Navigation Links
Interactions between substances determine allergenic potential
Date:12/20/2011

Scientists at the University of Gothenburg, Sweden, have used advanced light microscopy to show that a substance can be differently absorbed by the skin, depending on what it is mixed with. This may determine whether it causes contact allergy or not.

"We have also been able to identify specific cells and proteins in the skin with which a contact allergen interacts. The results increase our understanding of the mechanisms behind contact allergy", says Carl Simonsson at the Department of Chemistry, University of Gothenburg.

The skin is the largest organ in the human body and plays many vital roles, one of which is to prevent harmful microorganisms from invading the body. The principal barrier is constituted by a layer of skin cells around a few microns thick, known as the "stratum corneum". Despite being so thin, this layer effectively protects us from e.g. bacteria and viruses.

The skin, however, is not adapted to deal with and prevent absorption of many of the chemicals that we are exposed to today. This may lead to various types of diseases, such as contact allergy, which affects approximately 20% of people in Sweden.

The work presented in Carl Simonsson's thesis describes the use of an advanced form of light microscopy known as "two-photon microscopy", which makes it possible to follow substances absorbed into the skin. The method is unique in that it allows us to see not only how well a substance is absorbed, but also what happens to it, and the location in the skin that the substance eventually comes to.

The skin barrier and the way in which various substances are absorbed are highly significant also for the development of new drugs. Creams and ointments are for many reasons an interesting alternative to tablets, which have to be taken by mouth. The barrier properties of the skin may in this case present an obstacle to drug absorption, making it difficult for sufficient amounts of the drug to penetrate the skin to give
'/>"/>

Contact: Carl Simonsson
carl.simonsson@chem.gu.se
46-317-869-110
University of Gothenburg
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. New method provides panoramic view of protein-RNA interactions in living cells
4. Social interactions can alter gene expression in the brain, and vice versa
5. Researchers unzip molecules to measure interactions keeping DNA packed in cells
6. Research explores interactions between nanomaterials, biological systems
7. New windows opened on cell-to-cell interactions
8. Interactions with aerosols boost warming potential of some gases
9. Method of the future uses single-cell imaging to identify gene interactions
10. Protein-bait interactions, display libraries featured in Cold Spring Harbor Protocols
11. MicroRNA network study implicates rewired interactions in cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Interactions between substances determine allergenic potential
(Date:7/11/2014)... OAK RIDGE, Tenn., July 11, 2014--Researchers at the ... received eight R&D 100 awards, presented by R&D ... innovations. , "These awards recognize the tremendous ... Energy Ernest Moniz. "Research and development at the ... its energy challenges and pursue the scientific and ...
(Date:7/11/2014)... for Bone and Mineral Research awarded Michael F. Holick, ... with the 2014 Louis V. Avioli Award. Holick, a ... internationally known for revolutionizing the understanding of vitamin D ... award honors a member of the American Society for ... bone and mineral basic research. It is named for ...
(Date:7/11/2014)... Stem Cell scientists have set a "mouse TRAP" to ... by a recent study published in the Journal ... uses a technique called TRAP to extract cellular and ... Invented by scientists at the Rockefeller Institute for Medical ... to the protein-making machinery, or ribosomes, of the cell ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... leading provider of,embedded speech solutions today announced the ... AG, according to SVOX CEO Volker Jantzen.,SVOX has ... developed,over 25 years, including the SpeechAdvance(TM) speech recognition ... majority of the Professional,Speech Processing Group,s employees will ...
... MAYWOOD, Ill. -- Most people know that too much sodium ... suggests that people trying to lower their blood pressure should ... effect to sodium. Researchers found that the ratio of ... cardiovascular disease than sodium or potassium alone. "There ...
... officials from the U.S. National Science Foundation and the ... today marked the occasion of the research vessel JOIDES ... and transit to Honolulu, after a complete transformation to ... The JOIDES Resolution is the U.S. research ...
Cached Biology News:SVOX Acquires Speech Processing Unit of Siemens AG, Expands Into Speech Recognition and Speech Dialog 2Cutting salt isn't the only way to reduce blood pressure 2Ocean research officials hail completion of modernization for US scientific ocean drilling vessel 2
(Date:7/10/2014)... , July 10, 2014 /PRNewswire-iReach/ -- Tute ... interpretation, today announced an agreement with Lineagen, ... for Lineagen,s NextStep Dx PLUS.  Lineagen, ... and neurological disorders, currently offers FirstStep Dx ... testing service used by healthcare providers as ...
(Date:7/10/2014)... the fight against terrorism with the creation of a ... the use of light and special glass fibres. , ... Chemical , the researchers describe a novel optical fibre ... as 6.3 ppm (parts per million). It requires an ... explosives detection has involved looking for metals that encase ...
(Date:7/10/2014)... Columbia researchers have observed the fractional quantum Hall effect ... of matter can be tuned by an electric field. ... occur when electrons confined to thin sheets are exposed ... collective behavior where thousands of individual electrons behave as ... this effect is well established, many details of this ...
(Date:7/10/2014)... researchers at the University of Illinois at Urbana-Champaign ... the interplay of spin and heat at the ... spintronic devices for data storage and information processing. ... as spin-angular momentum. In a typical charge current, ... spin current," explained David Cahill, a professor of ...
Breaking Biology Technology:Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3University of Illinois study advances limits for ultrafast nano-devices 2
... in the late 1970s with the first IPOs taking place in ... than 25 years old. , ,An interesting article in Genetic ... that most industry cycles run about 50 years until they mature. ... 50-year cycle. A new industry of significance usually produces an industrial ...
... In a long-planned departure from its traditional focus, high-end ... the U.S. Army for development of two different products. ... that it has secured $2.2 million in federal contracts ... with the Armys Research, Development and Engineering Command (CERDEC) ...
... Mike Strand has always kept his eye out ... Delta Technology and Cray Research, Strand took a stride forward ... company based out of his home dealing with barcode software. ... had expanded into a worldwide enterprise bringing in close to ...
Cached Biology Technology:Biotech industry reaches midpoint in 50-year maturation cycle 2Biotech industry reaches midpoint in 50-year maturation cycle 3Biotech industry reaches midpoint in 50-year maturation cycle 4Biotech industry reaches midpoint in 50-year maturation cycle 5SLE of Eau Claire lands $2.2 million in federal contracts 2SLE of Eau Claire lands $2.2 million in federal contracts 3Online Kiosks founder Mike Strand uses contest to screen new business plan 2Online Kiosks founder Mike Strand uses contest to screen new business plan 3
... workstation is the simplest, easiest-to-use system ever ... liquid handling capabilities,into their labs, or groups ... routine applications on a separate instrument. Plate-handling ... even when you have thousands of ...
... has generated hybridomas against a large ... initiation, you are provided with personalized ... cell lines developed by Covance remain ... typical hybridoma development project has four ...
... cDNA normalization is essential for ... using high-throughput approaches, such as EST ... Most normalization methods are not well ... cDNA. The Evrogen TRIMMER kit, though, ...
... ENGENISTM (Entire Gene/cDNA or Isolated Sequence) siRNA ... quantitative approach for evaluation of a potential ... an efficient target for RNA interference (RNAi). ... not perfect, leaving the probability of selected ...
Biology Products: