Navigation Links
Intelligent design: Engineered protein fragment blocks the AIDS virus from entering cells
Date:3/31/2011

In what could be a potential breakthrough in the battle against AIDS and a major development in the rational design of new drugs, scientists have engineered a new protein that prevents the virus from entering cells. This protein is based on a naturally occurring protein in the body that protects cells from viruses, except the man-made version does not cause inflammation and other side effects at the dosages needed to inhibit AIDS. This discovery was published in the April 2011 issue of The FASEB Journal (http://www.fasebj.org).

"This is science fiction made reality. These researchers took a protein apart and removed the portion that causes harm, then stabilized and modified the section that has a therapeutic effect," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Not only is this good news for people with AIDS, it's good news for all of us as this research paves the way for similar work for many, many other illnesses."

The protein fragment is based on a naturally occurring protein called RANTES, which is part of the body's immune system. RANTES naturally defends the body against HIV/AIDS, but cannot be used as a drug or drug candidate because it has several other biological effects which could cause harmful inflammation. After examining the precise molecular structure of the RANTES protein, the researchers discovered that only a small fragment of the RANTES protein is actually responsible for blocking HIV entry into cells. From there, they dissected the desired section of the RANTES protein and worked to stabilize it without compromising its protective effects. After several sequential steps of molecular refinement and some virtual modeling, the researchers created a peptide with very high potency against HIV, with possible benefits for treating inflammatory diseases such as arthritis and lupus, as well as the prevention of transplant rejection.

"We're finally
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Engineers create intelligent molecules that seek-and-destroy diseased cells
2. Intelligent people have unnatural preferences and values that are novel in human evolution
3. UI researchers analyze implications of intelligent design for human behavior
4. Innovative research reawakens human memories through intelligent textiles
5. Engineered pig stem cells bridge the mouse-human gap
6. Genetically engineered mice yield clues to knocking out cancer
7. First genetically-engineered malaria vaccine to enter human trials
8. Engineered tobacco plants have more potential as a biofuel
9. Bioengineered materials promote the growth of functional vasculature, new study shows
10. Genetically engineered tobacco plant cleans up environmental toxin
11. Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... parents of preterm babies latest research from the ... become teenagers, the brains of many preterm children can perform ... study conducted by the University,s Robinson Research Institute ... no brain injury in early life, their cognitive abilities as ... peers. , However, the results of the study, published in ...
(Date:7/28/2014)... approved by the U.S. Food and Drug Administration (FDA) ... certain bacterial pathogens inside human cells, including those that ... findings, published in mBio , the online open-access ... new way of identifying non-antibiotic drugs that could one ... of drugs on the list inhibit the growth of ...
(Date:7/28/2014)... Ariz. - Reactions among minerals and organic compounds in ... carbon cycle, they provide energy for the deep biosphere, ... However, very little is known about how minerals influence ... State University have demonstrated how a common mineral acts ... negating the need for toxic solvents or expensive reagents. ...
Breaking Biology News(10 mins):Preterm children's brains can catch up years later 2New route to identify drugs that can fight bacterial infections 2Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3
... for Research in Vision and Ophthalmology (ARVO) is pleased ... recipients will be acknowledged at the ARVO 2012 Annual ... Proctor Medal: Peter Sterling, PhD, Mildred Weisenfeld Award ... FARVO, Cogan Award: Jeffrey L. Goldberg, MD, PhD, Friedenwald ...
... AMHERST, Mass. A team of kinesiology researchers led ... Amherst recently received a 2.5-year, $975,000 grant through the ... to study how the average 100-lb. equipment load carried ... missions, affects their survivability, likelihood of injury and ability ...
... Md. - The first Maryland municipality to earn a ... is the Town of Berlin on the Eastern Shore. ... by the University of Maryland,s Environmental Finance Center - ... as well as revitalize and improve their long-term quality ...
Cached Biology News:2012 ARVO Award recipients honored at annual meeting 2Kinesiology team gets $975,000 Defense grant to study effects of heavy loads on soldiers 2Maryland gets its first 'Certified Sustainable' community: Berlin 2
(Date:7/30/2014)... 2014 LayerBio, Inc., an MIT spinoff ... first round of seed financing from friends and family ... to develop a novel sustained-release product for ophthalmology. , ... and their commitment to this important work," said Dr. ... one of many areas in which innovations in drug ...
(Date:7/29/2014)... technologists have hurdled a number of significant technological ... revolutionary observing technology originally created for the James ... Principal Investigator Harvey Moseley, a scientist at NASA,s ... demonstrated that electrostatically actuated microshutter arrays that ... are as functional as the current technology,s ...
(Date:7/29/2014)... 2014 Human Longevity, Inc. (HLI), a genomics ... extending the healthy, high performance human life span, today ... an expert in machine learning and machine translation as ... from Google where he was Distinguished Research Scientist and ... to HLI Co-Founder and CEO, J. Craig Venter ...
(Date:7/29/2014)... a new way of manufacturing microstructured surfaces that ... self-assembly of carbon nanotubes, could exhibit a variety ... and strength, or the ability to repel water ... that mechanical forces can be used to direct ... we can independently control the mechanical properties ...
Breaking Biology Technology:Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3A new way to make microstructured surfaces 2
... WuXi PharmaTech (NYSE:,WX), a leading pharmaceutical, biotechnology and ... in China and the United,States, today announced that ... Vice,President of Strategy., (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ... Yu worked at Pfizer Inc., where,she co-led Pfizer,s ...
... Archi-Tech Systems, a,leading provider of pharmaceutical ... PromoTrack, a new solution custom-designed to,rapidly measure ... promotions. Archi-Tech has tailored its proven DART ... marketers, seamlessly,integrating disparate promotional campaign and Rx ...
... Inc.,(TSX: SDI) today announced that it has entered ... Medical for Spectral,s Endotoxin,Activity Assay (EAA(TM)), the only ... the terms of the agreement, BB Medical will ... "BB Medical is a leading distributor of medical ...
Cached Biology Technology:WuXi PharmaTech (NYSE: WX) Appoints Dr. Debra Yu as VP of Strategy 2Pharmaceutical Marketing Done Right: Archi-Tech Systems Unveils Version of Proven Analytics Solution for Campaign Management 2Spectral announces exclusive distribution agreement in Russia for its EAA(TM) Sepsis Diagnostic Assay 2
Designed for use with the Agencourt CleanSEQ and Agencourt AMPure 384-well SPRI reagent kits. For use with 384-well thermal cycling plates....
... Removal , , Removes ... cross-reactivity with other proteins , Simple, just ... Economical new surface technology, not based on ... with protein analysis. SurfactAway offers a simple ...
... SDS and Non-ionic Detergent Removal ... , Very selective, virtually no cross-reactivity with ... and discard pellet , Economical new ... , Detergents can often interfere with protein ...
... 3000 workstation automates a wide array of ... Proteomic Sample Preparation to Bio-Molecular and Cell ... of the Caliper Sciclone enables numerous combinations ... meet the needs of a given application, ...
Biology Products: