Navigation Links
International collaboration finds 11 new Alzheimer's genes to target for drug discovery
Date:10/27/2013

MIAMI -- University of Miami Miller School of Medicine researchers played a key role in the largest international Alzheimer's disease genetics collaboration to date, which identified 11 new regions of the genome that contribute to late-onset Alzheimer's disease, doubling the number of potential genetics-based therapeutic targets to investigate. Published October 27 in Nature Genetics, the study gives a broader view of the genetic factors contributing to Alzheimer's and expands the understanding of the disease to new areas, including the immune system, where a genetic overlap with other neurodegenerative diseases, including multiple sclerosis and Parkinson's disease, was identified.

In 2011, the world's four largest research consortia on the genetics of Alzheimer's disease joined efforts to discover and map the genes that contribute to Alzheimer's, forming the International Genomics of Alzheimer's Project (IGAP). The team collected genetic information from 25,500 Alzheimer's disease patients and 49,038 controls from 15 countries to perform this two-stage meta-analysis that resulted in the discovery of 11 new genes in addition to those already known, and the identification of 13 other genes, yet to be validated.

Margaret A. Pericak-Vance, Ph.D., the Dr. John T. Macdonald Foundation Professor of Human Genomics and Director of the John P. Hussman Institute for Human Genomics at the Miller School, and Lindsay A. Farrer, Ph.D., from Boston University, led the analysis teams for the American Alzheimer's Disease Genetics Consortium, which includes nearly all of the nation's researchers working on the genetics of Alzheimer's, as well as many investigators and resources of the 29 federally funded Alzheimer's Disease Centers.

Several of the genes the researchers identified confirmed known biological pathways of Alzheimer's disease, including the role of the amyloid (SORL1, CASS4) and tau (CASS4, FERMT2) pathways. Newly discovered genes i
'/>"/>

Contact: Alexandra Bassil
a.bassil@miami.edu
305-284-1092
University of Miami
Source:Eurekalert

Page: 1 2

Related biology news :

1. PETA and its international affiliates launch not-for-profit international science company
2. Stepping up the Pace: 20th International AIDS Conference (AIDS 2014) theme selected
3. International Niels Bohr Conference: An open world
4. Celiac research to highlight international symposium
5. New research on potential avocado health benefits presented at International Congress of Nutrition
6. International experts to explore new wonderdrug at conference
7. International Rett Syndrome Foundation chief science officer receives prestigious military awards
8. SmartMove, Inc. receives $200,000 grant from the Colorado Office of Economic Development and International Trade
9. Researchers describe potential for MERS coronavirus to spread internationally
10. UChicago Celiac Disease Center to host international symposium
11. MARC travel awards announced for the GSA: 19th International C. elegans Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... Yale University researchers are studying a potential new ... respiratory disease in which scars develop in the lungs ... microRNA mimic, miR-29, which is delivered to lung tissue ... fibrosis, it reversed fibrosis after several days. , ... EMBO Molecular Medicine . , "The mimic, when ...
(Date:9/22/2014)... New Rochelle, NY, September 22, 2014Cassava, also known as ... high yields in areas of Africa, Asia, and Latin ... With the availability of novel enzymes and processes designed ... then be used to produce sweeteners such as glucose, ... alternative to corn, as described in a Review article ...
(Date:9/22/2014)... manufacture their own "antifreeze" proteins to survive in ... side effect, researchers report: The protein-bound ice crystals ... when temperatures warm. , The finding is ... Academy of Sciences . , "We discovered what ... evolution of antifreeze proteins in Antarctic notothenioid fishes," ...
Breaking Biology News(10 mins):Reversing the effects of pulmonary fibrosis 2Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 2Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 3
... Honeybees can learn to avoid nectar containing natural plant ... scientists at Newcastle University have found. This means that ... such as almond or apple orchards bees struggle to find ... toxic nectar. With honeybee populations already under stress, the Newcastle ...
... NEW YORK CITY (December 20, 2010)The New York Stem ... member of the inaugural class of NYSCF-Robertson Investigators, who was ... the December 27, 2010 Person of the Year Issue. ... School, was lauded for his discovery of an innovative method ...
... environmental factors cause the diversityor numberof species to increase ... suggested that species diversity continues instead of entering into ... in the Caribbean not only supports the original theory ... resources all work together to achieve equilibrium; it builds ...
Cached Biology News:Bee challenged -- toxin-laden nectar poses problems for honeybees 2Time Magazine names Derrick Rossi to 2010 list of 'People Who Mattered' 2Research shows that environmental factors limit species diversity 2
(Date:9/23/2014)... Sept. 23, 2014 News Facts ... India devoted to genome-based research for human health ... is taking a bite out of oral cancer with ... in India with the help of ... DataDirect Networks (DDN). , To fuel its cutting-edge cancer ...
(Date:9/23/2014)... BOSTON, Mass. (PRWEB) September 23, 2014 ... driven by Semantic Web technology, was named in the ... by Gartner, Inc. , The report details key ... category. , According to Gartner analysts Michael Shanler ... help accelerate innovation activities, expose complex relationships with scientific ...
(Date:9/23/2014)... TX (PRWEB) September 23, 2014 Texas ... fertility clinic in South Austin, expanding a Central Texas ... and San Antonio. The satellite office for the region’s ... andrology options to the South Austin, Buda, Kyle and ... effective and affordable fertility treatment directly to individuals and ...
(Date:9/23/2014)... 23, 2014 Healthcare professionals, ... will convene at the Society for Integrative ... held October 26-28 in Houston, Texas to ... practice in individualized integrative cancer care. This ... psychologists, nutritionists, naturopaths, acupuncturists, and other complementary ...
Breaking Biology Technology:National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5Cambridge Semantics Identified in Gartner’s ‘Hype Cycle for Life Sciences 2014’ Report 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 3International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 3
... Feb. 24 Nektar Therapeutics,(Nasdaq: NKTR ... fourth quarter and,year ended December 31, 2008. , ... year for Nektar," said Howard W. Robin,President and ... unique polymer,conjugation chemistry platform, we advanced numerous proprietary ...
... and Play Capability of MyMedicalRecords Pro to ... Technology Experts Expected at HIMSS09LOS ANGELES, Feb. ... Bulletin Board: FVRL), which through its wholly-owned ... consumer-controlled Personal Health Records ("PHRs") ( www.mymedicalrecords.com ...
... Feb. 24 Particle Sciences Inc. today announced the ... from tissue hydration to the passivation of medical device ... series of patent-pending polymers that allow Particle Sciences to ... PS, Director of New Technologies.Particle Sciences has already used ...
Cached Biology Technology:Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 2Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 3Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 4Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 5Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 6Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 7Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 8Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 9MMR Seeks Its Slice of the Billion-Dollar Stimulus Pie 2MMR Seeks Its Slice of the Billion-Dollar Stimulus Pie 3MMR Seeks Its Slice of the Billion-Dollar Stimulus Pie 4MMR Seeks Its Slice of the Billion-Dollar Stimulus Pie 5Particle Sciences Completes Development of First Product Incorporating its Unique Surface Modification System 2
...
... offers the most comprehensive, cost-effective solution ... have incorporated unprecedented quality into both ... includes proven detection chemistries and antibodies ... TechMate protocol. It also includes our ...
... (X/R) Red System consists of concentrated ... and X/R Red Buffer. The X/R ... to produce red staining that may ... , Buffer, 100 mL , Chromogen, ...
Human Cell Line Slides...
Biology Products: