Navigation Links
Insulin may reduce several inflammatory factors induced by bacterial infection

BUFFALO, N.Y. -- Treating intensive care patients who develop life-threatening bacterial infections, or septicemia, with insulin potentially could reduce their chances of succumbing to the infection, if results of a new preliminary study can be replicated in a larger study.

A paper published online ahead of print in Diabetes Care reports that insulin lowered the amount of inflammation and oxidative stress in study participants who had been injected with a common bacteria, or endotoxin, known as LPS (lipopolysaccharide).

The study was conducted by University at Buffalo endocrinologists at Kaleida Health's Diabetes-Endocrinology Center of Western New York.

LPS, found in the outer membrane of various gram-negative bacteria, is known to increase the ability of the bacteria to cause hemorrhage, necrosis of the kidneys and shock, especially in immune-compromised patients.

The study involved 19 healthy subjects who were injected after an overnight fast with a dose of the endotoxin based on their weight. After the endotoxin injection, 10 participants were infused with insulin (plus dextrose to maintain normal glucose levels), and nine received saline to mimic the insulin infusion.

The infusions continued for six hours following the endotoxin injections. Participants then ate a 900 calorie meal and ate nothing else until the following morning.

Researchers monitored the subjects' temperature, pulse, blood pressure, headaches, body aches and chills for 24 hours following the endotoxin injection. Blood samples were collected one hour before the injection, at the time of injection and at one, two, four, six and 24 hours afterwards.

Monitoring showed that the endotoxin raised body temperature by three degrees -- from 98 to a peak of 101.3 at the four-hour mark, and produced body aches and headaches, which peaked between one and two hours. Results showed that insulin reduced the body-aches score but had no effect on temperature,

In addition, the endotoxin induced a rapid rise in several destructive and inflammatory factors, including reactive oxygen species (free radicals) and products of nitric oxide and fat metabolism. The insulin infusion led to total elimination of several pro-inflammatory factors and to a significant reduction in generation of reactive oxygen species and the products of fat metabolism.

Paresh Dandona, MD, PhD, UB distinguished professor of medicine and senior author on the study, says this study confirms the expectations arising out of the researchers' initial discovery of the anti-inflammatory effect of insulin.

"This study lays the foundation for further studies based on insulin infusion and the normalization of blood glucose concentrations in patients with endotoxemia and septicemia," says Dandona.

"Our endocrinology group demonstrated previously that insulin also has anti-inflammatory and cardioprotective effects in patients who had a heart attack, and we currently are conducting a study on the potential beneficial effects of insulin on acute stroke.

"Clearly, insulin may emerge with roles beyond those conceived when it was discovered in 1921 as a metabolic hormone, and has since been used for the treatment of diabetes to lower and control blood glucose concentrations," Dandona notes.


Contact: Lois Baker
University at Buffalo

Related biology news :

1. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
2. Decreasing insulin resistance prevents obesity-related cardiovascular damage
3. Findings show insulin -- not genes -- linked to obesity
4. Nanodiamonds deliver insulin for wound healing
5. Pitt study finds molecular link between insulin resistance and inflammation
6. Diabetes advance: Researchers find gene that causes resistance to insulin
7. CHEO RI study uses sophisticated genetic engineering to improve insulin-producing beta cells
8. New gene variants associated with glucose, insulin levels, some with diabetes risk
9. Scripps research scientists find new link between insulin and core body temperature
10. Structure of insulins docking point identified
11. Insulin-like signal needed to keep stem cells alive in adult brain
Post Your Comments:
(Date:11/30/2015)... , Nov. 30, 2015  BIOCLAIM announced ... finalist in this year,s Fierce Innovation Awards:  Healthcare Edition, ... FierceHealthIT , FierceHealthcare , ... as a finalist in the category of "Privacy ... --> --> ...
(Date:11/26/2015)... Research and Markets ( ) has ... - Technology and Patent Infringement Risk Analysis" report ... --> Fingerprint sensors using capacitive technology represent ... sensor vendor Idex forecasts an increase of 360% of ... and of the fingerprint sensor market between 2014 and ...
(Date:11/20/2015)... , November 20, 2015 NXTD ... focused on the growing mobile commerce market and creator ... Gino Pereira , was recently interviewed on The ... air on this weekend on Bloomberg Europe , ... . --> NXTD ) ("NXT-ID" or the ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... ... 2015 , ... Global Stem Cells Group Chile ... Central America and abroad for the first Iberoamerican Convention on Aesthetic Medicine, Cosmetology ... Testart will present and discuss new trends in anti-aging stem cell treatments, regenerative ...
(Date:11/30/2015)... ... , ... Global Stem Cells Group announced that its scientific team ... isolating adipose-derived stem cells. The announcement starts a new phase toward launching the simple, ... component of the lipoaspirate obtained from liposuction of excess adipose tissue. , Lipoaspirate, ...
(Date:11/30/2015)... MIAMI (PRWEB) , ... November 30, 2015 , ... ... opening of a new, Good Manufacturing Practice (GMP) 10000 in the Santiago Marriott. ... technologies available, and is operated by a world-class team of qualified medical researchers ...
(Date:11/30/2015)... ... November 30, 2015 , ... Global Stem Cells Group announced the opening ... the cities of Arica and Iquique in northern Chile. The facilities are part of GSCG’s ... most advanced protocols and techniques in stem cell medicine to patients from around the world. ...
Breaking Biology Technology: