Navigation Links
International Rett Syndrome Foundation awards $2M for cutting-edge Rett syndrome research
Date:10/1/2009

mine the impact of MeCP2 loss of function by selectively knocking-out MeCP2 function in a specific population of neurons followed by rescue of function in the same discreet populations of neurons. In Rett syndrome, the catecholaminergic system may have a disproportionate impact on the development of disease. These experiments are therefore very relevant to understanding the neurological underpinnings of the disease. In addition, given the recent reversal experiments, it is clear that MeCP2 levels within cells must be carefully regulated to avoid harmful consequences of over-expression or under-expression. The expected beneficial effects of restoring MeCP2 function in specific cell populations is of great importance for this reason and could highlight new treatment strategies for Rett syndrome.

Paul H. Patterson PhD, California Institute of Technology
Regulation of MeCP2-mediated gene expression by IkB kinase alpha

MeCP2 biology is complicated because MeCP2 has been described as both a repressor and as an activator of gene expression. Maintaining critical levels of MeCP2 appears to be required for normal brain function. However, the molecules regulating MeCP2 expression itself are poorly understood. This grant proposes to test whether a cellular signaling molecule (IKKα), is involved in regulation of MeCP2 function. IKKα is responsive to a wide range of stimuli and is implicated in other neurological diseases. Thus, understanding the link between IKKα and MeCP2 may prove to be crucial for understanding Rett syndrome neuropathology and provide a link to other neurodevelopmental disorders. Future directions include identifying other MeCP2-regulated targets that are controlled by IKKα, which will likely reveal new drug target molecules and signaling pathways related to Rett syndrome. This is a novel proposal that seeks to understand the relevance of a signaling pathway that may be controlling the activity of MeC
'/>"/>

Contact: Dr. Antony Horton
212-459-2608
International Rett Syndrome Foundation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. International conference on endothelin
2. International event brings worlds top cancer doctors to Queens
3. Forest Service to host 2nd International Conference on Forests and Water in a Changing Environment
4. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
5. International conference on CO2 sequestration processes
6. International research team seeks to unravel flatworm regeneration
7. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
8. Journal of Vascular and Interventional Radiology increases impact, international reach
9. International team of students and scientists on month-long field course in Siberian Arctic
10. ESHRE launches international study of polar body screening
11. International collaboration by scientists culminates in novel ion channels database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... affect the connections between nerve cells and influence the ... of the brain that plays a significant role in ... of the study have been published in the journal ... active communication between nerve cells, known as neurons. For ... network where they constantly relay signals to one another. ...
(Date:7/24/2014)... hazard in the United States, wildland managers often utilize ... suppressed trees (ladder fuels). These cuttings and other ... fire danger in order to dispose of the material. ... managers often cover all or part of the debris ... agricultural plastic, in order to keep water out. A ...
(Date:7/24/2014)... currently conducting research into the potato genes that best ... a reduction in rainfall and increased extremes of hot ... resistant genes in order to create new potato varieties ... is also seeking to find out how the current ... drought and higher and lower temperatures. , This research ...
Breaking Biology News(10 mins):A protein couple controls flow of information into the brain's memory center 2A protein couple controls flow of information into the brain's memory center 3A protein couple controls flow of information into the brain's memory center 4Study gives new perspective on agricultural plastic, debris burning, and air quality 2Neiker-Tecnalia is researching the potato genes that best adapt to climate change 2
... A University of Sheffield academic is helping a team ... European genetic heritage. Citizen Scientists are not required ... they possess a passion for the subject and are ... involved in research. Dr Andy Grierson, from the ...
... Researchers could have a new method to rebuild wetlands ... monitoring severe flooding of the Mississippi River. A team ... in collaboration with the U.S. Army Corps of Engineers, published ... In the spring and summer of 2011, high floodwaters on ...
... While some published research has hinted at the connection ... among young, athletic African-American males, which was initially observed ... study with the first sizeable patient series definitively confirms ... The sickle cell trait, for which all U.S. African ...
Cached Biology News:Citizen science helps unlock European genetic heritage 2Citizen science helps unlock European genetic heritage 3Spillways can divert sand from river to rebuild wetlands 2Sickle cell trait can cause sudden cardiac death in black athletes: Why is this controversial? 2Sickle cell trait can cause sudden cardiac death in black athletes: Why is this controversial? 3
(Date:7/24/2014)... 2014  CorMedix Inc. (NYSE MKT: CRMD), a ... products for the prevention and treatment of cardiorenal ... on July 18, 2014 from the NYSE MKT ... CorMedix plan to regain compliance with continued listing ... NYSE-MKT is continuing the Company,s listing and has ...
(Date:7/24/2014)... 1000 balances – 4 steps – One Recommendation: the ... expertly narrows down the mass of product choices to ... , First, select the working environment, then enter ... and define the accuracy – it’s really that simple. ... list to models that fit best with the customer’s ...
(Date:7/24/2014)... Brook, NJ (PRWEB) July 24, 2014 ... to manage numerous projects in the MENA region during ... to have a preferred provider agreement with DZS to ... the MENA region,” said Global VP of R&D and ... "DZS has developed excellent operational practices with a focus ...
(Date:7/23/2014)... in saving China,s endangered national treasure, the giant panda. ... reserves that have been established and three large breeding ... in the wild. , Breeding programs in conservation ... improving genetic diversity, avoid inbreeding and ultimately, introduce pandas ... programs doing so far? , In a new study ...
Breaking Biology Technology:CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3SBI Pharmaceuticals Co. Ltd. Enters into Preferred Provider Agreement with DZS Clinical Services 2
... VRUS ) management will present at the Third Annual ... 2008 at the Le,Parker Meridien in New York City. ... of the company on Monday,October 6, 2008, from 10:00-10:30 ... Mr. Price,s overview via the internet, log,on to the ...
... DUBLIN, Ireland, October 1 Shire Limited,(LSE: SHP, NASDAQ: ... approval by shareholders at the Annual General,Meeting on September ... Shire,plc with effect from today., Shire plc,s ticker ... ISIN numbers of the Company,s Ordinary shares and American ...
... confirms implementation of quality systems in product ... ... function assay, COLUMBIA, Md., Oct. 1 Cylex ... The 13485:2003 certification,includes compliance with the Canadian Medical Devices ...
Cached Biology Technology:Pharmasset to Present at the JMP Securities Healthcare Focus Conference on Monday, October 6th 2Cylex(TM) Receives ISO 13485:2003 and 9001:2000 Quality Certifications 2
... • Heat activated ,• Eliminates ... temperature ,• Excellent specificity allows extension ... secondary structures ,• Leaves an 'A' ... modified form of GeneChoice DNA Polymerase ...
NAK/TBK1 (CT) Affinity Purified Polyclonal Antibody...
... The Finnpipette BioControl ... innovative features as the ... universal handle fits allseven ... channel tip cone modules. ...
...
Biology Products: