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International gene therapy trial for 'bubble boy' disease shows promising early results
Date:12/7/2013

were also no statistically significant differences in the risks of non-relapse death or severe graft-versus-host disease.

"The similarly positive outcomes we observed among patients in their 50s, 60s, and 70s clearly illustrate that advanced age need no longer be a significant barrier to successful outcomes after half-matched BMT," said study author Yvette Kasamon, MD, of the Johns Hopkins Kimmel Cancer Center in Baltimore. "These results underscore that a reduced-intensity, related haploidentical transplant should be considered a very reasonable treatment option for suitable patients up to at least age 75 who require a transplant."

Dr. Kasamon will present this study during an oral presentation at 5:15 p.m. CST on Sunday, December 8, in Rooms 208-210 of the Ernest N. Morial Convention Center.

Equality of Access to Transplant for Ethnic Minority Patients Through Use of Cord Blood and Haploidentical Transplants [2138]

Previous studies have shown that minorities are poorly represented in international donor panels and therefore minority patients are often unable to find a suitable donor. While the number of registered donors has increased significantly in recent years and the use of cord blood and haploidentical transplants as treatment solutions for minority patients has expanded, the impact of these strategies remains largely unclear.

In an attempt to evaluate these advancements, this study followed 332 transplant patients who had been referred to Anthony Nolan Research Institute, the organization that manages the United Kingdom's stem cell donor registry. Three-quarters of the patients were white Northern European (WNE) and the remaining 25 percent were non-white Northern European (non-WNE) with similar underlying disease. Researchers sought to determine differences between the two groups in terms of achieving transplant as well as
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Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-3110
Dana-Farber Cancer Institute
Source:Eurekalert  

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