Navigation Links
International TGen-led team finds link between brain protein and Alzheimer's disease
Date:9/15/2008

e centers, including three European organizations representing German, Dutch and Norwegian populations.

Gene expression study

The gene expression study examined tissues from six regions of the brain among 47 deceased individuals. The brain tissue samples were provided by three Alzheimer's disease centers: Washington University in St. Louis, Mo.; Duke University in Durham, N.C.; and Sun Health Research Institute in Sun City, Ariz.

KIBRA, and a subset of other molecules directly interacting with it, were significantly altered in regions of the brain involved in Alzheimer's disease pathology. The regions investigated included the hippocampus, entorhinal cortex, posterior cingulate cortex, middle temporal gyrus, and superior frontal gyrus. However, they were not altered in a region of the brain typically unaffected by the disease -- the primary visual cortex.

Positron Emission Tomography scans

PET scans of 67 non-carriers of the KIBRA T-allele, and 69 carriers -- all with close relatives diagnosed with Alzheimer's -- showed that non-carriers exhibited, on average, similar alterations in the metabolic activity of key brain regions known to be altered in the earliest stages of the disease. All 136 individuals were mentally-normal, late-middle-aged Phoenix-area volunteers solicited from newspaper advertisements. They ranged in age from 47 to 68, with an average age of 55.

Scans showed that individuals without the KIBRA T-allele -- those with only KIBRA C-alleles from their mother and from their father -- had less metabolic brain activity when compared to those individuals carrying the T-allele -- from either their mother or father, or both. These differences were found in the precuneus and posterior cingulated regions of the brain affected in the earliest stages of Alzheimer's.

Previous work led by Reiman illustrated a similar finding when individuals were grouped according to whether they carried the mo
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. International experts collect alpine fungi in Beartooth Mountains of Montana
2. Corporate Safe Specialists Launches International Sales Efforts
3. International team reveals first prognosticator of survival in aggressive cancer
4. [video] Michael DePasquale, CEO of BIO-key International, Inc., Discusses Q2 2008 Revenue Growth on WallSt.nets 3-Minute Press Show
5. NYU Langone Medical Centers tip sheet to the International Conference on Alzheimers Disease 2008
6. International conference to release new findings on smell and taste
7. International team identifies 21 new genetic risk factors for Crohns disease
8. 2008 ASABE Annual International Meeting
9. The 12th International Behavioral Ecology Congress held at Cornell University, Aug. 10-14
10. Biotechnology key to developing sustainable industries says international panel
11. BBVA Foundation international study on attitudes to stem cell research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)... Calif. , Dec. 2, 2014   ... globally deployed, innovative test solutions for military, aerospace, ... newest version of its successful TS-900 PXI ... performance and features of high-end systems to customers ... outstanding value compared to traditional ATE. ...
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... York College, and one of the most prolific inventors ... that are transmitted from Smartphones to third party agencies. ... and has one of the earliest known patents in ... usage in the military, child care, elder care and ...
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... in microcontroller (MCU) and touch technology solutions, today launched ... sensors with the widest V cc range ... temperature accuracy and faster I 2 C bus communication ... serial EEPROM memory making them ideal for consumer, industrial, ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... Institute of Medical Biology (IMB) scientists under the Agency ... part of an international team of researchers [1]who became ... behind a rare skin cancer which grows rapidly for ... published in Nature Genetics [2] today. ...
... In parts of Indiaspecifically the less developed states of ... per capita is a harsh reality. People in this ... According to the U.S. Agency for International Development ... that reduces global hunger and poverty. That is why ...
... the mammalian eye convert light stimuli into electrical signals and ... which, in turn, forward them to the brain. The interneurons ... the individual ganglion cells receive visual information from a circular ... Some ganglion cells are only activated, for example, when light ...
Cached Biology News:Scientists discover cause of rare skin cancer that heals itself 2University of Illinois partners in $9.6 million grant to bolster food security in India 2New microscope decodes complex eye circuitry 2New microscope decodes complex eye circuitry 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... Additional tools for neuroscience researchers , , ... D. Browning, Mary Ellen Simcox ,Stratagene Cloning Systems, ... primer sets for the rat and human,NMDA receptor. ... in reverse,transcriptase-mediated polymerase chain reaction (RT-PCR) assays to ...
... CastAway system application , Iain Kilty ... 01304 618482 , Differential display PCR (DDPCR) ... differentially expressed between cell types. Application of,DDPCR ... for elucidating the,mechanisms involved in allergic responses. ...
... Epicurian Coli XL1-Red cells allow isolation ... T. Bornscheuer Markus M.,Enzelberger ,Institute ... Josef Altenbuchner ,Institute for Industrial Genetics, University of ... Organic Chemistry, University of Hannover, Hannover, Germany , ...
Cached Biology Technology:Gene-Specific Primers for NMDA Receptor Subunits 2Gene-Specific Primers for NMDA Receptor Subunits 3Gene-Specific Primers for NMDA Receptor Subunits 4Fractionating DNA Fragments Generated by Differential Display PCR 2Fractionating DNA Fragments Generated by Differential Display PCR 3Fractionating DNA Fragments Generated by Differential Display PCR 4Using XL1-Red Mutator Strain to Generate Esterase Variants 2Using XL1-Red Mutator Strain to Generate Esterase Variants 3Using XL1-Red Mutator Strain to Generate Esterase Variants 4Using XL1-Red Mutator Strain to Generate Esterase Variants 5
... Gene Pulser Xcell eukaryotic system, ... Hz, is used for electroporation ... includes the main unit, CE ... range) or square-wave pulses, ShockPod ...
Request Info...
... 96 and PowerPac basic power supply are used ... in agarose gels. This Model 96 cell includes ... UV-transparent gel tray with fluorescent ruler, and a ... and 220-240 V, provides output of 10-300 V, ...
... This CE-based system provides clear advantages ... (viral load, gene expression), mutation analysis, ... easy-to-use system with microplate connectivity is ... and quality control. The P/ACE ...
Biology Products: