Navigation Links
Interactions between substances determine allergenic potential
Date:12/20/2011

Scientists at the University of Gothenburg, Sweden, have used advanced light microscopy to show that a substance can be differently absorbed by the skin, depending on what it is mixed with. This may determine whether it causes contact allergy or not.

"We have also been able to identify specific cells and proteins in the skin with which a contact allergen interacts. The results increase our understanding of the mechanisms behind contact allergy", says Carl Simonsson at the Department of Chemistry, University of Gothenburg.

The skin is the largest organ in the human body and plays many vital roles, one of which is to prevent harmful microorganisms from invading the body. The principal barrier is constituted by a layer of skin cells around a few microns thick, known as the "stratum corneum". Despite being so thin, this layer effectively protects us from e.g. bacteria and viruses.

The skin, however, is not adapted to deal with and prevent absorption of many of the chemicals that we are exposed to today. This may lead to various types of diseases, such as contact allergy, which affects approximately 20% of people in Sweden.

The work presented in Carl Simonsson's thesis describes the use of an advanced form of light microscopy known as "two-photon microscopy", which makes it possible to follow substances absorbed into the skin. The method is unique in that it allows us to see not only how well a substance is absorbed, but also what happens to it, and the location in the skin that the substance eventually comes to.

The skin barrier and the way in which various substances are absorbed are highly significant also for the development of new drugs. Creams and ointments are for many reasons an interesting alternative to tablets, which have to be taken by mouth. The barrier properties of the skin may in this case present an obstacle to drug absorption, making it difficult for sufficient amounts of the drug to penetrate the skin to give
'/>"/>

Contact: Carl Simonsson
carl.simonsson@chem.gu.se
46-317-869-110
University of Gothenburg
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. New method provides panoramic view of protein-RNA interactions in living cells
4. Social interactions can alter gene expression in the brain, and vice versa
5. Researchers unzip molecules to measure interactions keeping DNA packed in cells
6. Research explores interactions between nanomaterials, biological systems
7. New windows opened on cell-to-cell interactions
8. Interactions with aerosols boost warming potential of some gases
9. Method of the future uses single-cell imaging to identify gene interactions
10. Protein-bait interactions, display libraries featured in Cold Spring Harbor Protocols
11. MicroRNA network study implicates rewired interactions in cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Interactions between substances determine allergenic potential
(Date:4/1/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces the second shipment of a ... early access pre-order customers. Feedback from ... including Walmart, Target, AT&T, Dunkin, Donuts, Stop & Shop ... all outlets and very easy to use. Several users ...
(Date:4/1/2015)... 2015   Medisafe ™, the leading global medication ... iOS and Android smartphones and tablets, ... the platform to allow patients to track and correlate ... time, patients will be able to visualize in real-time ... biometrics, such as glucose levels and blood pressure. ...
(Date:3/31/2015)... -- Elephant Talk Communications Corp. (NYSE MKT: ETAK) ("Elephant Talk" ... Network Architecture (ET Software DNA® 2.0) platforms and cyber ... million for the year ended December 31, 2014 as ... ended December 31, 2013. At the ... multi-year transition away from its legacy landline business to ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
... 2012 Childhood Obesity , a peer-reviewed journal from Mary ... dedicated to the role that schools can and should ... eating habits to help stem the tide of the ... provides comprehensive coverage of food policy, systems, and programs ...
... becomes extinct, other predatory species could soon follow, according to ... a University of Exeter team has now carried out the ... 2012) in the Royal Society journal Biology Letters , ... can indirectly cause another to become extinct. The University of ...
... Biofuels and Texas AgriLife Research, part of The Texas ... develop and commercialize cellulosic feedstocks for the production of ... diverse high biomass energy crop breeding program and BP ... companies growing commercial-scale biomass crops for liquid fuels. ...
Cached Biology News:School food -- on the front line in the fight against childhood obesity 2Study proves that 1 extinction leads to another 2BP Biofuels, Texas AgriLife Research sign agreement to advance biofuel feedstock development 2
(Date:4/1/2015)... and NEW YORK , ... (NASDAQ:  PTBI), a biopharmaceutical company advancing protein biologic ... an overview of the Company,s 2014 achievements and ... below demonstrate the progress the Company has made ... corporate partnerships for its MuGard programs, the FDA ...
(Date:4/1/2015)... NEW YORK CITY and LONDON ... of market research reports and solutions, MarketResearch.com is pleased to ... will be a year of market growth and opportunity for ... stem cell company or cord blood bank, competing in the ... market conditions, predict industry trends, and act on market changes ...
(Date:4/1/2015)... OXFORD, England , April 1, 2015 /PRNewswire/ ... world-leading biotechnology company developing novel biological drugs to ... today pleased to announce the appointment of ... Coughlin will be responsible for providing medical and ... for the Company. Dr. Coughlin has ...
(Date:3/31/2015)... 2015 Eastern Kentucky University is ... bachelor’s of criminal justice degree programs by Nonprofitcollegesonline.com. ... inspiring ideas and high quality educational opportunities,” Editor ... University. We are confident that students will find ... is the site’s first “Students before Profits” list, ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 2PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 3PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 4PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 5PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 6MarketResearch.com: "Blockbuster" Year for Stem Cells Creates Market Opportunities, Says BioInformant Worldwide Report 2MarketResearch.com: "Blockbuster" Year for Stem Cells Creates Market Opportunities, Says BioInformant Worldwide Report 3MarketResearch.com: "Blockbuster" Year for Stem Cells Creates Market Opportunities, Says BioInformant Worldwide Report 4Immunocore Appoints Dr. Christina Coughlin as Chief Medical Officer 2Immunocore Appoints Dr. Christina Coughlin as Chief Medical Officer 3Immunocore Appoints Dr. Christina Coughlin as Chief Medical Officer 4EKU Ranked in Top 50 Among Online Criminal Justice Degrees 2
... Memory,Pharmaceuticals Corp. (Nasdaq: MEMY ) today ... the Company,s request for an,extension until December 3, ... market capitalization requirement of $35 million or the ... order to remain,listed. There can be no assurance ...
... Aortic ... Aneurysms, ... of Vascular Surgery was the first to implant, in,Phoenix, the Powerlink ... aortic aneurysms (AAA). The procedure was,performed at Arizona Heart Hospital by ...
... BOSTON, Oct. 31 PAREXEL International,Corporation (Nasdaq: ... at the,Oppenheimer 19th Annual Healthcare Conference in New ... Financial Officer will be making,a formal presentation on ... 3,2008., The presentation will be available under ...
Cached Biology Technology:Memory Pharmaceuticals Granted Extension to Comply with NASDAQ Listing Requirements 2Arizona Heart Institute First to Implant Powerlink XL in Phoenix, Arizona Since FDA Approval 2Arizona Heart Institute First to Implant Powerlink XL in Phoenix, Arizona Since FDA Approval 3PAREXEL International to Present at Oppenheimer 19th Annual Healthcare Conference 2
QPRT Immunogen: QPRT (NP_055113, 198 a.a. ~ 298 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
...
Rabbit polyclonal to XTP4 ( Abpromise for all tested applications). entrezGeneID: 84299 SwissProtID: Q9BRT3...
...
Biology Products: