Navigation Links
International TGen-led team finds link between brain protein and Alzheimer's disease
Date:9/15/2008

Neurogenomics Division and executive director of the Banner Alzheimer's Institute, said, "This study suggests a link between the inherited genes involved in normal human memory and the predisposition to Alzheimer's disease.

"It provides promising new targets at which to aim new treatments to stave off Alzheimer's and improve memory," said Reiman, who also is director of the Arizona Alzheimer's Consortium and a contributor to the study.

The findings announced today are built on a 2006 study led by collaborative teams from Arizona and Zurich, Switzerland, and published in the journal Science. That pioneering TGen research revealed a link between KIBRA and memory, in which healthy adults with the KIBRA T-allele performed better on memory tests than those without this gene.

In the most recent analysis, Huentelman's team confirmed a link between KIBRA and Alzheimer's in three different ways:

  • Using TGen's powerful analytic tools to find a genetic association between the KIBRA gene and Alzheimer's disease, comparing more than 1,700 living and deceased people, with and without the disorder.

  • Using gene expression tools to find that KIBRA, and genes for other molecules that interact with KIBRA, were significantly altered in the neurons of people who had Alzheimer's disease, but not in individuals without the disorder.

  • Using a brain imaging technique called positron emission tomography (PET) to find that cognitively-normal, late-middle-aged people lacking the protective T-allele gene had reduced activity in parts of the brain usually affected by Alzheimer's.

Genetic association study

In a study of 702 deceased persons diagnosed with Alzheimer's, and 1,026 living and deceased persons with and without Alzheimer's, researchers found that non-carriers of the KIBRA T-allele had increased risk of late-onset Alzheimers.

The genotyped samples came from fiv
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. International experts collect alpine fungi in Beartooth Mountains of Montana
2. Corporate Safe Specialists Launches International Sales Efforts
3. International team reveals first prognosticator of survival in aggressive cancer
4. [video] Michael DePasquale, CEO of BIO-key International, Inc., Discusses Q2 2008 Revenue Growth on WallSt.nets 3-Minute Press Show
5. NYU Langone Medical Centers tip sheet to the International Conference on Alzheimers Disease 2008
6. International conference to release new findings on smell and taste
7. International team identifies 21 new genetic risk factors for Crohns disease
8. 2008 ASABE Annual International Meeting
9. The 12th International Behavioral Ecology Congress held at Cornell University, Aug. 10-14
10. Biotechnology key to developing sustainable industries says international panel
11. BBVA Foundation international study on attitudes to stem cell research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the ... than at international borders. Over the past decade, ... allowed veteran travelers to self process through border ... Kiosks at an increasing number of airports, seaports, ... According to Maxine Most , Principal ...
(Date:12/11/2014)... 10, 2014  That blood pressure plays a role in ... – the medical term for high blood pressure – was ... the inflatable cuff that,s used in measuring blood pressure was ... nothing new about hypertension, its triggers and its effects. In ... condition and the best ways to treat it. ...
(Date:12/10/2014)... 2014  Wake Forest Baptist Medical Center today announced plans ... of Medicine. Funding for this $50 million capital project ... be publicly launched next summer. The ... 60 series R.J. Reynolds Tobacco Company complex, adjacent to ... immediately with plans to be ready to welcome medical ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... Graeme Ian Bell, PhD, the Louis Block Distinguished Service ... in the Kovler Diabetes Center at the University of ... for 2012 for his pioneering work in understanding the ... diabetes. The prize, the world,s largest award ...
... Mak Saito, a biogeochemist at Woods Hole Oceanographic Institution, has ... by the Gordon and Betty Moore Foundation. Saito is one ... funds from a total of up to $35 million over ... marine microbial ecology. "We are grateful to the Moore ...
... Wilmington, DE This month, Molecular Pharmaceutics ... for Childhood Cancer Research and the Materials Science ... about the potential for nanotechnology to deliver chemotherapeutic ... without harming healthy cells. To date, nanoparticle-based drug ...
Cached Biology News:University of Chicago's Graeme Bell receives international diabetes prize 2University of Chicago's Graeme Bell receives international diabetes prize 3WHOI scientist receives marine microbiology initiative investigator award from Moore Foundation 2Nanotechnology drug delivery shows promise for treatment of pediatric cancer 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... (Nasdaq: MATK ) announced today that it will ... Pharmaceuticals Conference in,London. The conference is being held May ... Steve Dubin, CEO will be presenting on Wednesday,May 28, ... Interested parties may access a live audio webcast ...
... the news release, "Rosetta Genomics Reports First Quarter 2008,Financial ... Rosetta Genomics Ltd,nasdaq:ROSG over PR Newswire, we are advised ... the conference call, as stated beneath the header,Conference Call ... ET,as previously issued. Complete, corrected release follows:, , ...
... YORK, May 21 Citing increasing demand for a ... Dr. Lance H. Brown has expanded his Manhattan practice ... His telephone number,there is 631-725-1771., As summer draws ... of too many seasons in the sun. Those seeking ...
Cached Biology Technology:/C O R R E C T I O N -- Rosetta Genomics Ltd/ 2/C O R R E C T I O N -- Rosetta Genomics Ltd/ 3/C O R R E C T I O N -- Rosetta Genomics Ltd/ 4/C O R R E C T I O N -- Rosetta Genomics Ltd/ 5/C O R R E C T I O N -- Rosetta Genomics Ltd/ 6/C O R R E C T I O N -- Rosetta Genomics Ltd/ 7/C O R R E C T I O N -- Rosetta Genomics Ltd/ 8/C O R R E C T I O N -- Rosetta Genomics Ltd/ 9/C O R R E C T I O N -- Rosetta Genomics Ltd/ 10/C O R R E C T I O N -- Rosetta Genomics Ltd/ 11/C O R R E C T I O N -- Rosetta Genomics Ltd/ 12/C O R R E C T I O N -- Rosetta Genomics Ltd/ 13/C O R R E C T I O N -- Rosetta Genomics Ltd/ 14/C O R R E C T I O N -- Rosetta Genomics Ltd/ 15/C O R R E C T I O N -- Rosetta Genomics Ltd/ 16/C O R R E C T I O N -- Rosetta Genomics Ltd/ 17/C O R R E C T I O N -- Rosetta Genomics Ltd/ 18/C O R R E C T I O N -- Rosetta Genomics Ltd/ 19/C O R R E C T I O N -- Rosetta Genomics Ltd/ 20Board Certified Dermatologist and President-Elect of the Dermatologic Society of Greater New York, Dr. Lance H. Brown Takes His Comprehensive Practice to East Hampton, NY 2
... (6-28) (human, bovine, porcine, rat) ... (VIP) receptor antagonist. This carboxy-terminal ... be twofold more potent than ... antagonists. Storage: ...
Protein 3D structure prediction, via threading. Easy to use....
L1 Protein of Human Papilloma Virus Purified Anti-Viral-transformed cells clone CAMVIR-1, Isotype Mouse IgG 2a , 0.1 mg Consult technical datasheet for details....
ANTI 5-HYDROXYTRYPTOPHAN CONJ....
Biology Products: