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International study suggests human genes influence gut microbial composition
Date:1/7/2013

d play a role in influencing the overall makeup of an individual's microbiota, pushing it towards Prevotella dominance instead of an alternative community dominated by a closely related bacteria, Bacteroides. Medical researchers are already considering therapeutic strategies to treat diseases by restoring 'normal' intestinal flora in patients by using pharmacological or dietary changes to create specific modifications in the gut microbiota. Future research, expanding on the current study, could help to more effectively target these treatments.

Associate Professor D'Amato said: "Primarily a proof-of-concept investigation, our pilot study reinforces the idea that large-scale analyses should be undertaken to unravel how variation in the entire human genome relates to variation in the human microbiota."

Dr Quince added: "This is a small study but it could have important implications. We've provided further evidence that the human microbiome may also depend on the human genome, which invites serious investigation in the future."


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