Navigation Links
International team completes systematic, genomic study of cervical cancer
Date:12/25/2013

s the samples to be considered significant in cervical cancer. Eight of these mutations had not been linked to the disease previously, and two had not previously been seen in any cancer type.

Among the most notable findings were somatic point mutations in the gene ERBB2, which was found in a small but significant subset of the tumors. Mutations in this gene, which is also known as Her-2, had not been previously been linked to cervical cancer, but it is a known oncogene common in breast cancer. Treatments exist that target the gene.

"This suggests that a subset of cervical cancer patients could be candidates for clinical trials involving ERBB2 inhibitors, which are available and FDA-approved," explained Akinyemi Ojesina, a postdoctoral fellow in Matthew Meyerson's lab at the Broad Institute and Dana-Farber. Ojesina served as a co-first author of the paper along with Lee Lichtenstein of the Broad's Cancer Genome Analysis Group. "It is an exciting finding that could be translatable to the clinic."

The team also identified a novel mutation in the gene MAPK1. MAPK1 is one of the final steps in the MAP kinase signaling pathway a network of interconnected genes that play a role in cell growth regulation. Mutations in other genes in the pathway have been known to drive cancer, but this is the first time that MAPK1 itself has been found to be mutated. The finding opens up the possibility that MAPK1, like other genes in the MAP kinase signaling pathway, may be a viable therapeutic target.

Another key finding was the prevalence of mutations in genes affecting the immune system. Mutations in the gene HLA-A, which helps the body distinguish its own proteins from foreign invaders, were previously found to drive squamous cell lung cancer. In this study, another gene in the same complex HLA-B was found to be commonly mutated in cervical squamous cell carcinoma. This suggests that disruptions to the immune system may play a bigger role in can
'/>"/>

Contact: Nicole Davis
ndavis@broadinstitute.org
617-714-7152
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. World e-waste map reveals national volumes, international flows
2. First International Bioenergy Conference brings together world-leading experts
3. International gene therapy trial for bubble boy disease shows promising early results
4. 20th International AIDS Conference (AIDS 2014) plenary speakers announced
5. Antibiotic resistance is a international issue that better education can address
6. NSF, with interagency and international partners, makes first round of grants to understand Arctic sustainability
7. Population Council to present more than 40 studies at International Conference on Family Planning
8. International collaboration finds 11 new Alzheimers genes to target for drug discovery
9. PETA and its international affiliates launch not-for-profit international science company
10. Stepping up the Pace: 20th International AIDS Conference (AIDS 2014) theme selected
11. International Niels Bohr Conference: An open world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... 2015 Synaptics, Inc. (Nasdaq: SYNA ), ... that members of the executive management team will present ... Technology Leadership Forum on Tuesday, August 11, 2015 at ... at the Sonnenalp Resort in Vail, CO. ... forward-looking information. An audio webcast of the event will ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julho de 2015 ... Genômica (ICG-10, www.icg-10.org ) será realizada pela BGI de ... China . A conferência está ... inauguração em 2006, a ICG se tornou uma das ... e um dos encontros científicos mais dinâmicos, entusiastas e ...
(Date:7/31/2015)... Die 10. internationale Konferenz zu Genomik (ICG-10, ... vom 22. bis 25. Oktober 2015 in ... Die Konferenz feiert in diesem Jahr ihr ... ICG weltweit zu einem der einflussreichsten jährlichen Treffen ... dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen Zusammentreffen. ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
... will publish research that demonstrates how a biosensor can detect ... step in identifying and fighting superbugs, a major public health ... the United States in recent years. The technology is ... University and the Keesler Air Force Base with funding from ...
... Scientists have discovered that fat cells in the knee ... the way for new gene therapies that could offer relief ... in the knee joints secretes a protein called pro-factor D ... that is linked to arthritis," said Nirmal Banda, Ph.D., associate ...
... May 7, 2013 From New York City,s Central Park ... store an estimated 708 million tons of carbon, an environmental ... a recent U.S. Forest Service study. Annual net ... tons and $1.5 billion in economic benefit. In the ...
Cached Biology News:Biosensor that detects antibiotic resistance brings us one step closer to fighting superbugs 2Discovery shows fat triggers rheumatoid arthritis 2US urban trees store carbon, provide billions in economic value 2US urban trees store carbon, provide billions in economic value 3US urban trees store carbon, provide billions in economic value 4US urban trees store carbon, provide billions in economic value 5US urban trees store carbon, provide billions in economic value 6
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... Since the initial launch of FireflySci Inc. ... quirky humor and excellent customer service. Images such as the Fonz in a lab ... add some flavor to the humdrum spectroscopy field. , FireflySci is proud to ...
(Date:8/27/2015)... , Aug. 27, 2015 The National ... patient,s eyes—and life—were saved by doctors at Vanderbilt University ... with NNFF, NovaBay Pharmaceuticals and Dr. John Crew ... at Seton Medical Center in Daly ... used a breakthrough approach, pioneered by Dr. Crew, that ...
(Date:8/27/2015)... ... ... Inc. Magazine released its annual list of the 5,000 fastest-growing privately held ... the three years through 2014. Being named to the Inc. 5000 list designates a ... , “We are thrilled to make the Inc. 5000 list for 2015,” stated ...
(Date:8/26/2015)... 2015 /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... for the quarter ended June 30, 2015. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... to our Oral Amp B program, rapidly advancing ... Andrew Rae , President & CEO of ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3
... CALGARY, May 1 /PRNewswire-FirstCall/ - Resverlogix Corp.,("Resverlogix") (TSX:RVX) ... a live,teleconference on May 8, 2008 at 9:00 ... the science and the business aspects of the ... question and answer session., The webcast can ...
... May 1 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ... and,medical device company, today announced that it has ... Administration (FDA) to begin,marketing sizes 3-0 and 4-0 ... line. The Quill SRS PDO is a longer-lasting,absorbable ...
... (Nasdaq: RNVS ) announced today that its stockholders ... (Frankfurt Stock Exchange:,EVT) at a special meeting of stockholders ... 5, 2008., In the transaction, each issued and ... into the right to receive 0.5271 of,an American Depositary ...
Cached Biology Technology:Resverlogix Notice of Conference Call & Webcast 2Angiotech Expands Quill(TM) SRS product offering receiving FDA 510(k) approval for smaller size diameters of Quill(TM) SRS PDO 2Angiotech Expands Quill(TM) SRS product offering receiving FDA 510(k) approval for smaller size diameters of Quill(TM) SRS PDO 3Angiotech Expands Quill(TM) SRS product offering receiving FDA 510(k) approval for smaller size diameters of Quill(TM) SRS PDO 4Renovis Stockholders Approve Acquisition by Evotec 2
Normal serum collected from healthy Kunming mice....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
... Services include: ,ISH Protocol Development ... Analyses ,RNA and DNA Screenings ... and Tissues ,Double Labeling of ... and Tissues ,RNA and DNA ...
Request Info...
Biology Products: