Navigation Links
International gene therapy trial for 'bubble boy' disease shows promising early results
Date:12/7/2013

negative impact on cognitive function. Seeking to explore whether transplants and specifically the intensity of transplant-related chemotherapy and radiation might be associated with cognitive decline, investigators conducted a prospective study, measuring cognitive function in transplant patients and healthy controls at similar intervals. In addition, the investigators measured the relative length of telomeres (protective protein structures on the ends of human chromosomes) in allogeneic HSCT recipients before transplant, hypothesizing that HSCT recipients with shorter telomeres would demonstrate reduced cognitive function after transplant.

To test their hypothesis, researchers assessed several cognitive parameters (e.g., multi-tasking, visual memory, recall) before transplant and at six, 12, and 24 months post-transplant in HSCT recipients and at the same intervals in the control group and found a significant association between shortened telomeres and reduced cognitive ability. Researchers also observed that those HSCT recipients who received full-intensity HSCT reported worse cognitive function than those who received reduced-intensity HSCT. In fact, the cognitive function in patients with reduced-intensity transplants remained comparable to that in the healthy controls. The cognitive decline observed was specifically linked to the shortening effect of these treatments on the length of telomeres.

"This study strongly indicates that patients who receive reduced-intensity transplants are generally spared from significant impact on their cognitive abilities, while full-intensity conditioning contributes to meaningful changes in multiple cognitive domains," said study author Alysia Bosworth of City of Hope in Duarte, Calif. "As our results isolate a specific group of patients who would be considered 'high risk' for cognitive impairment, including those who receive full-intensity transplants, it will be important for clinicians to evaluate and o
'/>"/>

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-3110
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3 4 5 6 7

Related biology news :

1. Ultracold matter technology from CU and SRI International licensed to Boulders ColdQuanta
2. International Polar Year conference: From knowledge to action
3. Large international study finds memory in adults impacted by versions of 4 genes
4. International team uncovers new genes that shape brain size, intelligence
5. Southampton researchers lead 2 international projects to help people out of poverty
6. UCSD researchers: Where international climate policy has failed, grassroots efforts can succeed
7. Washington University receives $8 million to lead international childhood malnutrition effort
8. Early Bird Discounts Available on International Healthcare and Biotechnology Conferences, Save Up To $600 with Global Information
9. New HealthFocus® International Study Reveals Five Very Different Weight Management Consumers
10. OU scientists and international team deciper the genetic code of the tomato
11. Digicel Launches Worlds First Biometric Identification System For International Money Transfers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
International gene therapy trial for 'bubble boy' disease shows promising early results
(Date:6/17/2015)... Maryland , June 17, 2015 ... mit DNA-Tests verbessert den Analyseprozess und senkt Laborkosten    ... Prime Standard: QIA) hat heute in den ... ® für die forensische Analyse ... zur Erstellung genetischer Fingerabdrücke bieten eine integrierte Lösung für ...
(Date:6/16/2015)... 16, 2015  With the increasing number and severity ... top concern. The recent compromise of Federal employee ... strong authentication within government agencies. HYPR Corp. ... password (OTP) authenticator, has been submitted for testing and ... 3 validation for tamper proofing. The ...
(Date:6/15/2015)... 15, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market, announces that its leading payment security ... at Digital Experience! @ NYC June 18th. Digital ... latest innovation in technology to over 300 of the top ... the Metropolitan Pavilion in New York City ...
Breaking Biology News(10 mins):QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
... effort to achieve breakthrough innovations in energy production, U.S. Deputy ... up to $122 million over five years to a multidisciplinary ... aimed at developing revolutionary methods to generate fuels directly from ... (JCAP), to be led by the California Institute of Technology ...
... clear of crocodiles and navigating around massive submerged trees, ... 25 freshwater pools of Cara Blanca, Belize, which were ... May, the divers found fossilized animal remains, bits of ... an enormous underwater cave. [Click here to ...
... This release is available in German ... have successfully measured in the ozone layer the chlorine ... ozone depletion. The doubts in the established models of ... laboratory measurements are disproved by these new atmospheric observations. ...
Cached Biology News:California team to receive up to $122 million to develop method to produce fuels from sunlight 2California team to receive up to $122 million to develop method to produce fuels from sunlight 3Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 2Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 3Key compound of ozone destruction detected 2
(Date:7/3/2015)... 2015 Forskere kan ... in Science", som finner sted i ... nett, på  http://www.openinnovationinscience.at , og søknadsperioden varer ... De to største utfordringene innen helsevitenskapen er ... forskningsspørsmål og kompleksiteten av nåværende forskningsresultater, i ...
(Date:7/3/2015)... , July 3, 2015 ... den 22. september 2015 på  http://www.openinnovationinscience.at ... Science", der finder sted i ... nylig undersøgelse af internationale forskere og videnskabsmænd ... de to største udfordringer for sundhedsvidenskaben manglen ...
(Date:7/2/2015)... ELLYN, Ill. , July 2, 2015 ... Colton Eakins are gaining invaluable real-world experiences ... of Technology this summer. The students will ... Dr. Jeff Wereszczynski,s research group at IIT. The ... Dr. Tom Carter , Physics; Dr. Kathy ...
(Date:7/2/2015)... -- Amici Procurement Migrates to the Cloud ... has chosen Microsoft Cloud Solution Provider iomart ...      (Logo: http://photos.prnewswire.com/prnh/20121126/579634) , ... the bio-tech sector with a unique procurement service, helping ... help them obtain best value. Its IT platform hosts ...
Breaking Biology Technology:Lansering av verdens første Open Innovation-program for utdanning av forskere 2Lansering av verdens første Open Innovation-program for utdanning av forskere 3Lancering af verdens første åbne innovationsprogram til uddannelse af forskere 2Lancering af verdens første åbne innovationsprogram til uddannelse af forskere 3COD Students Participate in Prestigious Summer Internships 2Biotech Procurement Company Moves to Office 365 with iomart 2
... Sept. 8 CeloNova BioSciences, Inc.,("CeloNova"), a ... the world,s first fully color-coded line of ... meeting of the,Cardiovascular and Interventional Radiology Society ... http://www.newscom.com/cgi-bin/prnh/20070908/CLSA008 ) Embolic microspheres ...
... 2007, Wyeth (NYSE: WYE ) will announce financial ... a one-hour conference call with,research analysts at 7:30 a.m. ... may listen to the call live or on a ... by visiting our website,at http://www.wyeth.com and clicking ...
... /Xinhua-PRNewswire-FirstCall/ -- China Technology,Development Group Corporation (Nasdaq: ... new business strategy of entering the booming ... significantly increase China,s,use of renewable energy in ... strongly believes the new business strategy will ...
Cached Biology Technology:CeloNova BioSciences Announces World's First Line of Fully Color-Coded Embolic Particles at CIRSE: Embozene(TM) Color-Advanced Microspheres 2China Technology Announces Entry to the Solar Energy Sector 2China Technology Announces Entry to the Solar Energy Sector 3
... a base medium for preparation of minimal and ... but does not contain amino acids. Both bulk ... pouch contains reagents to prepare 500 ml of ... of 10X YNB for S. cerevisiae media. Store ...
... Progesterone Receptor (PR) Competitor Assay Kits ... novel progesterone receptor binding compounds using ... utilizes a fusion of glutathione transferase ... human progesterone receptor [PR-LBD(GST)] and a ...
... Protein G bind specifically to Fc regions ... Protein G conjugates are commonly used as ... immunoglobulin subtypes from serum, hybridoma ascites fluids, ... These reagents are also commonly used to ...
... the first instrument engineered to match the ... by thousands of research centers worldwide. It ... which are ideally suited for high-speed temperature ... extremely high surface-area-to-volume ratio. ,By combining glass ...
Biology Products: