Navigation Links
Intentional variation increases result validity in mouse testing
Date:3/9/2010

WEST LAFAYETTE, Ind. - For decades, the traditional practice in animal testing has been standardization, but a study involving Purdue University has shown that adding as few as two controlled environmental variables to preclinical mice tests can greatly reduce costly false positives, the number of animals needed for testing and the cost of pharmaceutical trials.

Joseph Garner, a Purdue assistant professor of animal sciences, said the finding challenges the assumption in drug discovery and related fields that animal experiments should eliminate all variables. He said that despite standardization efforts, two experiments in different labs could never truly be exactly the same because of uncontrollable variables such as the scent of the researchers or background noises.

"Human drug trials get around this problem by deliberately including variability in the experiment in a controlled manner so that the effect of a drug can be tested across a variable human population," Garner said.

Garner and his co-authors compared results from multiple mice experiments set up in a standardized manner against multiple experiments set up with controlled variables as if the mice were people.

"Overall, the differences between experiments are much, much greater in the standardized setups than in the ones where we deliberately varied the environment as if the experiment was a human drug trial," said Garner, whose results were published in the current issue of the journal Nature Methods. "In fact, the traditional standardized experiments generally disagreed with each other, while the experiments designed like a human drug trial generally agreed with each other."

The study is a follow-up of another published last year in Nature Methods in which Garner, Hanno Wrbel, a co-author on the papers and professor at the University of Giessen in Germany, and Helene Richter, Wrbel's graduate student, suggested that adding controlled
'/>"/>

Contact: Brian Wallheimer
bwallhei@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New book presents successful strategies for probing genetic variation
2. Physician-scientists seek solutions to reproductive problems related to chromosomal variations
3. Copy number variation may stem from replication misstep
4. Gene variation may elevate risk of liver tumor in patients with cirrhosis
5. DNA variations signal lupus risk
6. U-M researchers release most detailed global study of genetic variation
7. Michigan Tech researchers link 11 genetic variations to type 2 diabetes
8. Mental stress reduces blood flow to the heart in patients with gene variation
9. Genetic variation linked to sugary food
10. Statistical tool could explain gene study variations
11. Why do people vote? Genetic variation in political participation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Intentional variation increases result validity in mouse testing
(Date:4/14/2015)... April 14, 2015  HYPR Corp. today announced ... ® ) Alliance tm , an industry consortium ... commit to share technology and collaborate to deliver ... interoperable, more secure and private, and easier to ... verification that protects sensitive user information and eliminates ...
(Date:4/9/2015)... Calif. , April 9, 2015 Synaptics ... interface solutions, announced today that it will report financial ... Thursday, April 23, 2015, after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
(Date:4/2/2015)... , April 2, 2015 ... Q1 2015 attributed to somewhat higher than 125 MSEK. ... the year-end report 2014 that revenues for Q1 2015 ... the company reported for Q4 2014. The operating result ... be negative. The complete interim report will as previously ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Synaptics to Report Third Quarter Results on April 23 2Fingerprint Cards Revises Revenues for Q1 2015 2
... Lolle and colleagues from Purdue University published a paper in ... do not obey the laws of Mendelian inheritance (the idea ... found that these plants were demonstrating genetic traits from older ... of how genes are passed on. At the ...
... Bethesda, MD The Federation of American Societies ... registration for the Science Research Conference (SRC): Mechanism ... 2013 FASEB Science Research Conference on Mechanism and ... 23 in Saxton Rivers, VT. The "Vermont Transcription ...
... mid-nineteenth century, maps have helped elucidate the deadly mysteries ... global mapping of infectious diseases is considerably unreliable and ... outbreaks, according to a new systematic mapping review of ... the 355 infectious diseases assessed in the review, 174 ...
Cached Biology News:Defying the laws of Mendelian inheritance 2Avoiding a cartography catastrophe 2
(Date:4/30/2015)... 2015  The Paul G. Allen Family Foundation announced ... to six groups of researchers with projects at the ... neuroscience: growing mature human brain cells in the laboratory. ... million over three years.  "This new ... especially significant because the field of neuronal maturation is ...
(Date:4/30/2015)... 2015 Available in select spas ... , Fleur’s introduces CC CRÈME ... benefits of makeup, skin care and solar protection ... is designed with specific complexion-correcting pigments to instantly ... and a healthy glow. Far more than a ...
(Date:4/29/2015)... According to a new market ... (Portable & Non-Portable), Component (Accelerometer, Proximity Probe, & ... & Mining, & Others), & Geography - Global ... to reach $1,453.76 Million by 2020, at a ... tables and 92 figures spread through 205 pages ...
(Date:4/29/2015)... AlloSource ®, one of the ... and soft-tissue allografts for use in surgical procedures ... the launch of AlloSkin™ AC, an acellular dermal ... (CMS) also moved AlloSkin™ RT, a meshed human ... category for reimbursement. "AlloSource is committed ...
Breaking Biology Technology:The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 4The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 5Fleur’s Introduces CC CRÈME Perfect Skin Solution 2Fleur’s Introduces CC CRÈME Perfect Skin Solution 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 4AlloSource Announces New Possibilities In Wound Care 2
... EMERYVILLE, Calif., Jan. 3, 2012  Bionovo, Inc. (NASDAQ: ... discovery and development of safe and effective treatments for ... entered into a $5 million securities purchase agreement with ... Socius Capital Group, LLC. (Logo: ...
... Jan. 3, 2012 Dear NeoStem Shareholders, ... back at 2011 - a transformative year for NeoStem (NYSE Amex: ... term catalysts that we expect to move the company forward in ... Progenitor Cell Therapy, LLC ("PCT") and Amorcyte, LLC ("Amorcyte"). , ...
... NEW YORK, Jan. 3, 2012 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p0203539/Cytogenetics---technologiesmarkets-and-companies.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics ... cytogenetics in a broader sense rather than ...
Cached Biology Technology:Bionovo Announces $5 Million Financing 2Bionovo Announces $5 Million Financing 3Bionovo Announces $5 Million Financing 4NeoStem's CEO Letter to Shareholders 2NeoStem's CEO Letter to Shareholders 3NeoStem's CEO Letter to Shareholders 4Cytogenetics - Technologies, Markets and Companies 2Cytogenetics - Technologies, Markets and Companies 3Cytogenetics - Technologies, Markets and Companies 4Cytogenetics - Technologies, Markets and Companies 5Cytogenetics - Technologies, Markets and Companies 6Cytogenetics - Technologies, Markets and Companies 7Cytogenetics - Technologies, Markets and Companies 8Cytogenetics - Technologies, Markets and Companies 9Cytogenetics - Technologies, Markets and Companies 10Cytogenetics - Technologies, Markets and Companies 11
Request Info...
...
... to Atrophin 1 ( Abpromise for ... Synthetic peptide conjugated to KLH derived ... of Human Atrophin 1.(Note: the amino acid ... .) Entrez GeneID: ...
An excellent carbonyl-reactive FRET quencher paired with Trp or Tyr. Minimum Purity: 95%. Abs(max): ~350 nm; Em(max): none. Solvent System:DMSO or DMF....
Biology Products: