Navigation Links
International collaboration highlights new mechanism explaining how cancer cells spread
Date:5/28/2014

DALLAS May 28, 2014 UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer.

The protein, Aiolos, is produced by normal blood cells but commits a kind of "identity theft" of blood cells when expressed by cancer cells, allowing the latter to metastasize, or spread, to other parts of the body. Metastatic cancer cells have the ability to break free from tissue, circulate in the blood stream, and form tumors all over the body, in a way acting like blood cells.

"This is an important discovery because the metastatic spread of tumors accounts for the vast majority of cancer-related deaths. Now that we know the role of Aiolos, we can look toward therapeutic intervention," said Dr. Lance Terada, Professor of Internal Medicine and Chief of the Division of Pulmonary/Critical Medicine at UT Southwestern.

The research, available online and in the journal Cancer Cell, found that Aiolos, which frequently is expressed in lung cancers, is a predictor of a markedly worse prognosis in lung cancer patients.

Aiolos is a member of a class of proteins called transcription factors proteins that control which genes are turned on or off by binding to DNA and other proteins. Once bound to DNA, these proteins can promote or block the enzyme that controls the reading, or "transcription," of genes, making genes more or less active.

Aiolos decreases the production of cell adhesion proteins and disrupts critical cell adhesion processes, including processes that allow tissue cells to anchor to their physical environment, a necessary requirement for cells to survive and spread. Metastatic cells don't need this adhesion, allowing them to proliferate instead. Aiolos also represses another protein called p66Shc, whic
'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Ultracold matter technology from CU and SRI International licensed to Boulders ColdQuanta
2. International Polar Year conference: From knowledge to action
3. Large international study finds memory in adults impacted by versions of 4 genes
4. International team uncovers new genes that shape brain size, intelligence
5. Southampton researchers lead 2 international projects to help people out of poverty
6. UCSD researchers: Where international climate policy has failed, grassroots efforts can succeed
7. Washington University receives $8 million to lead international childhood malnutrition effort
8. Early Bird Discounts Available on International Healthcare and Biotechnology Conferences, Save Up To $600 with Global Information
9. New HealthFocus® International Study Reveals Five Very Different Weight Management Consumers
10. OU scientists and international team deciper the genetic code of the tomato
11. Digicel Launches Worlds First Biometric Identification System For International Money Transfers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
International collaboration highlights new mechanism explaining how cancer cells spread
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays a ... while. Hypertension – the medical term for high blood pressure ... 1800s, and the inflatable cuff that,s used in measuring blood ... mean there,s nothing new about hypertension, its triggers and its ... about the condition and the best ways to treat it. ...
(Date:12/10/2014)... 2014 You,ve been here before: you desperately need ... your password, site key or the answer to your secret ... teacher? Today, Hoyos Labs , a ... will finally put an end to the frustration that comes ... . 1U leverages a user,s smartphone to acquire his or ...
(Date:12/10/2014)... 9, 2014  Wake Forest Baptist Medical Center today announced ... School of Medicine. Funding for this $50 million capital ... will be publicly launched next summer. ... former 60 series R.J. Reynolds Tobacco Company complex, adjacent ... begin immediately with plans to be ready to welcome ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... and accumulating calcium carbonate, and this is essential for ... An international research team has discovered that the amount ... is now significantly below rates measured over recent geological ... 70% lower. Coral reefs form some of ...
... end of the last Ice Age, trees have had thousands ... will forests adapt to the rapid pace of current climate ... grant to Drs. Stephen Keller, Andrew Elmore, Matthew Fitzpatrick, David ... for Environmental Science,s Appalachian Laboratory to study climate adaptation in ...
... observational technique have determined the precise configuration of humulones, ... flavor. That might not sound like a big ... results reported in scientific literature in the last 40 ... diabetes, some types of cancer and other maladies. ...
Cached Biology News:New evidence highlights threat to Caribbean coral reef growth 2New evidence highlights threat to Caribbean coral reef growth 3New study will predict how trees will adapt to rapid climate change 2Beer's bitter compounds could help brew new medicines 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced ... , a network of more than 20 contributing ... have fast access to a national pool of frozen ... Fertility Associates of Memphis is the only fertility clinic ... , Dr. William Kutteh , director of Fertility ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the nation’s ... Pharm.D. to the newly created position of Vice President ... Dr. Maroulis will continue to manage the entire specialty ... pharmacies as the company expands. Dr. Maroulis has been ... has served in many different capacities in the pharmacy, ...
(Date:12/19/2014)... , Dec. 19, 2014 Bina Technologies, Inc. ... announced today that they have been acquired by Roche ... is a privately held company that provides a big ... generation sequencing (NGS) data for the academic and translational ... Sequencing Unit, and will continue to focus on development ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Mass.--A mat of nanowires with the touch and feel of paper ... and other organic pollutants, MIT researchers and colleagues report in the ... they have created a membrane that can absorb up to 20 ... for future use. The oil itself can also be recovered. Some ...
... Holliday Updates Investors on Growth Opportunities, NEW ... today, DuPont Chairman and CEO Charles O. Holliday, ... innovation that addresses,global macro trends related to food, ... a market-driven science company," Holliday said at the,Sanford ...
... By Improving the Accuracy of Tumor Grading, MapQuant Dx(TM) Genomic ... Chemotherapy Treatments per Year ... 2008 - booth 23128, CHICAGO, May 30 Ipsogen ... that markets molecular diagnostic assays,for leukaemia announced today that it ...
Cached Biology Technology:MIT develops a 'paper towel' for oil spills 2DuPont Well Positioned for Long-Term Growth in Agricultural Productivity, Safety and Security, Renewable Energy 2DuPont Well Positioned for Long-Term Growth in Agricultural Productivity, Safety and Security, Renewable Energy 3Ipsogen Launches MapQuant Dx(TM) Genomic Grade Test to Identify Breast Cancer Patients who Benefit From Chemotherapy 2Ipsogen Launches MapQuant Dx(TM) Genomic Grade Test to Identify Breast Cancer Patients who Benefit From Chemotherapy 3Ipsogen Launches MapQuant Dx(TM) Genomic Grade Test to Identify Breast Cancer Patients who Benefit From Chemotherapy 4
MOUSE ANTI SIMIAN VIRUS 5 Immunogen: Simian virus 5...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
... Purification Kit is designed to purify double-stranded DNA ... synthesis and PCR. The process is simple and ... 3 g can be efficiently purified and concentrated. ... DNA is bound to the Microfilter Cartridge in ...
Biology Products: