Navigation Links
International study identifies new gene targets for hypertension treatment
Date:9/11/2011

A new report from scientists at Massachusetts General Hospital (MGH) and their colleagues in centers around the world finds that common variants in 28 regions of DNA are associated with blood pressure in human patients. Of the identified regions, most were completely unsuspected, although some harbor genes suspected of influencing blood pressure based on animal studies. In the study receiving advance online publication in Nature, members of the International Consortium for Blood Pressure Genome-Wide Association Studies (ICBP-GWAS) analyzed genetic data from over 275,000 individuals from around the world. They also identified for the first time the involvement of an important physiologic pathway in blood pressure control, potentially leading to a totally new class of hypertension drugs.

"Identifying these novel pathways expands our current understanding of the determinants of blood pressure and highlights potential targets for new drugs to treat and prevent cardiovascular complications," says Christopher Newton-Cheh, MD, MPH, of the MGH Center for Human Genetic Research and the Cardiovascular Research Center, co-chair of the ICBP-GWAS Steering Committee and a senior and corresponding author on the Nature paper.

It is well known that hypertension can run in families and that some rare genetic syndromes raise blood pressure, but identifying genes associated with the common form of hypertension has been challenging. To get a study sample large enough to detect variants with modest effects, ICBP-GWAS researchers conducted a meta-analysis of 30 genome-wide association studies that included measurements of participants' blood pressures. Analysis of 2.5 million DNA sequence variants in more than 69,000 individuals of European ancestry identified several chromosomal regions where genes influencing blood pressure appeared to be located. To confirm the results of the first-stage analysis, the researchers genotyped the strongest variants in more t
'/>"/>

Contact: Kristen Stanton
kstanton3@partners.org
617-643-3907
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Media invited: AVS 58th International Symposium and Exhibition
2. Mapping a model: International research on plant species appears in journal Nature
3. Systech International and Zetes Partner to Meet Europes Emerging Pharmaceutical Regulatory Requirements
4. Thermophile experts to hold international meeting Sept. 11-16 near Yellowstone National Park
5. International pharmacogenomics conference to focus on better drug treatment based on genetics
6. American Society of Human Genetics to host 12th International Congress of Human Genetics
7. Visiting researcher at IU leads international team in formal identification of new fungi class
8. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
9. Worlds largest sheep an international traveler
10. NYU Langone Medical Centers tip sheet to the 2011 Alzheimers Association International Conference
11. 19th Conference of the International Society for Sexually Transmitted Disease Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... a newly coined term for novels and films which focus ... of Copenhagen shows how these fictions serve as a mental ... climate change and imagine other living conditions. , "Global ... the atmosphere; it is also a cultural phenomenon in which ... the films we see. And there are so many of ...
(Date:4/23/2014)... University of Exeter researcher has shed light on how ... in Australia,s remote outback have become reviled as pests ... of the Environment and Sustainability Institute at the University ... camel in Australia, from their historic role helping to ... as unwelcome "invader." , The deserts of the Australian ...
(Date:4/23/2014)... leading a 2 million Food Standards Agency (FSA) project ... and industry workers. , Norovirus outbreaks can rapidly ... batch of frozen strawberries infected 11,000 people in Germany, ... of which strains cause infection and which foods are ... , Researchers will produce data that will help the ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3How Australia got the hump with 1 million feral camels 2How Australia got the hump with 1 million feral camels 3
... States, (U.S.) predominance in science and technology (S&T) eroded ... China and South Korea--rapidly increased their innovation capacities. According ... Board (NSB), the policy making body of the National ... and Congress, the major Asian economies, taken together, now ...
... , This news release is available in ... transmission at the synapse between neurons is a highly complex, but ... voltage change, the so-called action potential, reaches the synaptic terminal in ... presynaptic neuron. This influx leads to a rise in the intracellular ...
... led by scientists from the University of California, San ... a protein that broadly regulates how genetic information transcribed ... ultimately translated into the myriad of proteins necessary for ... Cell Reports , help explain how a relatively ...
Cached Biology News:US lead in science and technology shrinking 2US lead in science and technology shrinking 3US lead in science and technology shrinking 4Loose coupling between calcium channels and sensors 2Global regulator of mRNA editing found 2
(Date:1/14/2014)... Carahsoft and CDS Federal Services have ... at 2pm EST (11am PST), “Natural Language Processing: Converting ... how technology can turn raw, heterogeneous data into actionable ... The online webinar will last approximately one hour. , ...
(Date:1/14/2014)... pet owners drew up their lists of New Year,s resolutions for ... of my furry companion." Nowadays there are pet salons, dog and ... take the little canine or feline darlings along wherever mommy or ... pricey toys at the pet store. But anyone who has ever ...
(Date:1/14/2014)... DIEGO and BETHESDA, Md. ... are joining together with two institutes from the National ... reliable tools for bringing safer, more effective treatments to ... the National Center for Advancing Translational Sciences (NCATS) and ...
(Date:1/14/2014)... Jan. 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), ... commercializing innovative therapies addressing major unmet medical needs ... the Notice of Allowance from the United States ... RNAi compounds (sd-rxRNA®), for the treatment of fibrosis. ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... LAUSANNE, Switzerland, September 3 Debiopharm Group, ... with,a focus on the development of prescription drugs ... Life Sciences Award, to Dr Lluis,Quintana-Murci from the ... in the emerging field of evolutionary genetics of,infection. ...
... JERUSALEM, September 3 Oramed Pharmaceuticals,Inc. (OTC ... systems, announced today that Nadav Kidron, its Chief Executive,Officer, is ... Conference on Friday September 11, 2009 at 10:00 a.m. EDT. ... in New York City. , Nadav ...
... , , BEIJING, Sept. 3 ... President Chung Leik Kok, announced today the signing of two (2) ... and Chemical Co., Ltd. (Beijing Oil & Gas). Fauve Intertrade is ... Miami, Florida; and Kuala Lumpur, Malaysia - with offices opening in ...
Cached Biology Technology:The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 2The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 3Oramed Pharmaceuticals to Present at Rodman & Renshaw 11th Annual Healthcare Conference 2Fauve Intertrade Signs Major Energy Contracts in China 2
Human DPPII/QPP/DPP7 Biotinylated Affinity Purified PAb ENTREZ GeneID: 29952...
Human SorCS1 Affinity Purified Polyclonal Ab Protein Family: Neurotrophins...
Human Apolipoprotein B100 Affinity Purified Polyclonal Ab ENTREZ GeneID: 338...
hypertension-related calcium-regulated gene, mRNA...
Biology Products: