Navigation Links
International team completes systematic, genomic study of cervical cancer
Date:12/25/2013

Researchers from the Boston area, Mexico, and Norway have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including at least one for which targeted treatments have been approved for other forms of cancer. The findings also shed light on the role human papillomavirus (HPV) plays in the development of cervical cancer.

The study, which appears online in Nature, addresses a public health concern of global significance: cervical cancer is the second most common cancer in women and is responsible for approximately 10 percent of cancer deaths in women particularly in developing countries where screening methods are not readily accessible. Almost all cases of the disease are caused by exposure to HPV and it is expected that vaccination efforts targeting HPV will decrease cervical cancer cases over time. In the meantime, however, the disease remains a significant threat to women's health.

"Cancer is a disease that affects the whole world, and one question that always arises is: is a given cancer type similar or different across populations?" explained Matthew Meyerson, one of the paper's co-senior authors. Meyerson is a professor of pathology and medical oncology at Dana-Farber Cancer Institute and a senior associate member of the Broad Institute. "While we don't have the complete answer yet in this case, what we are seeing is that, in two different populations, the causes of cervical cancer are similar and, fundamentally in both cases, it comes down to HPV-genome interaction."

To investigate the genomic underpinnings of the disease, the team performed whole exome sequencing, which examines the genetic code in the protein-coding regions of the genome, on samples from 115 cervical cancer patients from Norway and Mexico. In some cases, the researchers also conducted whole genome sequencing (analyzing the g
'/>"/>

Contact: Nicole Davis
ndavis@broadinstitute.org
617-714-7152
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. World e-waste map reveals national volumes, international flows
2. First International Bioenergy Conference brings together world-leading experts
3. International gene therapy trial for bubble boy disease shows promising early results
4. 20th International AIDS Conference (AIDS 2014) plenary speakers announced
5. Antibiotic resistance is a international issue that better education can address
6. NSF, with interagency and international partners, makes first round of grants to understand Arctic sustainability
7. Population Council to present more than 40 studies at International Conference on Family Planning
8. International collaboration finds 11 new Alzheimers genes to target for drug discovery
9. PETA and its international affiliates launch not-for-profit international science company
10. Stepping up the Pace: 20th International AIDS Conference (AIDS 2014) theme selected
11. International Niels Bohr Conference: An open world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... , May 11, 2015  Synaptics Incorporated (NASDAQ: ... interface solutions, today announced the appointment of ... Chief Financial Officer, reporting to Rick Bergman ... current Chief Financial Officer, Kathleen Bayless , ... Mr. Ali brings extensive financial management ...
(Date:5/10/2015)... Fingerprint Cards (FPC) has received an order for ... World Peace Industrial Group (WPI), part of WPG Holdings. WPI ... . Deliveries are planned to take place during Q3 2015 ... China . The order value of 235 ... 1 000 MSEK for 2015.   Jörgen Lantto, acting ...
(Date:5/6/2015)... 2015 LifeBEAM, a developer of bio-sensing technology, ... today that they will expand their partnership in bio-sensing ... cycling helmet and the first joint project between the ... in order to give cyclists more style choices and ... and Lazer announced their plan to release a new ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3
... 2007 Geron Corporation (Nasdaq: GERN) today reported ... embryonic stem cell (hESC)-derived cardiomyocytes improve heart function ... online Aug. 26 in Nature Biotechnology, the landmark ... clinical utility of regenerating damaged heart muscle by ...
... When human heart muscle cells derived from embryonic stem ... attack, they can help rebuild the animal,s heart muscle ... the September issue of Nature Biotechnology. The researchers also ... cells are turned into heart muscle cells and then ...
... in the natural world but so too are cheats ... good but simply reap the benefits of others cooperative ... how cooperation persists despite the threat of cheat takeover ... of Edinburgh and Oxford have found that in bacteria, ...
Cached Biology News:Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction 2Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction 3Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction 4Human derived stem cells can repair rat hearts damaged by heart attack 2Human derived stem cells can repair rat hearts damaged by heart attack 3Social parasites of the smaller kind 2
(Date:5/21/2015)... , May 21, 2015  Prima Biomed Ltd. (NASDAQ: ... is striving to become a leader in the development ... announced that the final CVac data from the Phase ... clear trend for a clinically meaningful improvement in Overall ... remission patients. In the group of second ...
(Date:5/21/2015)... 2015 Patent Offering, The patent’s technology ... or therapeutic imaging within a body lumen (open space). ... having a low cost, single-use disposable illumination and camera ... October 18, 2013 and the patent approval was received ... physician to customize the lighting and magnification of the ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Veolia’s ... an exclusive North American distribution agreement with VWR ... system. , With more than 160 years of ... and services for laboratory and production facilities, has ... excellence and differentiated services to enable science. ...
(Date:5/20/2015)... 19, 2015 Research and Markets ( ... "Global Cell Therapy Market Outlook 2020 " report ... in tissue and regenerative medicine is expected to have ... which could help in the growth of deregulated organs. ... they are unable to form new tissue or sometimes ...
Breaking Biology Technology:Correction Continues after Big Move - BrokerBank Securities, Inc. 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3
... CXM ) and its operating unit InnerCool ... was featured on Science,Channel,s "Cool Stuff: How It ... and is scheduled to be rebroadcast at 8:30 ... Please visit, http://science.discovery.com/tv-schedules/series.html for broadcast dates,and times ...
... Squibb,Company (NYSE: BMY ) announced today that it ... $600 million in aggregate principal amount of,5.450% notes due ... amount,of 6.125% notes due May 1, 2038 in an ... J.P. Morgan Securities Inc., and Morgan,Stanley are acting as ...
... Replidyne, Inc.,(Nasdaq: RDYN ) announced today that it will ... P.M. ET to report first quarter 2008,earnings. On Thursday, May ... shareholder meeting at Company headquarters at 1450 Infinite Drive,in Louisville, ... as follows:, Kenneth J. Collins, President and ...
Cached Biology Technology:Cardium Reports on Science Channel Series Featuring InnerCool's Endovascular Cooling During Brain Surgery at Stanford University 2Cardium Reports on Science Channel Series Featuring InnerCool's Endovascular Cooling During Brain Surgery at Stanford University 3Cardium Reports on Science Channel Series Featuring InnerCool's Endovascular Cooling During Brain Surgery at Stanford University 4Cardium Reports on Science Channel Series Featuring InnerCool's Endovascular Cooling During Brain Surgery at Stanford University 5Cardium Reports on Science Channel Series Featuring InnerCool's Endovascular Cooling During Brain Surgery at Stanford University 6Bristol-Myers Squibb Issues $1.6 Billion of Senior Notes 2Replidyne to Report First Quarter 2008 Earnings 2Replidyne to Report First Quarter 2008 Earnings 3
... The new Class II safety cabinets Heraeus HERAsafe ... and user-orientated design. ,The new frameless slanted ... work area. The new front window design makes ... The large work aperture with a height of ...
... a custom synthesis service for synthetic ... molecules are: Composed of 18-20 ... overhang at the 3-terminus PAGE ... and ready-to-use. Simply order your ...
Mouse monoclonal [AZ24] to Polo like kinase ( Abpromise for all tested applications)....
... System brings together two mature, well-understood ... capture surfaces. This combination produces a ... the detection of molecular binding events ... , Protein-specific capture molecules are immobilized ...
Biology Products: