Navigation Links
International study identifies new gene targets for hypertension treatment
Date:9/11/2011

A new report from scientists at Massachusetts General Hospital (MGH) and their colleagues in centers around the world finds that common variants in 28 regions of DNA are associated with blood pressure in human patients. Of the identified regions, most were completely unsuspected, although some harbor genes suspected of influencing blood pressure based on animal studies. In the study receiving advance online publication in Nature, members of the International Consortium for Blood Pressure Genome-Wide Association Studies (ICBP-GWAS) analyzed genetic data from over 275,000 individuals from around the world. They also identified for the first time the involvement of an important physiologic pathway in blood pressure control, potentially leading to a totally new class of hypertension drugs.

"Identifying these novel pathways expands our current understanding of the determinants of blood pressure and highlights potential targets for new drugs to treat and prevent cardiovascular complications," says Christopher Newton-Cheh, MD, MPH, of the MGH Center for Human Genetic Research and the Cardiovascular Research Center, co-chair of the ICBP-GWAS Steering Committee and a senior and corresponding author on the Nature paper.

It is well known that hypertension can run in families and that some rare genetic syndromes raise blood pressure, but identifying genes associated with the common form of hypertension has been challenging. To get a study sample large enough to detect variants with modest effects, ICBP-GWAS researchers conducted a meta-analysis of 30 genome-wide association studies that included measurements of participants' blood pressures. Analysis of 2.5 million DNA sequence variants in more than 69,000 individuals of European ancestry identified several chromosomal regions where genes influencing blood pressure appeared to be located. To confirm the results of the first-stage analysis, the researchers genotyped the strongest variants in more t
'/>"/>

Contact: Kristen Stanton
kstanton3@partners.org
617-643-3907
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Media invited: AVS 58th International Symposium and Exhibition
2. Mapping a model: International research on plant species appears in journal Nature
3. Systech International and Zetes Partner to Meet Europes Emerging Pharmaceutical Regulatory Requirements
4. Thermophile experts to hold international meeting Sept. 11-16 near Yellowstone National Park
5. International pharmacogenomics conference to focus on better drug treatment based on genetics
6. American Society of Human Genetics to host 12th International Congress of Human Genetics
7. Visiting researcher at IU leads international team in formal identification of new fungi class
8. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
9. Worlds largest sheep an international traveler
10. NYU Langone Medical Centers tip sheet to the 2011 Alzheimers Association International Conference
11. 19th Conference of the International Society for Sexually Transmitted Disease Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... -- You,ve been here before: you desperately need to sign ... site key or the answer to your secret question. What,s ... Today, Hoyos Labs , a digital infrastructure ... put an end to the frustration that comes with usernames, ... leverages a user,s smartphone to acquire his or her biometrics ...
(Date:12/10/2014)... , Dec. 9, 2014 CIE San Diego ... that provides the connective tissue that enhances care coordination ... to easily share client-level information; earned a second $1 ... to organizations serving seniors aging in community and; will ... on December 11 th 4-6p. CIE ...
(Date:12/5/2014)... Dec. 4, 2014 Increased emphasis on ... in new testing and inspection technologies. The convergence ... to a range of innovative test solutions. This ... Generation Y, which is generally more inclined towards ... product development strategies of test equipment vendors will ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... the Mississippi River and other areas are altering their ... researcher from Iowa State University. Fred Janzen, a ... turtle nesting habits and also accumulated research going back ... turtles to find out when they make nests and ...
... we are and how we play with others, but recent ... that the interaction between genes and behavior is more of ... is not a new idea to neuroscience, but one that ... professor Gene Robinson, lead author of a review on the ...
... Sea snakes may slither in saltwater, but they sip ... Florida zoologist in a paper appearing this month in ... journal Physiological and Biochemical Zoology . Harvey ... the roughly 60 species of venomous sea snakes worldwide ...
Cached Biology News:Turtles alter nesting dates due to temperature change says ISU researcher 2Social interactions can alter gene expression in the brain, and vice versa 2Social interactions can alter gene expression in the brain, and vice versa 3Zoologists: Sea snakes seek out freshwater to slake thirst 2Zoologists: Sea snakes seek out freshwater to slake thirst 3
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument ... Buffers, Valves, Guages, Seals), Accessories, Services, End User ... 2019” provides a detailed overview of the major ... strategies impacting the preparative and process chromatography market ... revenue and share analysis. , Full Copy ...
(Date:12/24/2014)... December 23, 2014 On Friday, ... H.R. 83, the Omnibus and Continuing Resolution Appropriations ... made hydrocephalus a condition eligible to receive funding ... administered by the Department of Defense (DoD). The ... allies on Capitol Hill, is celebrating this victory ...
(Date:12/24/2014)... The report expects global cell isolation ... It also provides a carefully analyzed data about the ... the market. , Full Copy of Report @ ... market for cell expansion will keep witnessing growth at ... growth to be driven by rapid technological advancements, government ...
(Date:12/24/2014)... 2014 PharmaBoardroom,s new report, ... and available for free download , digs deep into ... growth in the sector today. One area where ... been in developing a homegrown pharmaceutical manufacturing base, even if ... remains some way off. A cursory comparison with neighboring ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... March 29, 2011 AMDeC, LLC ... Program to include products offered by Sigma® Life ... of Sigma-Aldrich® (Nasdaq: SIAL).  AMDeC is a consortium ... New York region that is focused on increasing ...
... 2011 Tibotec Pharmaceuticals announced today that four abstracts ... C protease inhibitor, have been accepted for presentation at ... the Study of the Liver (EASL) in Berlin, Germany, ... The four abstracts for TMC435 support Tibotec,s continued efforts ...
... 29, 2011 Soligenix, Inc. (OTC Bulletin Board: ... biopharmaceutical company, announced today its financial results for the ... revenues for the year ended December 31, 2010 were ... representing a decrease of $868,409, or 31%.  During 2009, ...
Cached Biology Technology:Sigma® Life Science Joins AMDeC's Vendor Partnership Program, Further Enhancing Value to Academic Medical Research Centers 2Sigma® Life Science Joins AMDeC's Vendor Partnership Program, Further Enhancing Value to Academic Medical Research Centers 3Sigma® Life Science Joins AMDeC's Vendor Partnership Program, Further Enhancing Value to Academic Medical Research Centers 4Tibotec Advances Global Clinical Research Program for TMC435 in HCV; Will Present Four Abstracts Evaluating Safety and Efficacy at EASL 2Tibotec Advances Global Clinical Research Program for TMC435 in HCV; Will Present Four Abstracts Evaluating Safety and Efficacy at EASL 3Soligenix Reports Year-End 2010 Financial Results and Highlights Recent Accomplishments 2Soligenix Reports Year-End 2010 Financial Results and Highlights Recent Accomplishments 3Soligenix Reports Year-End 2010 Financial Results and Highlights Recent Accomplishments 4Soligenix Reports Year-End 2010 Financial Results and Highlights Recent Accomplishments 5
... for the rapid purification of linear 100 bp ... DNA band is excised from an,agarose gel and ... base of the column are a series of ... back while allowing DNA to selectively pass through ...
... is Tecans state-of-the-art software for all your ... scheduling in a single, scalable software package. ... consistent, simplifying the control of all Freedom ... Freedom EVO 100 with one liquid handling ...
...
... Isolation Kit provides all the reagents ... vesicle fraction. The isolation procedure involves ... synaptosomes, and differential centrifugation followed by ... also contains an antibody specific for ...
Biology Products: