Navigation Links
International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
Date:5/31/2009

ely than non-carriers to develop DILI in response to this antibiotic. This risk-associated variant is relatively common in Europe, but less prevalent in Africa and East Asia. In addition to HLA-B*5701, variations on chromosome 3 were also found to influence the risk for DILI. These findings provide initial insights into the mechanism of DILI and may have the potential to help identify individuals who have an increased risk for flucloxacillin related liver injury. Despite being at substantially higher risk than non-carriers, only a small proportion of carriers actually develop liver problems in response to flucloxacillin. Thus, further analysis and research will be needed to determine whether a clinically useful biomarker test could be developed for this susceptibility.

The paper can be found on both the Nature Genetics (http://www.nature.com/ng/index.htm) and the SAEC's (www.saeconsortium.org) websites. Qualified researchers, who enter into a data use agreement, can obtain free access via the SAEC's website to the supporting study data, for use exclusively in biomedical research.

"We are pleased to be able to provide these initial results to the research community, to both improve the productivity of drug development and to begin the critical process of developing validated biomarkers to forecast patients who may be at risk for DILI," said Arthur Holden, founder and chairman of the SAEC. "To date, in conjunction with our collaborators, we have assembled one of the largest DILI research collections in the world. We expect additional important DILI genetic findings to emerge from these research efforts over the next 12-18 months."

"Our aim is to ensure that commonly prescribed drugs can be used more safely. This is an important step in developing a test that can be used prior to prescribing flucloxacillin. We look forward to m
'/>"/>

Contact: Arthur Holden
aholden@earthlink.net
773-867-8595
International Serious Adverse Events Consortium
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. World-class innovation through international cooperation
2. International team tracks clues to HIV
3. SRI International to screen drugs that fight 2009 H1N1 influenza A
4. SRI International receives $100,000 Grand Challenges Explorations grant
5. International team finds key gene that allows plants to survive drought
6. BIO-key(R) International Showcasing Biometric Identification Technology at 2009 RSA Conference
7. Canadian biomedical engineering pioneer receives international award
8. Major international study challenges notions of how genes are controlled in mammals
9. International honor for University of East Anglia ocean researcher
10. Biomedical researchers invited to design experiments for the International Space Station
11. International climate change researchers meet, review latest findings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... 7, 2015  Based on its recent analysis ... recognizes Credence ID, LLC with the 2015 Asia-Pacific ... the Year Award. Credence ID has developed a ... mission of offering enrollment and identification solutions to ... ID was formed by experts from the mobile ...
(Date:7/2/2015)... 2015 Fingerprint Cards has received an ... FPC1155 from the distributor World Peace Industrial Group (WPI), part ... Asia . Deliveries are planned to take ... used by smartphone manufacturers in Asia . ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
(Date:6/26/2015)... -- ATL Technology, LLC, a top provider of electromechanical contract ... solutions, headquartered in Springville, Utah , has ... corporation with locations in Santa Clara, ... ). This acquisition will incorporate MedConx,s manufacturing ... Technology,s existing facility in Costa Rica , ...
Breaking Biology News(10 mins):Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2
... life sciences journal F1000Research is that ... the article. Openly sharing data is an important step in ... published research, as well as enabling data reuse. ... the data in the journal,s articles to be assessed and ...
... balanced interplay of four molecules that trigger and govern ... an important basic science discovery, it helps explain why ... genes cannot fight infection effectively, and develop rare and ... of a number of different types of cells that ...
... poison-dart frog, a red male isn,t much brighter than a green ... the green and red variants of the same species of frog ... Ecology and Sociobiology , led by Beatriz Willink of the Universidad ... The bright colors of poison-dart frogs serve not only ...
Cached Biology News:F1000Research launch data plotting tool 2Molecular interplay explains many immunodeficiencies 2Green poison-dart frog varies mating call to suit situation 2
(Date:7/30/2015)... TX, USA (PRWEB) , ... July 30, 2015 ... ... and microsystems, has appointed Francois Vieillard as Sales & Marketing Director. , ... positions, Francois Vieillard will be responsible for reinforcing Tronics’ business development activities worldwide. ...
(Date:7/30/2015)... , ... July 30, 2015 , ... The 2015 Market ... study on the current state of the global Propanol market with a focus on ... BASF, Eastman, Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG ...
(Date:7/30/2015)... VANCOUVER, Washington , July 30, 2015 ... "Biosimulation Market, by Product (Software, Molecular Modeling, PB/PK, PKPD, ... (Drug Discovery & Development, Preclinical, Clinical Trial), by End ... the Biosimulation Market is expected to reach USD 2,107.99 ... at a CAGR of 15.29%. Browse ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... field clinical study of its canine osteoarthritis stem cell product, currently under development ... City, KS) and will be marketed in the US by Aratana. This product, ...
Breaking Biology Technology:Tronics appoints Francois Vieillard as Sales and Marketing Director 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3
... 2008 Martek,Biosciences Corporation announced today that the ... has entered a Final Judgment and Order,of Dismissal ... on behalf of certain purchasers of Martek common ... securities laws and arose out of,allegations, among other ...
... April 7, 2008 Microbia, Inc. today,announced that ... Inc.,The ironwood is a long-lived tree that thrives ... as long as 1,500 years. Known as a,"nurse ... temperatures,higher water availability, and more organic matter for ...
... advance collaborative research worldwide, HUNTSVILLE, Ala., ... today that leading research institutions, the Institute ... University of,Queensland, and the Biotech Research and ... Copenhagen have recently purchased access to Open,Biosystems ...
Cached Biology Technology:Martek Announces Final Judgment and Order of Dismissal in Class Action 2Microbia Announces Name Change to Ironwood Pharmaceuticals 2Open Biosystems' Open Access RNAi Program Adopted by University of Copenhagen and University of Queensland 2Open Biosystems' Open Access RNAi Program Adopted by University of Copenhagen and University of Queensland 3
Ultra Pure Grade. Used in conjunction with IPTG to identify bacterial colonies that contain recombinant plasmids by blue/white selection. X-Gal forms an intense blue precipitate in the presence of be...
Request Info...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to KLH (Keyhole Limpet Hemocyanin) lysine through amide bonds....
Estrogen Receptor (ER) Competitor Assay Kits Green for Estrogen Receptors-alpha and -beta (ER-Alpha and ER-Beta) are ideal for screening novel estrogen receptor binding compounds and endocrine disrup...
Biology Products: