Navigation Links
International consortium discovers seven new genomic regions associated with AMD
Date:3/3/2013

iscovered 12 loci, these seven loci are scattered throughout the genome on many different chromosomes.

"A large number of samples was needed to detect additional genetic variants that have small but significant influences on a person's disease risk," said Hemin Chin, PhD, NEI associate director for ophthalmic genetics, who assembled the consortium and helped coordinate the study. "By cataloging genetic variations associated with AMD, scientists are better equipped to target corresponding biological pathways and study how they might interact and change with age or other factors, such as smoking."

The consortium's analysis included data from more than 17,100 people with the most advanced and severe forms of AMD, which were compared to data from more than 60,000 people without AMD. The 19 loci that were found to be associated with AMD implicate a variety of biological functions, including regulation of the immune system, maintenance of cellular structure, growth and permeability of blood vessels, lipid metabolism and atherosclerosis.

As with other common diseases, such as type 2 diabetes, an individual person's risk for getting AMD is likely determined not by one but many genes. Further comprehensive DNA analysis of the areas around the 19 loci identified by the AMD Gene Consortium could turn up undiscovered rare genetic variants with a disproportionately large effect on AMD risk. Discovery of such genes could greatly advance scientists' understanding of AMD pathogenesis and their quest for more effective treatments.

AMD affects the macula, a region of the retina responsible for central vision. The retina is the layer of light-sensitive tissue in the back of the eye that houses rod and cone photoreceptor cells. Compared with the rest of the retina, the macula is especially dense with cone photoreceptors and is what humans rely on for tasks that require sharp vision, such as reading, driving and recognizing faces. As AMD prog
'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. 11th International Congress on Targeted Anticancer Therapies
2. WPI Biomedical Technology in final 4 of international business plan contest
3. Biologists lead international team to track Arctic response to climate change
4. International space station plays host to innovative infectious disease research
5. Maris presentation tops ANZFSS International Symposium
6. International biodiversity data symposium to mark the kickoff of the EU BON project
7. AERA announces publication of the International Handbook of Research on Environmental Education
8. Conference Programme Committees selected for the 20th International AIDS Conference (AIDS 2014)
9. Winners of 10th annual International Science & Technology Visualization Challenge announced
10. The 2013 International Conference on Genomics in Europe will take place in Ghent, Belgium
11. Flashback Data Remains Only Non-Governmental Digital Forensics Lab with ASCLD/LAB International Accreditation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... healthier for your neighbors than traditional cigarettes, but ... a new study from USC. , Scientists studying ... decrease in exposure to harmful particles, with close-to-zero ... to some harmful metals in second-hand e-cigarette smoke ... tobacco smoke contains high levels of polycyclic aromatic ...
(Date:8/28/2014)... A Mayo Clinic researcher and his collaborators have ... and enhance the process of re-engineering cells for biomedical ... network biology methods to aid stem cell engineering. Details ... are described in two back-to-back papers in the journal ... broad range of uses for all types of cell-based ...
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) Program ... Genetics Society of America,s 27th Annual Mouse Molecular ... 2014 in Pacific Grove, California. These awards ... post doctorates and scientists from underrepresented groups into ... to encourage the participation of young scientists at ...
Breaking Biology News(10 mins):Second-hand e-cig smoke compared to regular cigarette smoke 2New tool aids stem cell engineering for medical research 2
... is why mice engineered to have the abnormal protein ... the disease. Specifically, such mice are genetically altered to ... this protein that, when clipped by enzymes, produces the ... plaque that clogs the brain and kills brain cells. ...
... gene expression in the brain can differ significantly among ... study indicates that roughly 15 percent of Atlantic salmon ... their freshwater birthplaces to mature in oceans versus those ... , The researchers, at Harvard University, the University of ...
... pass on "traditions" to other members of their group, ... findings add to evidence that cultural learning is widespread ... Marineland in Niagara Falls in Ontario, Canada. An inventive ... and passed the strategy on to his tank-mates. The ...
Cached Biology News:Pinpointing a culprit molecule in Alzheimer's disease 2Divergent life history shapes gene expression in brains of salmon 2More animals join the learning circle 2
(Date:8/28/2014)... 28, 2014 Best Sanitizers, Inc., a ... food processing industry, is asking industry professionals to prepare ... of the E2 soap they’re currently using to the ... . Hand hygiene is critical to fighting cross-contamination ... environment. Six key criteria are identified to evaluate the ...
(Date:8/28/2014)... “This kit has an improved extraction efficiency and ... 150 ppb,” said Mark Tess, PhD, Mycotoxin Product Manager for ... owners and USDA-GIPSA inspection agencies that have a need to ... place in a matter of minutes with nothing but our ... feed and grain before accepting it, but they no longer ...
(Date:8/28/2014)... are important devices in spintronics, an electronic which ... electrons but also on their spin and the ... electric into magnetic signals and vice versa. Recently, ... the Institute of Physics at Johannes Gutenberg University ... Prague, and Japan, has for the first time ...
(Date:8/28/2014)... 28, 2014 The ability for organizations ... that will allow individuals to perform at the highest ... for employers looking to compete in this post–recession era. ... this trend, as the sector increasingly focuses on the ... which will have real results on the organization's development ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3
... March 17 Spiral Biotech, an Advanced Instruments ... Plating System -- which delivers faster cycle ... that boost processing speed and efficiency in microbiology ... (ASM) General Meeting in May, 2009."The introduction of ...
... Cardiorobotics, Inc., a medical device ... a wide range of applications, including: medical, industrial, ... Dr. Samuel Straface in the position of President ... Straface has joined Cardiorobotics in this executive leadership ...
... Novavax, Inc. (Nasdaq: NVAX ) today announced that ... a press release to be issued after 8:00 a.m. Eastern ... investor conference call to discuss its financial results at 10:00 ... be hosted by Novavax President and Chief Executive Officer Dr. ...
Cached Biology Technology:Spiral Biotech to Introduce New Autoplate Spiral Plating System at ASM General Meeting in May 2Spiral Biotech to Introduce New Autoplate Spiral Plating System at ASM General Meeting in May 3Cardiorobotics Announces New CEO, PLSG Executive-in-Residence to Lead Company 2Cardiorobotics Announces New CEO, PLSG Executive-in-Residence to Lead Company 3Novavax Announces Release Date of 2008 Fourth Quarter Financial Results and Investor Conference Call 2Novavax Announces Release Date of 2008 Fourth Quarter Financial Results and Investor Conference Call 3
... Faster speeds, highest precision, more ... flexible concept: this is the definition of ... few years nucleic acid research has been ... capabilities required of PCR Systems. To ...
... genomics-based research with S. aureus, Sigma-Genosys has developed ... primers to amplify all open reading frames (ORFs) ... are included to amplify ORFs that are unique ... S. aureus. The ORFmer set contains primers to ...
... The Bio-Stack Twister II Microplate Handler ... automation solution for integrating BioTeks washers, ... with expandable microplate capacity, ultimate flexibility ... you are adding capacity to single ...
... Purification Kits enable rapid analytical to medium ... produced from appropriate vectors. Sufficient reagents are ... mg target protein under native or denaturing ... Agarose, which specifically retains STag fusion proteins. ...
Biology Products: