Navigation Links
International team identifies 21 new genetic risk factors for Crohn's disease
Date:6/29/2008

An international consortium of Crohn's disease researchers has combined data from three independent studies to identify 21 new genetic variants associated with the inflammatory bowel disorder, bringing the total number of risk factors to 32. Several of these are involved with the immune system's inital response to pathogens, supporting earlier evidence that disruptions in a process called autophagy may lead to the disorder's characteristic immune system overactivity. The report will appear in the journal Nature Genetics and is receiving early online release.

"This greatly increases our knowledge of the genetic architecture of Crohn's and gives us more detailed insight into the biological underpinnings of the disease," says Mark Daly, PhD, of the Massachusetts General Hospital (MGH) Center for Human Genetic Research and the Broad Institute of MIT and Harvard, the report's senior author. "Better understanding of the precise functions of these genes and the molecular effects of Crohn's-associated variants should lead us to novel strategies for therapies and, someday, prevention."

In 2007 three separate research teams a North American-based team, involving Daly and colleagues at six other institutions and clinical sites; a U.K. team supported by the Wellcome Trust; and a group of French and Belgian investigators each published genome-wide association studies (GWAS) of Crohn's disease that, combined with earlier studies, brought the total number of Crohn's-associated gene sites to 11. Those explained only a small proportion of the heritability of Crohn's, which affects nearly half a million people in the U.S.

Since the power of any GWAS is limited by the number of samples available for screening, the three teams combined their data through a process called meta-analysis, allowing the comparison of data from more than 3,200 Crohn's patients with more than 4,800 controls. That was supplemented by an analysis of new data from
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. 2008 ASABE Annual International Meeting
2. The 12th International Behavioral Ecology Congress held at Cornell University, Aug. 10-14
3. Biotechnology key to developing sustainable industries says international panel
4. BBVA Foundation international study on attitudes to stem cell research
5. International symposium explores fire suppression economics
6. International workshop to address capacity building for rainforest leaders
7. Great Ape Trust to gather internationally recognized scientists for Decade of the Mind III
8. Major international collaboration offers new clues to genetics of type 2 diabetes
9. DHS Begins Collecting 10 Fingerprints From International Visitors at New Yorks John F. Kennedy International Airport
10. Presidents science adviser to address IEEE International Homeland Security Conference
11. International team announces discovery of massive Jurassic marine reptile
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... the international Cancer Genomics of the Kidney consortium ... kidney cancer and exposure to aristolochic acid, an ... in Nature Communications , have important implications ... than 140,000 people every year, and in Central ... part of the International Cancer Genome Consortium (ICGC), ...
(Date:10/28/2014)... of the tragic realities of cancer is that ... toxic and their effectiveness varies unpredictably from patient ... poised to change this reality by rapidly assessing ... an individual,s cancer before chemotherapy begins. , A ... by Assistant Professor Melissa Skala has developed the ...
(Date:10/28/2014)... Scientists from North America, Europe and China have published ... Academy of Sciences that reveals important details about ... our planet., From strange and exotic algae, mosses, ferns, ... the grains and vegetables we eat and the ornamental ... shares over a billion years of history., "Our study ...
Breaking Biology News(10 mins):Kidney cancer in Central Europe 2Improving breast cancer chemo by testing patient's tumors in a dish 2Improving breast cancer chemo by testing patient's tumors in a dish 3New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3
... shows that birds may choose their mate with the help ... their young a more efficient immune system. This has been ... in Sweden, in a Swedish-French collaboration. Humans and many ... mate with the right smell can give the offspring an ...
... why autism spectrum disorders are almost five times more common ... to a five-year, $15 million National Institutes of Health (NIH) ... Centers of Excellence (ACE) research program. Led by ... Yale ACE award is part of a $100 million National ...
... - Influenza outbreaks in the United States typically begin ... spread in seasonal waves across geographic zones. But the ... to the next has baffled scientists. In a ... Obscure Consequence," Elena Naumova, Ph.D., professor of civil and ...
Cached Biology News:Influenza research: Can dynamic mapping reveal clues about seasonality? 2
(Date:10/27/2014)... 2014 Ryan Carfley , Managing Partner ... sit down with Bryan Hamilton, the publisher of the Triangle ... talent in the Research Triangle region of North Carolina. , ... at the roundtable include the role of social media ... work/life balance and the unique role that Millennials play in ...
(Date:10/27/2014)... Oct. 27, 2014 Kalorama Information says that ... concern in the United States ... healthcare market researcher said the FDA,s Emergency Use Authorization (EUA) ... tests for the detection of the Ebola virus was ... Kalorama routinely assess the IVD industry and its biennial ...
(Date:10/27/2014)... The report “Smart Highway Market by Technology ... and by Display (Variable Message Signs, Digital Signage) ... market into various sub-segments with in-depth analysis and ... and restraints for this market with insights into ... tables and 37 figures spread through 141 pages ...
(Date:10/26/2014)... October 26, 2014 The report ... ADC, Network Security Equipment, WAN Optimization Appliances]: Global ... segments the data center networking market into various ... revenues. The report also identifies the factors driving ... impacting it along with the future roadmaps. , ...
Breaking Biology Technology:Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4
... Aaron Mitchell, managing principal at global management consulting firm ... of 2011 by Consulting Magazine. Mitchell was recognized for directing ... several years and during a major, recent product launch. ... top consultants," said Mitchell, who has more than 10 years ...
... 1, 2011 Reportlinker.com announces that a ... its catalogue: Biochips and ... http://www.reportlinker.com/p0350354/Biochips-and-Microarrays---Technologiesmarkets-and-companies.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics This ... based on technologies and applications. The report ...
... Reportlinker.com announces that a new market ... Osteosarcoma Therapeutics - Pipeline ... http://www.reportlinker.com/p0546797/Osteosarcoma-Therapeutics---Pipeline-Assessment-and-Market-Forecasts-to-2017.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology ... Forecasts to 2017 Summary ...
Cached Biology Technology:Managing Principal at ZS Associates Named One of Consulting Magazine's Top 25 Consultants of 2011 2Reportlinker Adds Biochips and Microarrays - Technologies, markets and companies 2Reportlinker Adds Biochips and Microarrays - Technologies, markets and companies 3Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 4Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 5Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 6Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 7Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 8Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 9Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 10
ERalpha (Ser 104/106)...
... Phosphatase, Calf Intestinal (CIAP), catalyzes the hydrolysis ... ribo- and deoxyribonucleoside triphosphates. This enzyme is ... linearized cloning vector DNA by removing phosphate ... be used for the dephosphorylation of 5 ...
Mouse CXCR3 Allophycocyanin MAb (Clone 220803)...
Homo sapiens palladin...
Biology Products: