Navigation Links
Interfering with a double-edged sword: novel anti-inflammatory functions for interferons
Date:9/15/2010

Animals react to infections in a number of ways. Among the first is the production of cell factors such as interferons and IL-1beta. Interferons have several functions, including activating a series of intracellular signals such as Tyk2 (Tyrosine kinase 2), while IL-1beta is important for the induction of inflammation, which helps directly to protect the body against attack. However, inflammation must be kept tightly in check as it may also harm the body. Cells control IL-1beta activity in a number of ways, regulating not only the amount of messenger RNA (mRNA) that encodes the IL-1beta protein but also the processing and release of "mature" IL-1beta protein. Surprisingly, interferons may also inhibit the production of IL-1b protein and thus suppress inflammation. This conclusion comes from Marta Radwan and Rita Stiefvater in Birgit Strobl's group at the University of Veterinary Medicine, Vienna and is published in the current issue of the Journal of Immunology.

Radwan and Stiefvater have shown that cells control the way in which the IL-1beta mRNA is used to make IL-1beta protein. They measured the levels of IL-1beta protein in cells that lack Tyk2, one of the key components of the interferon signalling pathway. Although the amount of IL-1beta protein in these cells was increased, the amount of IL-1beta mRNA was not affected by the absence of Tyk2 and there was no apparent change to the stability of the mRNA. Instead the mRNA was more actively translated (copied) to protein and Radwan and Stiefvater were able to prove that the effect stemmed from a heightened association with polysomes, the complexes that actively synthesize proteins.

Interferons have long been known to inhibit translation of mRNAs in general but there have been recent indications that they may also stimulate the translation of particular mRNAs. IL-1beta is known to be involved in a wide range of autoimmune and inflammatory diseases, conditions in which the immune system either overreacts or reacts against itself. IL-1beta thus represents an attractive target for treatment of such diseases. As Birgit Strobl says, "The novel mode of IL-1beta regulation and the finding that interferon can inhibit IL-1beta production could turn out to be very important." Indeed, the finding that Tyk2 may inhibit the production of IL-1beta protein might have consequences for the development of strategies for the treatment of these widespread and serious conditions.


'/>"/>

Contact: Birgit Strobl
birgit.strobl@vetmeduni.ac.at
University of Veterinary Medicine -- Vienna
Source:Eurekalert

Related biology news :

1. Scientists identify novel inhibitor of human microRNA
2. Conaway Lab identifies novel mechanism for regulation of gene expression
3. LIAI launches new division to look at novel approaches to heart disease and inflammation
4. Childrens National researchers develop novel anti-tumor vaccine
5. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
6. Novel publishing approach puts textbook in more hands
7. GEN reports on novel tools for deciphering biological networks
8. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
9. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
10. Corn researchers discover novel gene shut-off mechanisms
11. A novel target for therapeutics against Staph infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... 2016 NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ... March 21 st .  The commercials will air on Bloomberg ... on the Street show. --> NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ...
(Date:3/11/2016)... 11, 2016 --> ... report "Image Recognition Market by Technology (Pattern Recognition), by ... by Deployment Type (On-Premises and Cloud), by Industry Vertical ... by MarketsandMarkets, the global market is expected to grow ... Billion by 2020, at a CAGR of 19.1%. ...
(Date:3/9/2016)... This BCC Research report provides an overview ... Sequencing (RNA Seq) market for the years 2015, 2016 ... reagents, data analysis, and services. Use this ... market such as RNA-Sequencing tools and reagents, RNA-Sequencing data ... each segment and forecast their market growth, future trends ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... PathSensors, ... Scientific Advisory Board. Dr. Lamka will assist PathSensors in expanding the use of ... PathSensors deploys the CANARY® test platform for the detection of harmful pathogens, including ...
(Date:4/27/2016)... , ... April 27, 2016 , ... Global Stem ... GSCG Advisory Board. Ross is the founder of GSCG affiliate Kimera Labs in Miami. ... where he studied hematopoietic stem cell transplantation for hematologic disorders and the suppression of ...
(Date:4/27/2016)... MedDay, a biotechnology company focused on the treatment of ... as Chairman of its Board of Directors. Catherine ... who contributed to the rapid development of the Company since ... her career in strategy consulting and investment banking in ...  She held C-Suite level roles in some of ...
(Date:4/26/2016)... LOS ANGELES, Calif. (PRWEB) , ... April 27, ... ... Los Angeles office of Lewis Roca Rothgerber Christie LLP as an associate in ... and prosecuting U.S. and international electrical, mechanical and electromechanical patent applications. He has ...
Breaking Biology Technology: