Navigation Links
Interleukin-10 aids survival of cells transplanted to repair cardiac tissues after MI
Date:7/18/2014

Putnam Valley, NY. (July 18th 2014) The long-term, positive benefits of transplanted allogenic (other-donated) smooth muscle cells (SMCs) to repair cardiac tissues after myocardial infarction (MI) have been enhanced by the addition of interleukin 10 (IL-10) to the transplanted cells, report researchers in Canada. Their study with rats modeled with MI has shown that SMCs modified with IL-10 - a small, anti-inflammatory protein - benefitted cell survival, improved heart function, and also provided protection against the host's rejection of the allogenic SMCs.

The study will be published in a future issue of Cell Transplantation and is currently freely available on-line as an unedited early e-pub at: http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-CT1170Dhingra.

Three groups of rats modeled with MI were treated with SMC injections into the MI-damaged area of the heart. One group received unmodified autologous (self-donated) SMCs; a second group received unmodified allogenic (other-donated) SMCs; the third group received allogenic SMCs modified with IL-10. After three weeks, the unmodified autologous cells had engrafted while the unmodified allogenic cells had been rejected by the hosts. However, the IL-10-modified allogenic cells were found to greatly improve cell survival, improve ventricular function, increase myocardial wall thickness, and also prevent host immune response and rejection of the foreign cells.

"While the most appropriate cell type for cardiac repair remains controversial, mesenchymal stem cells (MSCs) that have been differentiated toward myogenic cells restore ventricular function better, as previous studies have shown," said study co-author Ren-Ke Li of the MaRS Centre in Toronto, Canada. "This study demonstrated that IL-10 gene-enhanced cell therapy prevented immune response, increased survival of SMCs in the heart, and improved cardiac function when compared to the results with the control groups."

The researchers noted that while the use of autologous SMCs donated by patients may be optimal for cell therapy, SMCs self-donated by older, debilitated patients who likely have other serious health problems, have limited regenerative capability. Thus, allogenic SMCs from young, healthy donors are the most beneficial cells, but rejection of foreign cells by the host has been a problem in allogenic cell transplantation. This study suggests that the use of allogenic SMCs modified with IL-10 can prevent host rejection.

"Future studies will be required to determine the long-term effects of IL-10 transduced SMCs to evaluate cell survival and cardiac function at six months and one year," concluded the researchers.

"The use of IL-10 overexpression to reduce rejection of allogenic SMCs is an interesting idea" said Dr. Amit N. Patel, director of cardiovascular regenerative medicine at the University of Utah and section editor for Cell Transplantation. "Further studies will help to determine if this manipulation could prove useful for translation of allogenic SMC therapies to humans".


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Sunshine vitamin ups bowel cancer survival odds, study finds
2. For corals adapting to climate change, its survival of the fattest -- and most flexible
3. Dental pulp stem cells promote the survival and regeneration of retinal cells after injury
4. Summertime cholesterol consumption key for wintertime survival for Siberian hamsters
5. Race could be a factor in head and neck cancer survival rates, MU researchers find
6. Gene therapy extends survival in an animal model of spinal muscular atrophy
7. Dam removal improves shad spawning grounds, may boost survival rate
8. A tale of survival
9. Henry Ford researchers identify genetic factors that may aid survival from brain cancer
10. Study finds long-term survival of human neural stem cells transplanted into primate brain
11. Lack of breeding threatens blue-footed boobies survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/21/2016)... March 22, 2016 Unique ... passcodes for superior security   ... provider of secure digital communications services, today announced it ... and offer enterprise customers, particularly those in the Financial ... and voice authentication within a mobile app, alongside, and ...
(Date:3/14/2016)... 2016 NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ... March 21 st .  The commercials will air on Bloomberg ... on the Street show. --> NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ...
(Date:3/10/2016)...   Unisys Corporation (NYSE: UIS ) today ... is testing its biometric identity solution at the Otay Mesa ... help identify certain non-U.S. citizens leaving the country. ... help determine the efficiency and accuracy of using biometric technologies ... run until May 2016. --> the United ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... ... April 28, 2016 , ... As part of an ... experts, and expanding its LATAM network and logistics capabilities. Enhancements have been ... their clinical trial projects. , The expansion will provide unmatched clinical trial logistics ...
(Date:4/27/2016)... ... April 27, 2016 , ... ... mobile devices with fingerprint recognition for secure access, voice recognition for hands-free communication, ... ways consumers are interacting with biometrics technology today. But if they asked ...
(Date:4/27/2016)... ... April 27, 2016 , ... PathSensors, Inc., a leading ... Dr. Lamka will assist PathSensors in expanding the use of the company‚Äôs CANARY® ... CANARY® test platform for the detection of harmful pathogens, including a number of ...
(Date:4/27/2016)... April 27, 2016 ReportsnReports.com ... with specific focus on US, EU, ... , to the healthcare business intelligence collection of ... Complete report on the Flow Cytometry market ... supported with 282 tables and figures is now ...
Breaking Biology Technology: