Navigation Links
International team reveals first prognosticator of survival in aggressive cancer
Date:9/3/2008

(Philadelphia, PA September 4, 2008) The tumor suppressor gene pRb2/p130 may provide the first independent prognostic biomarker in cases of soft tissue sarcoma (STS), according to an international collaboration of researchers, including scientists at the Sbarro Institute for Cancer Research and Molecular Medicine at the College of Science and Technology at Temple University in Philadelphia, PA, the Department of Human Pathology and Oncology, University of Siena and the Center of Oncological Research of Mercogliano (CROM) in Avellino, Italy.

The research appears in the latest issue of Clinical Cancer Research (www.aacrjournals.org).

The findings show that a reduction in the expression of pRb2/p130 can mean a higher risk of recurrence and death from STSs. The gene pRb2/p130, a member of the retinoblastoma family of genes, regulates a portion of the cell cycle.

Clinicians have long sought a prognostic test for the disease, which can be highly aggressive and unpredictable, making it difficult to determine the most beneficial course of chemotherapy and/or radiation treatments following surgery.

A prognostic indicator will help doctors determine which patients have a higher risk of recurrence of the disease and who might benefit from a more aggressive adjuvant therapy.

In the study, researchers examined specimens taken from 41 patients with STS. In a subset of 31 cases of nonmetastatic cancers, they found a direct relationship between pRb2/p130 expression and the clinical outcome of patients.

"We found that pRb2/p130 expression was lost or decreased and significantly correlated with recurrence of disease and poor survival rates in the subset of patients with nonmetastatic tumors," said Valeria Masciullo, M.D., Ph.D., lead author of the study.

"A prognostic test could define the natural history of STSs, while also helping to identify possible targets f
'/>"/>

Contact: Ilene Raymond Rush
irush@shro.org
215-635-5162
Sbarro Health Research Organization
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. [video] Michael DePasquale, CEO of BIO-key International, Inc., Discusses Q2 2008 Revenue Growth on WallSt.nets 3-Minute Press Show
2. NYU Langone Medical Centers tip sheet to the International Conference on Alzheimers Disease 2008
3. International conference to release new findings on smell and taste
4. International team identifies 21 new genetic risk factors for Crohns disease
5. 2008 ASABE Annual International Meeting
6. The 12th International Behavioral Ecology Congress held at Cornell University, Aug. 10-14
7. Biotechnology key to developing sustainable industries says international panel
8. BBVA Foundation international study on attitudes to stem cell research
9. International symposium explores fire suppression economics
10. International workshop to address capacity building for rainforest leaders
11. Great Ape Trust to gather internationally recognized scientists for Decade of the Mind III
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... noise of the South, but the night belongs to the ... heavy from the humidity and the sounds of wildlife. ... frogs, toads and salamanders, is the center of amphibian biodiversity ... the auditorium for their symphonic choruses, the scientists of the ... have front-row seats. , Amphibians, which rely on ...
(Date:5/17/2013)... Why Tibetan antelope can live at elevations of ... research published in Nature Communications , investigators ... evidence that some genetic factors may be associated ... The data in this work will also provide ... biology of other ruminant species. , The Tibetan ...
(Date:5/17/2013)... LEMONT, Ill. An international team ... internal structure and cell movement inside a living frog ... showcases a new method to advance biological research and ... at Northwestern University and the Karlsruher Institut fr Technologie ... at the U.S. Department of Energy,s Argonne National Laboratory, ...
Breaking Biology News(10 mins):Front-row seats to climate change 2Front-row seats to climate change 3Front-row seats to climate change 4The genome sequence of Tibetan antelope sheds new light on high-altitude adaptation 2New X-ray method shows how frog embryos could help thwart disease 2
... following highlights summarize research papers that have been recently ... Journal of Geophysical ,Research-Solid Earth (JGR-B), and ... , 1. Active faults newly identified in Pacific Northwest ... Seattle and south of Vancouver, ,British Columbia, around the ...
... of us contribute to the greenhouse gas emissions that are causing ... emissions. How we travel, what we eat, what we consume ... contribute to our carbon footprint . How, though, do ... an opportunity to find out on April 26, when Louis ...
... in the United States are obese, and in inner-city neighborhoods, ... and physical inactivity are the main culprits, there is new ... A study by Columbia University,s Mailman School of Public Health ... higher concentrations of chemicals called polycyclic aromatic hydrocarbons, or PAH, ...
Cached Biology News:AGU journal highlights for April 16, 2012 2AGU journal highlights for April 16, 2012 3AGU journal highlights for April 16, 2012 4AGU journal highlights for April 16, 2012 5AGU journal highlights for April 16, 2012 6AGU journal highlights for April 16, 2012 7AGU journal highlights for April 16, 2012 8Measuring our carbon footprint 2Prenatal exposure to air pollution linked to childhood obesity 2Prenatal exposure to air pollution linked to childhood obesity 3
(Date:5/17/2013)... , May 17, 2013 /PRNewswire-iReach/ -- Aridis is ... reached with Switzerland -based Kenta ... human monoclonal antibody (mAb) products, and technologies. This ... products for treatment of infections by common pathogens ... aureus , Pseudomonas aeruginosa , Acinetobacter ...
(Date:5/17/2013)... 17, 2013 Rust removal is one of ... home items could be damaged. To help rust contractors make ... its no-scrubbing rust remover it called Rusterizer. It ... with 10% discount. , My Cleaning Products explained that rust ... or by staining them. The first one, it said, ...
(Date:5/16/2013)... May 16, 2013 Oven Industries, Inc. ... controllers and temperature sensors since 1964. Expertly ... in industrial control system applications. As one ... includes a generic, control loop feedback system, which helps ... used to adjust a systematic process, using a control ...
(Date:5/16/2013)... 16, 2013  HealthSparq, a trusted provider of ... largest regional health plans, will debut a new ... (AHIP) Institute 2013 conference on June 13.  The ... how health insurance companies across the country are ... marketplace demands for increased healthcare transparency. ...
Breaking Biology Technology:Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 2Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 3Organic-Based Rust Remover Cuts Down Price by 10%, My Cleaning Products Details Mechanics How to Get the Discount 2New PID Temperature Controllers Announced by Oven Industries Inc. 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 3
... National Laboratory,have discovered a way to increase the ... a portable biosensor that can address a major,concern ... the need to quickly distinguish between individuals who ... sensor components resemble a pregnancy test strip and ...
... Lexington, Kentucky, Darrell Taulbee can be found mixing up a ... grow a better Big Boy or distill a smoother bourbon, ... the Homeland Securitys Science & Technology Directorate (S&T), Taulbee sets ... Taulbee putters with this stuff to make sure another Oklahoma ...
... Good news for public health: Bioengineering researchers from the ... nanoparticle that can deliver vaccines more effectively, with fewer ... of current vaccine technologies. , Described in an ... Biotechnology, the vaccine delivery platform is a deceptively simple ...
Cached Biology Technology:Truly sick or simply scared? 2Brewing a blast-less fertilizer 2New nanoparticle vaccine is more effective but less expensive 2New nanoparticle vaccine is more effective but less expensive 3
...
[14C]Polyethylene glycol 4000, 9.25 MBq, 250 uCi. Aqueous solution containing 3% ethanol, sterilized. 370-740 MBq/g, 10-20 mCi/g.1.85 MBq/ml, 50 uCi/ml. Category: Radiochemicals &Radiation Safety, ...
Use the DUALmembrane kit 3 to carry out DUALmembrane interaction analysis and cDNA library screening to characterize interactions between integral membrane proteins and to identify novel interaction ...
Human Serum FDA Licensed US Donor Centers Sterile / Non-sterile: Sterile Filtered to 0.2 micron Information: Extensive Viral Testing ...
Biology Products: