Navigation Links
International collaboration by scientists culminates in novel ion channels database
Date:6/24/2009

An important resource consolidating understanding of the roles played by Ion channels in drug action is now available for scientists and students.

The International Union of Basic and Clinical Pharmacology (IUPHAR) announce the publication of a new ion channels database, covering both the voltage-gated (VGIC) and ligand-gated (LGIC) ion channels.

This represents a major addition to its existing mammalian receptor database, which is freely available at http://www.iuphar-db.org/.

The IUPHAR database, hosted by the Centre for Cardiovascular Science at University of Edinburgh, is a carefully curated and authoritative resource drawing together peer reviewed information about pharmacological, chemical, genetic, functional and patho-physiological properties of human, rat and mouse genes encoding in excess of 354 non sensory G protein-coupled receptors (GPCRs) including orphan receptors, 71 LGIC and 141 VGIC subunits.

This set of genes is known to encompass a third of current drug targets and a significant proportion of likely targets for the development of future medicines.

In keeping with the database's tradition, many leading research pharmacologists were closely involved in the data curation process, with Professors William A. Catterall (University of Washington) and George Gutman (University of California) taking leading roles for VGICs and Professors John A. Peters (The University of Dundee) and Richard Olsen (University of California, Los Angeles) for the LGICs.

The IUPHAR database is a major online reference resource and first-port-of-call for information about mammalian drug targets for students and scientists throughout the world, attracting approximately 2500 unique visitors to its website each week from 130 countries.

In this current release of receptor families, IUPHAR provides detailed information for 8 VGIC and 3 LGIC families. Curation of the remaining five ion channel gene families is underway. The ion channel database is now available at: http://www.iuphar-db.org/IC/ReceptorFamiliesForward.

IUPHAR also remains committed to the ongoing update of the GPCR database which has been publicly available since 2005. GPCR pages updated in the current release are melanin-concentrating hormone, estrogen and P2Y receptors.


'/>"/>

Contact: Chido Mpamhanga
curators@iuphar-db.org
University of Edinburgh
Source:Eurekalert

Related biology news :

1. Susan E. Gardiner receives ASHS Outstanding International Horticulturist Award
2. SRI International announces findings from new upper atmospheric radar system for scientific research
3. International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
4. World-class innovation through international cooperation
5. International team tracks clues to HIV
6. SRI International to screen drugs that fight 2009 H1N1 influenza A
7. SRI International receives $100,000 Grand Challenges Explorations grant
8. International team finds key gene that allows plants to survive drought
9. BIO-key(R) International Showcasing Biometric Identification Technology at 2009 RSA Conference
10. Canadian biomedical engineering pioneer receives international award
11. Major international study challenges notions of how genes are controlled in mammals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
(Date:6/2/2016)... , June 2, 2016 Perimeter ... Platforms, Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... market will generate revenues of $17.98 billion in 2016. ... DVTEL Inc, a leader in software and hardware technologies ...
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... ... 23, 2016 , ... UAS LifeSciences, one of the leading ... UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing high ... its list of well-respected retailers. This list includes such fine stores as Whole ...
(Date:6/23/2016)... SILVER SPRING, Md. , June 23, 2016 ... evidence collected from the crime scene to track the criminal ... sick, and the U.S. Food and Drug Administration (FDA) uses ... Sound far-fetched? It,s not. ... whole genome sequencing to support investigations of foodborne illnesses. Put ...
Breaking Biology Technology: