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International public-private partnership offers new paradigm for medicinal chemistry
Date:12/19/2008

within industry together with the biological expertise within academia to address an emerging area of biology. In this regard, the initiative may provide an excellent model for future interactions between academia and industry in the area of "pre-competitive chemistry".

"Well characterised chemical probes are hugely useful for target validation and exploration of biology," said Dr Patrick Vallance, senior vice-president of Drug Discovery at GSK. "This link between the academic community and GSK in an emerging area of science should enhance knowledge and ultimately support our efforts to develop more medicines of benefit to patients."

In keeping with SGC policy, the structure and function of each probe will promptly be made freely available. Traditionally, pharmaceutical compounds have often only been released for public use after the relevant drug development program has been completed. It was thought that releasing an early-stage inhibitor would hamper further research in the corresponding area by the pharmaceutical sector, but history shows that the pharmaceutical industry is far more likely to pursue a drug discovery programme if there are already well-characterised inhibitors with defined mechanisms of action available.

The NCGC, led by its director, Dr Christopher Austin, will make several contributions to the project, from assay development to high-throughput screening to medicinal chemistry.

"This is a unique collaboration bringing together the chemistry might of a large pharmaceutical company with cutting edge activities in the academic sector to deliver chemical probes to the global scientific community," says Dr Chas Bountra, Chief Scientist at SGC in Oxford. "I believe this venture creates a paradigm shift as GSK opens up its internal chemistry capability to create new chemical probes that can be freely used by all academic and industrial scientists."

"Industry and academia both stand to benefit from this r
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Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

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