Navigation Links
International team completes systematic, genomic study of cervical cancer
Date:12/25/2013

s the samples to be considered significant in cervical cancer. Eight of these mutations had not been linked to the disease previously, and two had not previously been seen in any cancer type.

Among the most notable findings were somatic point mutations in the gene ERBB2, which was found in a small but significant subset of the tumors. Mutations in this gene, which is also known as Her-2, had not been previously been linked to cervical cancer, but it is a known oncogene common in breast cancer. Treatments exist that target the gene.

"This suggests that a subset of cervical cancer patients could be candidates for clinical trials involving ERBB2 inhibitors, which are available and FDA-approved," explained Akinyemi Ojesina, a postdoctoral fellow in Matthew Meyerson's lab at the Broad Institute and Dana-Farber. Ojesina served as a co-first author of the paper along with Lee Lichtenstein of the Broad's Cancer Genome Analysis Group. "It is an exciting finding that could be translatable to the clinic."

The team also identified a novel mutation in the gene MAPK1. MAPK1 is one of the final steps in the MAP kinase signaling pathway a network of interconnected genes that play a role in cell growth regulation. Mutations in other genes in the pathway have been known to drive cancer, but this is the first time that MAPK1 itself has been found to be mutated. The finding opens up the possibility that MAPK1, like other genes in the MAP kinase signaling pathway, may be a viable therapeutic target.

Another key finding was the prevalence of mutations in genes affecting the immune system. Mutations in the gene HLA-A, which helps the body distinguish its own proteins from foreign invaders, were previously found to drive squamous cell lung cancer. In this study, another gene in the same complex HLA-B was found to be commonly mutated in cervical squamous cell carcinoma. This suggests that disruptions to the immune system may play a bigger role in can
'/>"/>

Contact: Nicole Davis
ndavis@broadinstitute.org
617-714-7152
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. World e-waste map reveals national volumes, international flows
2. First International Bioenergy Conference brings together world-leading experts
3. International gene therapy trial for bubble boy disease shows promising early results
4. 20th International AIDS Conference (AIDS 2014) plenary speakers announced
5. Antibiotic resistance is a international issue that better education can address
6. NSF, with interagency and international partners, makes first round of grants to understand Arctic sustainability
7. Population Council to present more than 40 studies at International Conference on Family Planning
8. International collaboration finds 11 new Alzheimers genes to target for drug discovery
9. PETA and its international affiliates launch not-for-profit international science company
10. Stepping up the Pace: 20th International AIDS Conference (AIDS 2014) theme selected
11. International Niels Bohr Conference: An open world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... everyday household items such as washing machines could hold ... new study has claimed., As part of an EPSRC ... including those from the University of Exeter, have shown ... replicated in the natural world to help restock declining ... in essence a built-in feedback control mechanism to maintain ...
(Date:7/10/2014)... Consuming a whole fresh avocado with either an ... A carotenoid (alpha- and beta-carotene) absorption and conversion of ... according to new research (1) published in ... Vitamin A is involved in reproductive health and growth ... and has antioxidant properties. Provitamin A carotenoids, like alpha- ...
(Date:7/10/2014)... 2014Women in the West African nation Burkina Faso ... option. Sayana Press has the potential to increase ... health system and in communities by combining a ... (depot medroxyprogesterone acetate)with the BD Uniject injection system. ... African countries expected to begin introducing Sayana Press ...
Breaking Biology News(10 mins):Feedback control could be key to robust conservation management 2New research: Fresh avocado enhances absorption of essential nutrients for healthy living 2Injectable contraceptive launched in Burkina Faso to expand choice and address unmet need 2Injectable contraceptive launched in Burkina Faso to expand choice and address unmet need 3
... Researchers at the University of Granada (UGR) have studied the ... known population of Polygala balansae in Europe, a ... which was previously thought to be exclusive to Morocco. The ... and included on the list of threatened species. In ...
... taking non-oral and oral hormonal contraceptives were at highest ... study of female German medical students published today in ... women taking non-hormonal contraceptives were at lowest risk for ... "Sexual problems can have a negative impact on both ...
... change is happening today, a Kansas State University professor ... forest and grassland ecosystems. Kendra McLauchlan, assistant professor ... Foundation CAREER Award to examine contrasts in vegetation history ... nitrogen cycling and other ecosystem properties. McLauchlan is the ...
Cached Biology News:Polygala balansae, a new bush to Europe, at risk of extinction in Spain 2Hormonal contraceptives associated with higher risk of female sexual dysfunction 2Hormonal contraceptives associated with higher risk of female sexual dysfunction 3K-State professor using NSF award to study the impact of nitrogen deposition on global change 2
(Date:1/15/2014)... device," Nobel laureate Herbert Kroemer famously observed, referring ... the junctures where layers of different materials meet. ... between layers of metal oxides are becoming increasingly ... spintronics, high-temperature superconductors, ferroelectrics and multiferroics. Realizing the ...
(Date:1/15/2014)... 15, 2014 Look inside the new ... for the lab, from fluid handling to instruments to ... ship when you order. , Preferred Solutions features ... from the L/S® model for precise flow control and ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 This webinar ... nonclinical and clinical safety assessment in biosimilars. , Regulatory ... for biosimilar drug development, however the complex nature of ... quality, safety and efficacy extremely challenging. Based on the ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent viruses ... is the Epstein Barr Virus (EBV), and one of these ... chronic inflammatory disease that destroys the body’s joints. As predicted ... high concentrations of EBV DNA in their bodies (1). ...
Breaking Biology Technology:A deeper look at interfaces 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... , , , , , ... for examining , regulatory promoter and enhancer sequences ... cases, the element under investigation (promoter, enhancer) is cloned , ... subsequently , used to transfect cells. Quantification of ...
... , , , , , ... , , , , ... is an essential step in some of the most innovative , ... the cloning of mammals, and vaccination against cancer. Compared to the , ...
... , , , Note: Genomic DNA is fragile. ... Use suitable large-bore pipet tips or equipment when , pipetting genomic ... Place a 1 cm tail sample into a ... be stored at 20C. To minimize possible cross-contamination, , ...
Cached Biology Technology:Genetic Reporter Systems 2Genetic Reporter Systems 3Genetic Reporter Systems 4Principles and applications of electrical cell fusion 2Principles and applications of electrical cell fusion 3Principles and applications of electrical cell fusion 4Principles and applications of electrical cell fusion 5Mouse Tail Genomic DNA Isolation Protocol(1) 2