Navigation Links
International study suggests human genes influence gut microbial composition
Date:1/7/2013

New research led by the Karolinska Institutet, Sweden and the University of Glasgow, Scotland, has identified a link between a human gene and the composition of human gastrointestinal bacteria. In a study published as a letter to the journal Gut, the team outline new evidence suggesting that the human genome may play a role in determining the makeup of the billions of microbes in the human gastrointestinal tract collectively known as the gut microbiota.

Mauro D'Amato, Associate Professor at the Department of Biosciences and Nutrition at Karolinska Institutet, said: "The hypothesis that our genes contribute to tailor-make our microbiota is very attractive. We still do not know whether certain DNA variations can result in the assembling and perpetuation of specific microbiota profiles, and this may bear important implications for the potential to treat common diseases through therapeutic modification of the gut flora."

The microbiota, which evolved over tens of thousands of years alongside their human hosts, constitutes a complex and diverse community whose exact composition varies from person to person. It has numerous beneficial physiological and nutritional effects for humans; however, alterations in its bacterial composition have been linked to health problems including obesity and Crohn's disease.

Dr Christopher Quince, of the University of Glasgow's School of Engineering, said: "We ran a statistical analysis on bacterial DNA sequenced from samples of intestinal tissue from 51 healthy people with no history of bowel conditions in relation to 30 specific genes. These genes have been shown to increase the risk of Crohn's disease, and are likely to play an important role in gut-bacteria interactions. We found that DNA variation in one of these genes, known as IRGM, was associated with the presence of increased levels of a type of microbe known as Prevotella."

The research thus suggests that the IRGM gene could play a role in influencing the overall makeup of an individual's microbiota, pushing it towards Prevotella dominance instead of an alternative community dominated by a closely related bacteria, Bacteroides. Medical researchers are already considering therapeutic strategies to treat diseases by restoring 'normal' intestinal flora in patients by using pharmacological or dietary changes to create specific modifications in the gut microbiota. Future research, expanding on the current study, could help to more effectively target these treatments.

Associate Professor D'Amato said: "Primarily a proof-of-concept investigation, our pilot study reinforces the idea that large-scale analyses should be undertaken to unravel how variation in the entire human genome relates to variation in the human microbiota."

Dr Quince added: "This is a small study but it could have important implications. We've provided further evidence that the human microbiome may also depend on the human genome, which invites serious investigation in the future."


'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Related biology news :

1. U of M to lead international virtual institute studying climatic and human effects on Earth
2. International Drug & Explosives Detection Company IDenta Corp. Article to be Published by Zillion International
3. Hogging the spotlight: South Farms pig gets international attention
4. University of Chicagos Graeme Bell receives international diabetes prize
5. An international competition reaffirms the potential of bioinformatics in the diagnosis of disease
6. Major international push to maximize bioscience research to help worlds poorest farmers
7. International team discovers likely basis of birth defect causing premature skull closure in infants
8. UH Case Medical Center leads international study
9. Novetta Solutions Acquires International Biometric Group, LLC
10. International Life Sciences Conferences Address Advancements in High-Content Analysis, Sample Preparation, Clinical Trial Supply and Protein and Antibody Engineering
11. Maya Angelou Center Brings International Women’s Health Summit to Winston-Salem, NC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology ... drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription ... is able to cross the cell membrane and bind intracellular STAT3 and inhibit ...
(Date:10/10/2017)... International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, ... security market and how smart safety and security products impact the competitive ... Parks Associates: Smart Home Devices: Main ... "The residential security market has experienced continued ...
(Date:10/9/2017)... Jupiter, FL (PRWEB) , ... October 09, 2017 , ... ... episode, scheduled to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on ... Agriculture industry is faced with the challenge of how to continue to feed a ...
(Date:10/7/2017)... ... October 06, 2017 , ... Phase ... metagenome deconvolution product, featuring the first commercially available Hi-C kit. Researchers can ... Hi-C metagenome deconvolution using their own facilities, supplementing the company’s full-service ProxiMeta ...
Breaking Biology Technology: