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Intense prep for law school admission test alters brain structure
Date:8/22/2012

Mackey and Bunge tested for changes in the white matter of the brain, the brain tissue that contains the connections between the brain's neurons. These connections, called axons, are surrounded by a variety of support cells called glia, some of which form myelin that insulates the axons and speeds the passage of signals. In animal studies, increased myelination and glial support cells are associated with learning, and a recent study found that some of these glial cells provide energy to the axons.

Using diffusion tensor imaging (DTI), they followed water movement in the white matter and found differences, on average, between the trained group and the control group. Specifically, the trained group showed a change in the directionality of water diffusion that is consistent with increased myelination. Also, near the boundary between the white matter and gray matter, the trained group showed a reduction in water diffusion, possibly because of more densely packed glial cells. While the real cause of the changes in water diffusion is unclear, the researchers said, it reflects an alteration in the microstructure of the brain associated with a change in cognitive activity.

"One thing that gives us confidence in these data is that a lot of these changes are in the tracts that connect frontal and parietal cortex, or between different hemispheres in those areas, and frontal and parietal regions are absolutely essential for reasoning," Bunge said. "So, we are seeing the changes exactly where we would expect to see them. And we think that they reflect strengthening of the connections between them."

"This work could inspire further research in non-human animals, because there seems to be a resurgence of interest in environmental influences on the brain," Bunge said, noting that, in the 1960s and '70s, UC Berkeley Professors Mark Rosenzweig and Marion Diamond conducted landmark research on the effects of environmental enrichment on behavior and brain ana
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Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

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