Navigation Links
International TGen-led team finds link between brain protein and Alzheimer's disease

Neurogenomics Division and executive director of the Banner Alzheimer's Institute, said, "This study suggests a link between the inherited genes involved in normal human memory and the predisposition to Alzheimer's disease.

"It provides promising new targets at which to aim new treatments to stave off Alzheimer's and improve memory," said Reiman, who also is director of the Arizona Alzheimer's Consortium and a contributor to the study.

The findings announced today are built on a 2006 study led by collaborative teams from Arizona and Zurich, Switzerland, and published in the journal Science. That pioneering TGen research revealed a link between KIBRA and memory, in which healthy adults with the KIBRA T-allele performed better on memory tests than those without this gene.

In the most recent analysis, Huentelman's team confirmed a link between KIBRA and Alzheimer's in three different ways:

  • Using TGen's powerful analytic tools to find a genetic association between the KIBRA gene and Alzheimer's disease, comparing more than 1,700 living and deceased people, with and without the disorder.

  • Using gene expression tools to find that KIBRA, and genes for other molecules that interact with KIBRA, were significantly altered in the neurons of people who had Alzheimer's disease, but not in individuals without the disorder.

  • Using a brain imaging technique called positron emission tomography (PET) to find that cognitively-normal, late-middle-aged people lacking the protective T-allele gene had reduced activity in parts of the brain usually affected by Alzheimer's.

Genetic association study

In a study of 702 deceased persons diagnosed with Alzheimer's, and 1,026 living and deceased persons with and without Alzheimer's, researchers found that non-carriers of the KIBRA T-allele had increased risk of late-onset Alzheimers.

The genotyped samples came from fiv

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Page: 1 2 3 4

Related biology news :

1. International experts collect alpine fungi in Beartooth Mountains of Montana
2. Corporate Safe Specialists Launches International Sales Efforts
3. International team reveals first prognosticator of survival in aggressive cancer
4. [video] Michael DePasquale, CEO of BIO-key International, Inc., Discusses Q2 2008 Revenue Growth on WallSt.nets 3-Minute Press Show
5. NYU Langone Medical Centers tip sheet to the International Conference on Alzheimers Disease 2008
6. International conference to release new findings on smell and taste
7. International team identifies 21 new genetic risk factors for Crohns disease
8. 2008 ASABE Annual International Meeting
9. The 12th International Behavioral Ecology Congress held at Cornell University, Aug. 10-14
10. Biotechnology key to developing sustainable industries says international panel
11. BBVA Foundation international study on attitudes to stem cell research
Post Your Comments:
(Date:10/7/2015)... Sweden , October 8, 2015 ... the revenues for Fingerprint Cards (FPC) during third quarter 2015 ... revenue guidance of around 860 MSEK that was communicated 20 ... Considering a further strengthened delivery capacity and a continued growing ... quarter 2015 is estimated to be higher than during the ...
(Date:10/6/2015)... LAKE CITY , Oct. 6, 2015 ... company, announced today that it has signed a contract ... monitoring services across the full range of sentences under ... Group,s President of the Americas. "This contract with the ... region of the US and advances our position as ...
(Date:10/5/2015)... ) releases the following ... NXTD ), a biometric authentication company focused on the ... ) releases the following market and company update ... authentication company focused on the growing mobile commerce market. ... ) releases the following market and company update ...
Breaking Biology News(10 mins):
... the most commonly cultivated cacao plant in the world ... this week. Researchers have utilised high quality DNA sequences to ... markers that can lead to higher yielding cocoa plants that still ... the cacao tree ( Theobroma cacao L. ...
... species, according to a new study led by Woods ... published in the journal PLOS ONE . Because ... may have far-reaching effects on the ocean environment and ... the center of the ocean ecosystemnearly all animals are ...
... insecurity increases the risk of death among injection drug ... life-prolonging antiretroviral therapy (ART), according to a new study ... the peer-reviewed science journal, PLoS One , examines ... among injection drug users. Food insecurity is defined by ...
Cached Biology News:
(Date:10/9/2015)... Oct. 9, 2015  Pulmatrix, Inc., (NASDAQ: PULM ) ... investor conferences. th Annual BIO Investor ... (2:00 pm EDT). --> th Annual ... am PDT (2:00 pm EDT). --> Pulmatrix ... Growth Stock Conference on Thursday, October 15, 2015 at 8:30 ...
(Date:10/9/2015)... ... October 09, 2015 , ... Leading microbial genomics startup uBiome today ... understand the relationship between weight management and the microbiome. The study uses the ResearchKit ... using an iPhone app. , The uBiome app is available as a free download ...
(Date:10/8/2015)... Fla. , Oct. 8, 2015   Intrexon ... synthetic biology, today announced the appointment of Joseph ... Environment Sector, succeeding Nir Nimrodi who continues ... Vaillancourt will direct Intrexon,s endeavors to generate sustainable, biologically ... America , where he held a variety of ...
(Date:10/8/2015)... , Oct. 8, 2015  Genetic testing for mutations ... the identification of more couples at risk of having ... presented today at the 2015 American Society of Human ... in Baltimore, Maryland . The study ... (NYSE: DGX ) are presenting at the conference ...
Breaking Biology Technology:
... (a subsidiary of Elan Corporation, plc) ( ELN) ("Elan") to acquire the analgesic therapy, PRIALT(R) (ziconotide intrathecal infusion). , ... , , ... ... ...
... ... Be Discussed and Demonstrated at Philadelphia Conference , ... Chicago, IL (PRWEB) March 11, 2010 -- ClearTrial, the ... panel discussion which includes pharmaceutical analysts from Deutsche Bank and Cowen & Company at ...
... TORONTO , March 11 /PRNewswire/ - Trillium Therapeutics ... announced that it has entered into two definitive license agreements ... Children (SickKids) in Toronto, Ontario , granting Trillium exclusive ... of hematopoietic stem cell transplantation and cancer. , ...
Cached Biology Technology:
... Software reads and processes raw ... microarray data for analysis. ... one 2-year license for Feature ... , * one CD-ROM ...
... imported for data analysis , Automatic grid, subgrid ... template assignment , ... Extensive background and signal options to optimize, ... results , ...
... DNA Gel Stain combo offers these benefits: ... products separately Offers a ... Eliminates risks to yourself, the environment ... from 100 bp to >30 kb. UltraPure Agarose is ...
... stocks contained in standard 96-well microtiter plates. ... approximately 5,000 clones per plate. After positive ... the corresponding subplate is screened with a ... well(s). Cells from a positive well are ...
Biology Products: