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Insulin's brain impact links drugs and diabetes
Date:10/17/2007

ese important dopamine neurotransmitter systems and insulin signaling mechanisms, which we know are altered in diabetes

The results are some of the first to link insulin status and dopaminergic brain function and hold several implications for human health and disease.

This is really the first mechanistic connection in vivo between diabetes and amphetamine action, Galli said. This offers a completely new perspective on the influence of this disease (diabetes) on brain function, as well as diseases with altered dopamine signaling, such as schizophrenia and ADHD.

The findings suggest that ADHD risk may have an insulin-dependent component and that control of insulin levels and response to the hormone may be an important determinant of amphetamine efficacy in patients with ADHD, Galli noted.

We have described a novel mechanism by which diabetes may affect brain function.


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Contact: Melissa Marino
melissa.marino@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

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