Navigation Links
Interactions between substances determine allergenic potential
Date:12/20/2011

Scientists at the University of Gothenburg, Sweden, have used advanced light microscopy to show that a substance can be differently absorbed by the skin, depending on what it is mixed with. This may determine whether it causes contact allergy or not.

"We have also been able to identify specific cells and proteins in the skin with which a contact allergen interacts. The results increase our understanding of the mechanisms behind contact allergy", says Carl Simonsson at the Department of Chemistry, University of Gothenburg.

The skin is the largest organ in the human body and plays many vital roles, one of which is to prevent harmful microorganisms from invading the body. The principal barrier is constituted by a layer of skin cells around a few microns thick, known as the "stratum corneum". Despite being so thin, this layer effectively protects us from e.g. bacteria and viruses.

The skin, however, is not adapted to deal with and prevent absorption of many of the chemicals that we are exposed to today. This may lead to various types of diseases, such as contact allergy, which affects approximately 20% of people in Sweden.

The work presented in Carl Simonsson's thesis describes the use of an advanced form of light microscopy known as "two-photon microscopy", which makes it possible to follow substances absorbed into the skin. The method is unique in that it allows us to see not only how well a substance is absorbed, but also what happens to it, and the location in the skin that the substance eventually comes to.

The skin barrier and the way in which various substances are absorbed are highly significant also for the development of new drugs. Creams and ointments are for many reasons an interesting alternative to tablets, which have to be taken by mouth. The barrier properties of the skin may in this case present an obstacle to drug absorption, making it difficult for sufficient amounts of the drug to penetrate the skin to give a clinical effect.

"We have used two-photon microscopy to study a new type of ointment that it may be possible to use to improve the absorption, and thus the clinical effect, of certain drugs that are used on the skin", says Carl Simonsson.


'/>"/>
Contact: Carl Simonsson
carl.simonsson@chem.gu.se
46-317-869-110
University of Gothenburg
Source:Eurekalert  

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. New method provides panoramic view of protein-RNA interactions in living cells
4. Social interactions can alter gene expression in the brain, and vice versa
5. Researchers unzip molecules to measure interactions keeping DNA packed in cells
6. Research explores interactions between nanomaterials, biological systems
7. New windows opened on cell-to-cell interactions
8. Interactions with aerosols boost warming potential of some gases
9. Method of the future uses single-cell imaging to identify gene interactions
10. Protein-bait interactions, display libraries featured in Cold Spring Harbor Protocols
11. MicroRNA network study implicates rewired interactions in cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Interactions between substances determine allergenic potential
(Date:1/25/2016)... Jan. 25, 2016  Glencoe Software, the world-leading supplier ... publication industries, will provide the data management solution OMERO ... Photo ... Phenotypic analysis measures the characteristics ... allowing comparisons between states such as health and disease, ...
(Date:1/20/2016)... 20, 2016   MedNet Solutions , an innovative ... of clinical research, is pleased to announce the attainment ... are the result of the company,s laser focus on ... , it,s comprehensive, easy-to-use and highly affordable cloud-based ... Key MedNet growth achievements in 2015 include: ...
(Date:1/13/2016)... January 13, 2016 ... addition of the  "India Biometrics Authentication ... Forecast (2015-2020)"  report to their ... has announced the addition of the  ... - Estimation & Forecast (2015-2020)" ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... PA (PRWEB) , ... February 09, 2016 , ... With ... the 2016 Wharton Health Care Business Conference will bring together over 500 top healthcare ... for an industry in transformation. The conference, organized by MBA students of the University ...
(Date:2/9/2016)... ... February 09, 2016 , ... Tunnell Consulting, Inc. announced that Frédéric Lefebvre has ... focus on acquiring new accounts and work closely with existing Tunnell clients throughout Europe ... to our European clients more than 15 years of experience in the pharmaceutical industry, ...
(Date:2/9/2016)... , Feb. 9, 2016 This market ... the current and future prospects of the market in ... report include companies engaged in the manufacture of microbiology ... executive summary with a market snapshot providing the overall ... of this report. This section also provides the overall ...
(Date:2/8/2016)... , Feb. 8, 2016 /PRNewswire/ - BIOREM Inc. (TSXV: ... the top ten finalists for clean technology companies in the ... the top 10 companies listed on the TSX Venture Exchange, ... & gas, clean technology & life sciences, diversified ... equal weighting given to return on investment, market cap growth, ...
Breaking Biology Technology: