Navigation Links
Interaction of just 2 genes governs coloration patterns in mice
Date:8/13/2007

ce' have evolved a lighter pigmentation than their mainland relatives, a coloration that helps camouflage them from predators that include owls, herons, and hawks."

Previous research has shown that such predators, all of which hunt by sight, will preferentially catch darker mice on the white sand beaches, providing a powerful opportunity for natural selection to evolve increased camouflage.

Through a detailed genomic analysis, Hoekstra, Steiner, and Weber identified two pigmentation genes, for the melanocortin-1 receptor (Mc1r) and an agouti signaling protein (Agouti) that binds to this receptor and turns it off. A single amino-acid mutation in Mc1r gene can weaken the receptor's activity, or a mutation in the Agouti gene can increase the amount of protein present without changing the protein's sequence, also reducing Mc1r activity and yielding lighter pigmentation.

Both genes affect the type and amount of melanin in individual hairs. When both genes are turned on, the mouse is dark in color. A mutation that changes either gene leads to a somewhat blonder mouse, but it is the combination of mutations in both genes that produces a mouse very light in color.

"Thus, two different types of mutations in two different genes each contribute to the light coloration of beach mice," Hoekstra says. "This work represents a first step into understanding how unique patterns of fur color are produced via a simple interaction between genes."


'/>"/>

Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Virus-host interactions at sea effect global photosynthesis
2. Future diabetes drugs may target new protein interaction
3. Computational verification of protein-protein interactions by orthologous co-expression
4. Confirmation of human protein interaction data by human expression data
5. Physical and functional interaction of key cell growth molecules linked to cancer
6. Complex gene interactions account for autism risk
7. Image of myosin-actin interaction revealed in cover story of Molecular Cell
8. A real time look at interactions between RNA and proteins
9. U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
10. Biologists visualize protein interaction that may initiate viral infection
11. Biologists develop genome-wide map of miRNA-mRNA interactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... to Research Careers) Program has announced the travel award ... Exercises Workshop which will be held on the FASEB ... These awards are meant to help support the ... in the the FASEB Grant Writing Seminar & Practical ... totaling $20,350. , The FASEB MARC Program is funded ...
(Date:8/22/2014)... are strong antioxidants and can reduce free ... neurons against oxidative stress? Jianbo Zhao and ... Liaoning Medical University, China discovered that green ... inhibit neuronal apoptosis, indicating green tea polyphenols ... neurons under oxidative stress. The relevant study ...
(Date:8/21/2014)... toxins in past decade, GTA still violates Canada,s ... while the Greater Toronto Area (GTA) has significantly ... smog, the city continues to violate the Canada-wide ... cause or aggravate health problems such as asthma, ... set of complex photochemical reactions involving volatile organic ...
Breaking Biology News(10 mins):Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2
... percent of the major global cereal crops rice, ... possible yields in farmers, fields, according to University of ... . These findings raise concerns about efforts to increase ... these crops have recently decreased or plateaued. Future projections ...
... shrub that grows on just a single island in the ... and genus. It is also one of the oldest flowering ... ago. Now, researchers from Indiana University, with the U.S. Department ... and the Institute of Research for Development in New Caledonia, ...
... constant reconfiguration of the connections between nerve cells. Two ... mechanisms that underlie the learning process. Learning and ... nerve connections in the brain. Both processes are based ... cells the so-called synapses which alter their ...
Cached Biology News:UNL research raises concerns about global crop projections 2A gluttonous plant reveals how its cellular power plant devours foreign DNA 2A gluttonous plant reveals how its cellular power plant devours foreign DNA 3Neurobiology: The logistics of learning 2Neurobiology: The logistics of learning 3
(Date:8/22/2014)... 22, 2014 Nerium International, the ... in the spotlight again. Nerium will showcase its ... NeriumFirmTM Body Contouring Cream to Hollywood’s elite at ... during the 66th Primetime Emmy® Awards. , Developed ... third-party clinical trials show that NeriumAD night cream ...
(Date:8/21/2014)... the Institute for Molecular Medicine Finland (FIMM), University ... a novel "man and machine" decision support system ... was described in PLOS One scientific ... on computer vision algorithms similar to those used ... only the diagnostically most relevant areas. Tablet computers ...
(Date:8/21/2014)... 2014 Telomere Biosciences, LLC (Telomere Biosciences) ... for Dogs" with Telomerase Activation Complex , ... world for dogs. Telomeres are the protective caps ... body. A wealth of ground-breaking research by some ... and Aging, including Nobel laureates, has demonstrated a ...
(Date:8/21/2014)... -- China Cord Blood Corporation (NYSE: CO ) ... results for the first quarter of fiscal year 2015 ... the US.  The Company will host ... August 29, 2014 to discuss its financial performance and ... followed by a question and answer session.  Interested parties ...
Breaking Biology Technology:Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2
... BioSpace and BioMed Central are announcing the ... Network today, a new online community ... job opportunities and industry news. ... http://photos.prnewswire.com/prnh/20040907/CLTU006LOGO ) (Logo: ...
... FRANCISCO, Calif.,  Sept. 15 Veracyte, Inc., a ... molecular cytology, announced that initial data from its ... at the 14th International Thyroid Congress, held in ... molecular test classified inconclusive thyroid nodule fine needle ...
... Sept. 14 /PRNewswire-FirstCall/ - Dynamic Ventures Corp. (OTC:BB: DYNV), ... term agreement with One Tree Development Inc. for rights ... commercial and residential construction nationally and internationally. One Tree ... One Tree is a corporation formed for ...
Cached Biology Technology:BioSpace and BioMed Central Create Global Career Community 2New Data Suggest Veracyte's Molecular Test Improves Accuracy of Thyroid Nodule Diagnosis Using Fine Needle Aspirate (FNA) Samples 2New Data Suggest Veracyte's Molecular Test Improves Accuracy of Thyroid Nodule Diagnosis Using Fine Needle Aspirate (FNA) Samples 3Dynamic Ventures Corporation enters into a long-term agreement that brings $50 million annual sales opportunity for wholly owned subsidiary EZ-Build. 2Dynamic Ventures Corporation enters into a long-term agreement that brings $50 million annual sales opportunity for wholly owned subsidiary EZ-Build. 3
... The QPatch sports 16-independent channels for ... is used for screening against voltage-gated ion ... such as GABA channels. The four ... faster throughput for ion channel drug discovery. ...
... systems need to be able to handle larger ... ports, as well as interface with telemetry systems. ... more, particularly with dogs, pigs, and primates. ... starting time, and the computer can be located ...
... Plate is a 96-well ELISA-compatible plate ... antibody (mouse IgG 1 ) is ... glutathione-S-transferase (GST), and binds with high ... protein in which the tag is ...
... projects are focused on sequencing, analysis of ... other areas of genomics and proteomics, EvoQuest ... meet your research and manufacturing challenges. Invitrogen ... your project from beginning to end in ...
Biology Products: