Navigation Links
International collaboration finds 11 new Alzheimer's genes to target for drug discovery
Date:10/27/2013

MIAMI -- University of Miami Miller School of Medicine researchers played a key role in the largest international Alzheimer's disease genetics collaboration to date, which identified 11 new regions of the genome that contribute to late-onset Alzheimer's disease, doubling the number of potential genetics-based therapeutic targets to investigate. Published October 27 in Nature Genetics, the study gives a broader view of the genetic factors contributing to Alzheimer's and expands the understanding of the disease to new areas, including the immune system, where a genetic overlap with other neurodegenerative diseases, including multiple sclerosis and Parkinson's disease, was identified.

In 2011, the world's four largest research consortia on the genetics of Alzheimer's disease joined efforts to discover and map the genes that contribute to Alzheimer's, forming the International Genomics of Alzheimer's Project (IGAP). The team collected genetic information from 25,500 Alzheimer's disease patients and 49,038 controls from 15 countries to perform this two-stage meta-analysis that resulted in the discovery of 11 new genes in addition to those already known, and the identification of 13 other genes, yet to be validated.

Margaret A. Pericak-Vance, Ph.D., the Dr. John T. Macdonald Foundation Professor of Human Genomics and Director of the John P. Hussman Institute for Human Genomics at the Miller School, and Lindsay A. Farrer, Ph.D., from Boston University, led the analysis teams for the American Alzheimer's Disease Genetics Consortium, which includes nearly all of the nation's researchers working on the genetics of Alzheimer's, as well as many investigators and resources of the 29 federally funded Alzheimer's Disease Centers.

Several of the genes the researchers identified confirmed known biological pathways of Alzheimer's disease, including the role of the amyloid (SORL1, CASS4) and tau (CASS4, FERMT2) pathways. Newly discovered genes involved in the immune response and inflammation (HLA-DRB5/DRB1, INPP5D, MEF2C) reinforced a pathway implied by previous work (on CR1, TREM2). Additional genes related to cell migration (PTK2B), lipid transport and endocytosis (SORL1) also were confirmed, and new hypotheses emerged related to hippocampal synaptic function (MEF2C, PTK2B), the cytoskeleton and axonal transport (CELF1, NME8, CASS4), as well as myeloid and microglial cell functions (INPP5D).

One of the more significant new associations was found in the HLA-DRB5/DRB1 region, one of the most complex parts of the genome, which plays a role in the immune system and inflammatory response. It also has been associated with multiple sclerosis and Parkinson's disease, suggesting that the diseases where abnormal proteins accumulate in the brain may have a common mechanism involved, and possibly a common drug target.

"The discovery of novel pathways is very encouraging considering the limited success of Alzheimer's disease drugs tested so far," Pericak-Vance said. "Our findings bring us closer toward identifying new drug targets for Alzheimer's and other neurodegenerative diseases. We'll continue to expand and analyze our data set with this incredible group so that we can better understand the genetic influences on this devastating disease, and find new medical and therapeutic interventions."


'/>"/>

Contact: Alexandra Bassil
a.bassil@miami.edu
305-284-1092
University of Miami
Source:Eurekalert

Related biology news :

1. PETA and its international affiliates launch not-for-profit international science company
2. Stepping up the Pace: 20th International AIDS Conference (AIDS 2014) theme selected
3. International Niels Bohr Conference: An open world
4. Celiac research to highlight international symposium
5. New research on potential avocado health benefits presented at International Congress of Nutrition
6. International experts to explore new wonderdrug at conference
7. International Rett Syndrome Foundation chief science officer receives prestigious military awards
8. SmartMove, Inc. receives $200,000 grant from the Colorado Office of Economic Development and International Trade
9. Researchers describe potential for MERS coronavirus to spread internationally
10. UChicago Celiac Disease Center to host international symposium
11. MARC travel awards announced for the GSA: 19th International C. elegans Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
(Date:3/30/2017)... HONG KONG , March 30, 2017 ... developed a system for three-dimensional (3D) fingerprint identification by adopting ground ... technology into a new realm of speed and accuracy for use ... applications at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:8/17/2017)... (PRWEB) , ... August 17, 2017 , ... ... cancer research and personalized medicine, today announced the launch of a new breast ... Missouri. The study’s goal is to evaluate the potential for early detection of ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... and Electrospraying line of nanofiber and nanoparticle fabrication instruments ... the lab to fully automated pilot plants and equipment for industrial manufacturing. ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... While art ... are much more closely connected than one might think. A Mesh Is Also ... open at the University City Science Center’s Esther Klein Gallery (EKG) on August 17 ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... and Drug Administration (FDA) inspection at our Dilworth, MN site. The inspection took ... This inspection was conducted as part of a routine Bioresearch Monitoring Program (BIMO) ...
Breaking Biology Technology: