Navigation Links
Insulin's brain impact links drugs and diabetes
Date:10/17/2007

Insulin, long known as an important regulator of blood glucose levels, now has a newly appreciated role in the brain.

Vanderbilt University Medical Center researchers, working with colleagues in Texas, have found that insulin levels affect the brains dopamine systems, which are involved in drug addiction and many neuropsychiatric conditions.

In addition to suggesting potential new targets for treating drug abuse, the findings raise questions as to whether improper control of insulin levels as in diabetes may impact risk for attention deficit hyperactivity disorder (ADHD) or influence the effectiveness of current ADHD medications.

The study, led by Aurelio Galli, Ph.D., in the Center for Molecular Neuroscience and Calum Avison, Ph.D., in the Institute of Imaging Science (VUIIS), appears online this week in the Public Library of Science Biology (PLoS Biology).

The psychostimulant drugs amphetamine and cocaine, as well as related medications for ADHD, block the reuptake of the neurotransmitter dopamine by dopamine transporters (DATs) and increase the level of dopamine signaling. Some of these compounds, including amphetamine, also cause a massive outpouring of dopamine through DATs.

The resulting surge of synaptic dopamine alters attention, increases motor activity and plays an important role in the addictive properties of psychostimulants.

But the link between insulin status and dopaminergic function is not readily apparent.

In the 1970s, there were articles showing that, in animals with type 1 diabetes, psychostimulants like amphetamine would not increase locomotor behavior, said Galli, associate professor of Molecular Physiology and Biophysics. We didnt have a clear understanding of why that was happening.

This sparked Galli and colleagues to investigate the link between insulin signaling and amphetamine action.

Using a rat model of type 1 or juvenile diabetes in which i
'/>"/>

Contact: Melissa Marino
melissa.marino@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Controversial drug shown to act on brain protein to cut alcohol use
2. Drug That Tags Decision-making Areas Of The Brain May Aid
3. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
4. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
5. Mouse brain tumors mimic those in human genetic disorder
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. First atlas of key brain genes could speed research on cancer, neurological diseases
8. Transport System Smuggles Medicines Into Brain
9. Bird Brains Show How Trial and Error May Contribute to Learning
10. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
11. Wiley announces publication of Databasing the Brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... TX (4/23/14) -- Researchers have found evidence of ... factors that increase aggressive behavior in children, especially ... not all children exposed to prenatal smoking will ... will not," said Brian Boutwell, Assistant Professor at ... and senior author on the study. "One ...
(Date:4/23/2014)... away from using triclosan as an antimicrobial ingredient in ... now scientists are reporting new evidence that appears to ... journal Chemical Research in Toxicology , found that ... promoted the growth of human breast cancer cells in ... Kyung-Chul Choi and colleagues note that hormonal imbalances seem ...
(Date:4/23/2014)... comprehensive study to date of the family of ... effective vaccine strategies and reveals surprising findings about ... could alter public health strategies to control this ... year. , Genomic analysis of 343 strains of ... the world collected over the last 100 years ...
Breaking Biology News(10 mins):Genetics risk, prenatal smoking may predict behavioral problems 2In lab tests, the antimicrobial ingredient triclosan spurs growth of breast cancer cells 2Impact of whooping cough vaccination revealed 2
... Scheduling more physical education time in schools does not ... research that discovered those who got lots of timetabled ... while those who got little at school made up ... The scientists, who presented their research Thursday at the ...
... Inc. (Nasdaq: AWRE ), a leading supplier of ... its first quarter ended March 31, 2009. Revenues for ... of 22% compared to $5.9 million in the same quarter ... and diluted net income per share in accordance with U.S. ...
... Desert environments are characterized by poor vegetative cover, ... conditions. In this context, the land resources of ... are subjected to various land degradation stresses, including ... sustain the land resources of Abu Dhabi Emirate, ...
Cached Biology News:Study finds children's activity levels not influenced by more PE time in school 2Aware, Inc. Reports First Quarter 2009 Financial Results 2Aware, Inc. Reports First Quarter 2009 Financial Results 3Aware, Inc. Reports First Quarter 2009 Financial Results 4Aware, Inc. Reports First Quarter 2009 Financial Results 5Aware, Inc. Reports First Quarter 2009 Financial Results 6Wind, salt and water are leading indicators of land degradation in Abu Dhabi 2
(Date:1/14/2014)... EquitiesIQ, a leading informational research provider, has ... an emerging biomedical company acquiring, developing, manufacturing, and marketing ... Free report download: http://equitiesiq.com/reports/alliqua/ , In late ... and Board, which launched the company’s new strategy to ...
(Date:1/14/2014)... January 14, 2014 In recent years, ... and methods in product development and promotion has led ... This mistrust, fueled by concerns about the insidious impact ... reports of spectacular fines to the world’s biggest pharmas ...
(Date:1/14/2014)... Cardiff, UK (PRWEB) January 13, 2014 ... leader with more than 20 years in the industry, ... and photonics . Hainsey will serve as the society’s ... have Dr. Hainsey join SPIE as our Technology Strategist, ...
(Date:1/14/2014)... Triangle Park, NC (PRWEB) January 14, 2014 ... company focusing on ultra-sensitive POC diagnostic platforms and novel disease ... their first round of financing netting a total of $690,000. ... outside equity capital in the company. This group of private ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2BioMedomics, Inc. Closes $690K Round of Financing 2
... Focus on Critical Industry Issues -- DUBAI, UAE, September 8, 2010 ... ... ... keyed by longUrl, so we need to grab the first one. for (var r in data.results) { first_result ...
... YORK, Sept. 7 Reportlinker.com announces that a ... catalogue: Biotechnology Pharmaceutical Market in ... Biotechnology Pharmaceutical Market in US ... Pharmaceutical market to grow at a CAGR of ...
... Inc. (OTC Bulletin Board: FCSC ), a ... therapies for aesthetic, medical and scientific applications, announced today ... to its scientific advisory board. In addition to being ... a biotechnology and genetic research expert. Dr. Gruenwald also ...
Cached Biology Technology:Cold Chain MENA 2010 to Focus on Critical Industry Issues 2Cold Chain MENA 2010 to Focus on Critical Industry Issues 3Cold Chain MENA 2010 to Focus on Critical Industry Issues 4Cold Chain MENA 2010 to Focus on Critical Industry Issues 5Cold Chain MENA 2010 to Focus on Critical Industry Issues 6Reportlinker Adds Biotechnology Pharmaceutical Market in US -2013 2Fibrocell Science, Inc. Names Biotechnology and Genetic Research Expert Stefan Gruenwald, M.D., Ph.D., to Scientific Advisory Board 2Fibrocell Science, Inc. Names Biotechnology and Genetic Research Expert Stefan Gruenwald, M.D., Ph.D., to Scientific Advisory Board 3
...
Human Cystatin A MAb (Clone 224705)...
Corticoliberin...
Anti-SDF-1β/PBSF affinity isolated antibody lyophilized powder Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline recombinant human SDF-1β/PBSF expressed in E....
Biology Products: