship between pRb2/p130 expression and the clinical outcome of patients.

"We found that pRb2/p130 expression was lost or decreased and significantly correlated with recurrence of disease and poor survival rates in the subset of patients with nonmetastatic tumors," said Valeria Masciullo, M.D., Ph.D., lead author of the study.

"A prognostic test could define the natural history of STSs, while also helping to identify possible targets for new kinds of therapies," said Antonio Giordano, M.D., Ph.D., the Director of the Sbarro Institute, Professor of Molecular Biology at the College of Science and Technology at Temple University in Philadelphia, PA and Full Professor of Pathological Anatomy and Histology of the University of Siena.

The researchers noted that the reliability of pRb2/p130 as a potential marker in the clinical routine assessment and management of patients with STS deserves to be further evaluated in long-term follow-up studies on a larger number of cases.


'/>"/>

Contact: Ilene Raymond Rush
irush@shro.org
215-635-5162
Sbarro Health Research Organization
Source:Eurekalert

Related biology news :

1. [video] Michael DePasquale, CEO of BIO-key International, Inc., Discusses Q2 2008 Revenue Growth on WallSt.nets 3-Minute Press Show
2. NYU Langone Medical Centers tip sheet to the International Conference on Alzheimers Disease 2008
3. International conference to release new findings on smell and taste
4. International team identifies 21 new genetic risk factors for Crohns disease
5. 2008 ASABE Annual International Meeting
6. The 12th International Behavioral Ecology Congress held at Cornell University, Aug. 10-14
7. Biotechnology key to developing sustainable industries says international panel
8. BBVA Foundation international study on attitudes to stem cell research
9. International symposium explores fire suppression economics
10. International workshop to address capacity building for rainforest leaders
11. Great Ape Trust to gather internationally recognized scientists for Decade of the Mind III
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
Breaking Biology News(10 mins):
(Date:7/13/2017)... , ... July 13, 2017 , ... ... accreditation in Specialty Pharmacy. URAC is the independent leader in promoting healthcare quality ... a comprehensive commitment to quality care, improved processes and better patient outcomes. ...
(Date:7/13/2017)... ... July 13, 2017 , ... FireflySci Inc. started ... Blast forward seven years and now they are home to a tremendous line ... wavelength accuracy, and resolution testing. , One mega advantage that FireflySci ...
(Date:7/13/2017)... ... July 13, 2017 , ... After 11 years ... Science Center, Christopher Laing, MRCVS, Ph.D. has been tapped to lead the effort ... will become the first Executive Director at the newly formed Capital City Innovation ...
(Date:7/13/2017)... , ... July 13, 2017 , ... Microscan , ... solutions for life sciences, will demonstrate advancements of the MicroHAWK platform for barcode reading ... from Booth #4456 at the AACC Clinical Lab Expo, taking place on August 1–3 ...
Breaking Biology Technology: