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Interacting mutations promote diversity
Date:6/28/2012

This release is available in German.

Genetic diversity arises through the interplay of mutation, selection and genetic drift. In most scientific models, mutants have a fitness value which remains constant throughout. Based on this value, they compete with other types in the population and either die out or become established. However, evolutionary game theory considers constant fitness values to be a special case. It holds that the fitness of a mutation also depends on the frequency of the mutation. Scientists from the Max Planck Institute for Evolutionary Biology in Pln and the University of British Columbia in Vancouver developed a model to address the scenario of mutations being frequency-dependent but having random fitness parameters. The results demonstrate that the dynamics that arise in random mutants increase the genetic diversity within a population. Fitness, though, may even decline.

Population geneticists generally study mutations with constant fitness values. However, frequency-dependent selection is a recurrent theme in evolution: it enables the evolution of new species without geographical separation (sympatric speciation) or a relatively rapid change in the immune system of a population.

A mutation may be advantageous for low frequencies, for instance, but the fitness of the mutant decreases with rising frequency. A reverse trend in the fitness value is also conceivable. "Our computer model combines aspects of population genetics and evolutionary game theory in order to obtain a new perspective on genetic evolution," says Arne Traulsen from the Max Planck Institute for Evolutionary Biology. Whereas mutations have a random yet fixed fitness value in many mathematical models, this new model also enables a change in random fitness values with the frequency of the different types.

The results of the simulations show t
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Contact: Dr. Arne Traulsen
traulsen@mpil-ploen.mpg.de
49-452-276-3255
Max-Planck-Gesellschaft
Source:Eurekalert

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