Navigation Links
International Rett Syndrome Foundation awards $2M for cutting-edge Rett syndrome research
Date:10/1/2009

mine the impact of MeCP2 loss of function by selectively knocking-out MeCP2 function in a specific population of neurons followed by rescue of function in the same discreet populations of neurons. In Rett syndrome, the catecholaminergic system may have a disproportionate impact on the development of disease. These experiments are therefore very relevant to understanding the neurological underpinnings of the disease. In addition, given the recent reversal experiments, it is clear that MeCP2 levels within cells must be carefully regulated to avoid harmful consequences of over-expression or under-expression. The expected beneficial effects of restoring MeCP2 function in specific cell populations is of great importance for this reason and could highlight new treatment strategies for Rett syndrome.

Paul H. Patterson PhD, California Institute of Technology
Regulation of MeCP2-mediated gene expression by IkB kinase alpha

MeCP2 biology is complicated because MeCP2 has been described as both a repressor and as an activator of gene expression. Maintaining critical levels of MeCP2 appears to be required for normal brain function. However, the molecules regulating MeCP2 expression itself are poorly understood. This grant proposes to test whether a cellular signaling molecule (IKKα), is involved in regulation of MeCP2 function. IKKα is responsive to a wide range of stimuli and is implicated in other neurological diseases. Thus, understanding the link between IKKα and MeCP2 may prove to be crucial for understanding Rett syndrome neuropathology and provide a link to other neurodevelopmental disorders. Future directions include identifying other MeCP2-regulated targets that are controlled by IKKα, which will likely reveal new drug target molecules and signaling pathways related to Rett syndrome. This is a novel proposal that seeks to understand the relevance of a signaling pathway that may be controlling the activity of MeC
'/>"/>

Contact: Dr. Antony Horton
212-459-2608
International Rett Syndrome Foundation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. International conference on endothelin
2. International event brings worlds top cancer doctors to Queens
3. Forest Service to host 2nd International Conference on Forests and Water in a Changing Environment
4. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
5. International conference on CO2 sequestration processes
6. International research team seeks to unravel flatworm regeneration
7. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
8. Journal of Vascular and Interventional Radiology increases impact, international reach
9. International team of students and scientists on month-long field course in Siberian Arctic
10. ESHRE launches international study of polar body screening
11. International collaboration by scientists culminates in novel ion channels database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2015)... 23, 2015 Research and Markets ( ... "Global Outlook of the Biometrics Industry 2015 ... The global biometrics market is likely to ... applications owing to the uptake of multiple technologies ... that enhances the growth of biometrics in existing ...
(Date:7/13/2015)... JOSE, Calif. , July 13, 2015 /PRNewswire/ ... leading developer of human interface solutions, today announced ... generation touch and display driver integration (TDDI) product ... is the first to combine Synaptics , ... with proven display driver technology developed in the ...
(Date:7/9/2015)... , July 9, 2015  Synaptics Inc. ... of human interface solutions, today announced a ... first fully hardware encapsulated fingerprint sensor and ... technology is literally off the grid, isolating ... matching within the fingerprint sensor to provide ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... attention. But a study led by McGill researcher Sarah Kimmins ... equally important role in the health of their offspring. It ... diets and of food insecurity. The research focused on ... range of green leafy vegetables, cereals, fruit and meats. It ...
... SAN FRANCISCO, Calif. , Dec. 10, 2013 ... today announced preliminary results of an ongoing multi-center ... (mAb), which the company is developing as a ... disease or who were unfit for chemotherapy have ...
... Whitesides, Ph.D., and David Edwards, Ph.D., have been named ... joining 141 other innovators elected this year. ... to academic inventors who have demonstrated a prolific spirit ... tangible impact on quality of life, economic development, and ...
Cached Biology News:You are what your father eats 2KaloBios Announces Preliminary Phase 1 Results in Advanced Hematologic Malignancies with KB004, an Anti-EphA3 Monoclonal Antibody 2KaloBios Announces Preliminary Phase 1 Results in Advanced Hematologic Malignancies with KB004, an Anti-EphA3 Monoclonal Antibody 3KaloBios Announces Preliminary Phase 1 Results in Advanced Hematologic Malignancies with KB004, an Anti-EphA3 Monoclonal Antibody 4KaloBios Announces Preliminary Phase 1 Results in Advanced Hematologic Malignancies with KB004, an Anti-EphA3 Monoclonal Antibody 5Wyss Institute at Harvard University announces election of 2 faculty to Natl Academy of Inventors 2Wyss Institute at Harvard University announces election of 2 faculty to Natl Academy of Inventors 3
(Date:7/29/2015)... DUBLIN , July 29, 2015 ... ) has announced the addition of the ... to their offering. The Global Biosimilars ... study of the rapidly growing biosimilars market. With ... industry striving to minimize costs, biosimilars are being ...
(Date:7/29/2015)... DIEGO , July 29, 2015  Pfenex Inc. ... 2015 financial results will be released on Thursday, August ... am Eastern Time, Pfenex management will host a conference ... business update.  A press release outlining the financial results ... the call. Please call 1-866-376-8058 (US) or ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - Aeterna Zentaris ... announced it has selected an optimized Erk inhibitor ... in the development of a new class of ... pathway represents a prime target for therapeutic intervention ... activities and survival benefits for B-Raf and Mek ...
(Date:7/29/2015)... Houston, TX (PRWEB) , ... July 29, 2015 , ... ... new levee system to protect the Orange County, Texas area from future ... the multi-firm design team in determining several potential levee alignment alternatives for providing protection, ...
Breaking Biology Technology:Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3Preventing Storm Surge Flooding in Houston 2
... Highlights Trends In eCTD Migration And Submissions Outsourcing And, Provides ... ... America And Europe, PHILADELPHIA and LONDON, July 17 ... its 2008,Liquent Regulatory Affairs Trends Survey. The survey attracted respondents,from across ...
... Johnson & Johnson Pharmaceutical,Research & Development, L.L.C. ... (FDA) Anti-Infective Drugs Advisory Committee voted in,favor of ... for,injection) for the treatment of hospital-acquired pneumonia, or ... committee voted that 500 mg of DORIBAX at ...
... BioMarin,Pharmaceutical Inc. (Nasdaq and SWX: BMRN) announced today ... Sankyo), has received marketing,approval from the Japanese Ministry ... extension of Biopten(R) (sapropterin dihydrochloride), which,contains the same ... the,treatment of patients with phenylketonuria (PKU). BioMarin will ...
Cached Biology Technology:The Scientific Business of Thomson Reuters Publishes Its 2008 Liquent Regulatory Affairs Trends Survey Results 2The Scientific Business of Thomson Reuters Publishes Its 2008 Liquent Regulatory Affairs Trends Survey Results 3FDA Advisory Committee Provides Opinion of DORIBAX(TM) for the Treatment of Hospital-Acquired Pneumonia 2FDA Advisory Committee Provides Opinion of DORIBAX(TM) for the Treatment of Hospital-Acquired Pneumonia 3FDA Advisory Committee Provides Opinion of DORIBAX(TM) for the Treatment of Hospital-Acquired Pneumonia 4Biopten (Sapropterin Dihydrochloride) Approved by Japanese Ministry of Health for the Treatment of PKU 2Biopten (Sapropterin Dihydrochloride) Approved by Japanese Ministry of Health for the Treatment of PKU 3Biopten (Sapropterin Dihydrochloride) Approved by Japanese Ministry of Health for the Treatment of PKU 4
... is designed for imaging of chemiluminescent, fluorescent ... offer direct control for users who wish ... hand , A range of high resolution, ... all fluorescent and chemiluminescent applications , ...
... SM22 alpha, also known as smooth muscle ... at high levels in various tissues such as ... with the regulatory protein, calponin. SM22 alpha expression ... smooth muscle in both vascular and visceral forms. ...
... system is designed for multiple user laboratories ... for TLC applications. The MultiDoc-It is available ... enclosure provides a darkroom environment and protects ... Use image capture and enhancement , ...
PC based system for superior chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
Biology Products: