Navigation Links
International study identifies new gene targets for hypertension treatment
Date:9/11/2011

rent findings strongly support its relevance in human patients.

"We have previously shown that variants in natriuretic peptide genes, part of the cGMP system, influence blood pressure. We were therefore pleased but not surprised to see other genes that influence the cGMP system in this recent crop of discoveries," said Newton-Cheh, an assistant professor of Medicine at Harvard Medical School. "The greatest attention in blood pressure research has been focused on another pathway called the renin-angiotensin-aldosterone system (RAAS), which is targeted by several hypertension therapies. But only one common gene variant has been associated with genes in the RAAS pathway.

"Finding several independent associations that converge on cGMP points to its central importance in blood pressure control," he adds. "In fact, there are several drugs that target these systems in development to treat pulmonary hypertension and heart failure, but our findings suggest that they could have a much larger role in hypertension treatment in general. The next phase of our research will focus on finding additional genes and variants that influence blood pressure and on establishing how some of the cGMP-involved genes affect blood pressure in humans and respond to existing drugs and to those in development."


'/>"/>

Contact: Kristen Stanton
kstanton3@partners.org
617-643-3907
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Media invited: AVS 58th International Symposium and Exhibition
2. Mapping a model: International research on plant species appears in journal Nature
3. Systech International and Zetes Partner to Meet Europes Emerging Pharmaceutical Regulatory Requirements
4. Thermophile experts to hold international meeting Sept. 11-16 near Yellowstone National Park
5. International pharmacogenomics conference to focus on better drug treatment based on genetics
6. American Society of Human Genetics to host 12th International Congress of Human Genetics
7. Visiting researcher at IU leads international team in formal identification of new fungi class
8. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
9. Worlds largest sheep an international traveler
10. NYU Langone Medical Centers tip sheet to the 2011 Alzheimers Association International Conference
11. 19th Conference of the International Society for Sexually Transmitted Disease Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, ... the Internet of Things (IoT), today announced the appointment ... chief operating officer. Previously a strategic advisor to the ... and operations. Mr. Traynor is based out of the ... He reports to Chris Muench , Chief Executive ...
(Date:11/18/2014)... Nov. 17, 2014   News ... collaborate to develop The Partners Data Lake, an ... Partners Data Lake will allow researcher and clinicians ... treatment and the lives of patients , ... clinical activities across the Partners system, breaking down ...
(Date:11/15/2014)... -- While we may still be a few years away from ... to gain instant access to all that ailed his patients, ... tablets for monitoring and measuring our health are cropping up ... a tad Orwellian to some, but a new survey suggests ... opportunities into their healthcare regime. These are some ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... Life history traits are the basic ecological descriptors of ... mass and physiological traits, such as reproductive rate. Ecologists ... their role in determining the response of species to ... to anthropogenic stressors. Generation length is one of ...
... Sea level rise caused by global warming can prove extremely ... world,s biodiversity. Research by C. Bellard, C. Leclerc and ... look at 3 possible scenarios, from optimistic to very ... some of the richest biodiversity hotspots worldwide. The study was ...
... policies and practices, kids, diets improve. According to ... in the current issue of Childhood Obesity , ... or vending that were mostly or entirely healthful, students ... MSU associate professor of food, science and human nutrition. ...
Cached Biology News:Generation length for mammals: An essential reference point for conservation studies 2Island biodiversity in danger of total submersion with climate change 2Schools help kids choose carrots over candy bars 2
(Date:11/26/2014)... NC (PRWEB) November 25, 2014 ... Intensity Focused Ultrasound (HIFU) devices, recently participated in ... Small Renal Mass 360° .” Key opinion leaders ... therapeutic advances related to small renal masses while ... about different ablative technologies in hands-on labs. Attendees ...
(Date:11/26/2014)... Continuing its award-winning streak, Nerium International, the ... Awards for outstanding creative achievement by its marketing and ... the organization’s top honor, in the Branding category for ... April of this year. The event showcased top speakers ... was awarded a Gold MarCom Award in the Special ...
(Date:11/26/2014)... Global biostimulants market is expected to ... estimated CAGR of 12.5%. In order to cater ... least ecological impacts, farmers are looking to adopt ... yield more effectively & efficiently. Biostimulants are consequently ... return on investments. , Leading companies in the ...
(Date:11/26/2014)... MA (PRWEB) November 26, 2014 ... collaboration company is proud to announce that Darren Suders ... and Sales. Darren will drive the partner ... positive customer experience. , Darren brings more ... has held key roles in channel operations, from policy ...
Breaking Biology Technology:SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4SoundConnect Appoints Director of Channel Development & Sales 2
... Wis. -- Distance learning is about more than ... classroom, says Michael Schrage. Rather, technology is a medium ... taught, how it is taught, and what the relationship ... , ,Schrage, a research associate at MIT Media Lab ...
... A new 75,000-square-foot facility in the Dodge Industrial Park here ... company. , ,The company, API Inc., built the ... two offices that were in separate locations in Hartford. It ... gives the company, formerly known as Automated Peripherals Inc., more ...
... and its Fiserv EFT business unit on Wednesday announced ... growth rates in key transaction categories for the first ... ATM and point-of-sale (POS) processing business. Overall, Fiserv EFT ... over comparable 2004 volume of 2.02 billion. , ...
Cached Biology Technology:Schrage: Don't think of distance learning as just automation 2Schrage: Don't think of distance learning as just automation 3
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
SpectroQuest single beam 4nm UV/Vis spectrophotometer; stand-alone unit; large angled LCD screen; large sample compartment...
Size & Applications: 20 ml Storage Temp.: -20C Shelf Life: 12 months ...
... Immunogen: Synthetic peptide derived from ... protein (chromosome 17 open reading frame 37 ... for the C35 protein. On Western blots ... kDa band. Reactivity: Human (positive control: ...
Biology Products: