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Interaction between gene variants may alter brain function in schizophrenia
Date:11/7/2008

rtical activation patterns on their own, the combined effects of both genes did make a difference. The reduction in cortical function seen in patients with the schizophrenia-associated MTHFR variant was even more pronounced in patients who also had a COMT variant previously associated with less efficient working-memory-related brain activity.

"Based on the known effects of these alleles on brain biochemistry, it is likely that our results reflect cumulative impacts of the gene variants on dopamine signaling, particularly in the prefrontal cortex. These findings may help us to identify patients more likely to benefit from new treatments targeting the dopamine and folate systems," Roffman says. "We are hopeful that this approach will catalyze the development of individualized treatment regimens, since it will allow us to examine the effects of treatment-related genes on brain function using a much smaller groups of study participants."


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Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

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