Navigation Links
Intermountain study finds length of DNA strands can predict life expectancy
Date:3/9/2013

SAN FRANCISCO Can the length of strands of DNA in patients with heart disease predict their life expectancy?

Researchers from the Intermountain Heart Institute at Intermountain Medical Center in Salt Lake City, who studied the DNA of more that 3,500 patients with heart disease, say yes it can.

In the new study, presented Saturday, March 9, at the American College of Cardiology's Annual Scientific Session in San Francisco, the researchers were able to predict survival rates among patients with heart disease based on the length of strands of DNA found on the ends of chromosomes known as telomeresthe longer the patient's telomeres, the greater the chance of living a longer life.

The study is one of 17 studies from the Intermountain Heart Institute at Intermountain Medical Center that are being presented at the scientific session, which is being attended by thousands of cardiologists and heart experts from around the world.

Previous research has shown that telomere length can be used as a measure of age, but these expanded findings suggest that telomere length may also predict the life expectancy of patients with heart disease.

Telomeres protect the ends of chromosome from becoming damaged. As people get older, their telomeres get shorter until the cell is no longer able to divide. Shortened telomeres are associated with age-related diseases such as heart disease or cancer, as well as exposure to oxidative damage from stress, smoking, air pollution, or conditions that accelerate biologic aging.

"Chromosomes by their nature get shorter as we get older," said John Carlquist, PhD, director of the Intermountain Heart Institute Genetics Lab. "Once they become too short, they no longer function properly, signaling the end of life for the cell. And when cells reach this stage, the patient's risk for age-associated diseases increases dramatically."

Dr. Carlquist and his colleagues from the Intermountain Heart Institute at Intermountain Medical Center tested the DNA samples from more than 3,500 heart attack and stroke patients.

"Our research shows that if we statistically adjust for age, patients with longer telomeres live longer, suggesting that telomere length is more than just a measure of age, but may also indicate the probability for survival. Longer telomere length directly correlate with the likelihood for a longer lifeeven for patients with heart disease," said Dr. Carlquist.

Dr. Carlquist and his colleagues from the Intermountain Heart Institute at Intermountain Medical Center drew on two unique resources that offer unparalleled opportunity for researchers to study the effects of telomere length and survival rates of heart patients:

  • An archive of peripheral blood DNA samples collected from almost 30,000 heart patients, with as much as 20 years of follow-up clinical and survival data. This is stored in Intermountain Healthcare's world-renowned computerized medical informatics record system.

"With so many samples and very complete electronic records, it's a unique resource," said Dr. Carlquist. "It's unmatched in the world, and it allows us to measure the rate of change in the length of a patient's telomeres over time rather than just a snapshot in time, which is typical for most studies."

  • The opportunity to work with experts from around the world, including Richard Cawthon, MD, PhD, who's an international expert on telomere measurement and function.

"I believe telomere length could be used in the future as a way to measure the effectiveness of heart care treatment," said Dr. Carlquist. "We can already test cholesterol and blood pressure of a patient to see how treatment is working, but this could give us a deeper view into how the treatment is affecting the body and whether or not the treatment is working."


'/>"/>

Contact: Jess C. Gomez
jess.gomez@imail.org
801-718-8495
Intermountain Medical Center
Source:Eurekalert

Related biology news :

1. NYBG press publishes final volume of landmark Intermountain Flora series
2. Genetic study of house dust mites demonstrates reversible evolution
3. Bats not bothered by forest fires, study finds
4. International study: Excess dietary salt may drive the development of autoimmune diseases
5. Study pinpoints, prevents stress-induced drug relapse in rats
6. Assembling the transcriptome of a noxious weed: New resources for studying how plants invade
7. Study uncovers enzymes double life, critical role in cancer blood supply
8. Study maps human metabolism in health and disease
9. Volcanic aerosols, not pollutants, tamped down recent Earth warming, says CU-Boulder study
10. Study provides insights into plant evolution
11. New study reveals how sensitive US East Coast regions may be to ocean acidification
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... ... systems are increasingly being developed with Wi-Fi connectivity to reduce the amount of ... room to room. In addition, compact mobile devices including infusion pumps, heart and ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... unlimited source of human cardiovascular cells for research and the development of ... it possible to generate large numbers of cardiomyocytes (hPSC-CMs). Due to varying ...
(Date:5/23/2017)... PARK, CA (PRWEB) , ... May 23, 2017 , ... ... the publication of “Label-free isolation of prostate circulating tumor cells using Vortex microfluidic ... is the result of a collaboration with Dr. Dino Di Carlo and Dr. Matthew ...
(Date:5/23/2017)... ... May 23, 2017 , ... Cambridge Semantics , the leading ... year’s Bio-IT World Conference and Expo in Boston May 23-25 with a ... The Anzo Smart Data Lake is also a finalist for the Best of ...
Breaking Biology Technology: