Grand Challenges Canada, which is funded by the Government of Canada, today announced $100,000 grants to 51 innovators in 18 low and middle income countries worldwide to pursue bold, creative ideas to tackle health problems in resource-poor countries.
Grants were also announced for 17 Canadian-based projects to be implemented in developing countries.
Among the Canadian-based projects: researchers will mimic rocket technology to propel coagulant nanoparticles into the bloodstream and stop maternal bleeding, a major cause of death in the developing world; test a high-tech Burn Survival Kit that includes a low-cost silver nanotubule dressing making treatment affordable; and develop an HIV infection detector that works in fewer than 5 minutes.
Out-of-the-box projects based overseas include a new trading system in Kenya: seeds and fertilizers for proof of child vaccinations; a $100 kitchen reno to reduce indoor pollution and problem pregnancies in Bangladesh; cultivating disease-fighting prawns in Senegal; creating wealth from human waste in cholera-troubled Haiti; and, in Zambia, anti-diarrhea kits hitching a ride on Coca-Cola's distribution system to get essential medicine to "the ends of the Earth."
The Stars in Global Health program seeks breakthrough, affordable ideas that can be transformative in addressing disease - innovations that can benefit the developing world. A total of more than $7 million will support 68 projects -- 38 in Africa (Benin, Burkina Faso, Cameroon, Ghana (4), Kenya (10), Nigeria, Rwanda (2), Senegal (2), Tanzania (2), Uganda (8), Zambia (4), Zimbabwe and South Africa), 23 in Asia (Afghanistan, Bangladesh (3), China, India (9), Indonesia, Malaysia, Mongolia, Nepal, Pakistan (4), Vietnam), 5 in Latin America / Caribbean (Haiti (3), Guatemala, Nicaragua), and 2 in the Middle East (Jordan, Tunisia).
"Canada works with our like-minded partners throughout the world to leverage our investments in health innovation so they're focused on getting results," said Canadian Foreign Affairs Minister John Baird. "We support Grand Challenges Canada's Stars in Global Health so these innovators can apply their talents and further efforts to make the world a healthier and safer place."
"This is the largest pipeline of bold ideas in global health from innovators worldwide, and shows unequivocally that poor countries can be rich in ideas about how to improve the health of their people," says Dr. Peter A. Singer, CEO of Grand Challenges Canada. "Grand Challenges Canada is proud to support these extraordinary innovators because they will make a difference to so many lives."
Each of the innovators, selected from over 250 applicants, will receive a grant of $100,000 to develop their innovations. If their ideas prove effective, the innovators will be eligible for an additional Grand Challenges Canada scale-up funding of $1 million.
Today's grants include:
Researchers from Antara Global Health Advisors and the Johns Hopkins Bloomberg School of Public Health, working with UNICEF and RuralNet Associates, will study how piggy-backing essential anti-diarrhea kits for infants on the highly developed Coca-Cola supply system in Zambia might improve "last mile delivery" in low and middle-income countries.
The effort is spearheaded by the organization ColaLife and delivered by local partners.
Many maternal and newborn deaths in developing countries could be prevented through better monitoring of blood pressure, hemoglobin and blood sugar levels of pregnant women.
Researchers will design a low-cost, non-invasive wristband for mothers-to-be with built in sensors that can measure and transfer these readings to healthcare providers along with the mother's GPS location.
The sensors will collect information via copper wire and Bluetooth. The data will be processed in a central core, which will process and encrypt the vital sign information, tag the patient's location, and periodically transfer the information to health providers.
"The solution not only addresses a huge gap in maternal and child health, it allows the health system to direct resources to high-risk pregnancies and addressing emergency cases, thus reducing mortality," says Pakistan-based lead researcher Shariq Khoja.
To eliminate persistent pocket areas of Kenya where children are not vaccinated or undervaccinated, researchers will create a barcoded vaccination card redeemable for farm seeds and fertilizer.
Updated each time a child gets a vaccine, the card is taken to one of about 20,000 local agro-vet outlets, where the barcode is scanned using an app on a camera-equipped smartphone. The farmer would then redeem an "agri-credit" for essential farm inputs.
Lead researcher Benson Wamalwa of the University of Nairobi says the program "would powerfully incentivize parents to seek and adhere to their children's immunization schedule even when hard pressed financially to reach a distant vaccination centre.
The idea is a practical solution that would significantly boost small farm productivity and incomes for poor household while safeguarding the general health of children in farming villages through up-to-date immunizations."
The recent cholera outbreak in Haiti heightened both awareness of the problem's cause and demand for better sanitation services -- a tough challenge in environments without reliable running water. Meanwhile, national demand for farm and forest compost is high.
Hoping to capitalize on those twin realities, a Haitian group will build in urban slums the first new $200, waterless "EcoSan" toilets that produce revenue-generating compost, with hopes of inspiring entrepreneurs to replicate the project throughout Haiti and around the world, where 2.5 billion people lack sanitation access.
The project will document the number of toilets built and people receiving sanitation services, quantity of compost produced, sales and the outcomes of tests for pathogens and nutrients.
The International Energy Agency estimates that biomass fuels such as wood and dung will continue providing 30% of global energy in resource-poor settings though 2050.
Exposure to smoke from biomass cooking fuels, however, is known to cause placental dysfunction and is highly associated with low birth-weight babies in developing countries. Part of the solution could be a locally-made, simple prefabricated "$100 kitchen" featuring a clean-combustion stove.
Researchers in Bangladesh will conduct a randomized controlled trial with 430 willing mothers, 2 to 3 months pregnant, half of whom will use the innovative, well-ventilated $100 kitchen with reinforced cement infrastructure, a waste disposal system, and a stove that combusts biofuels with minimal smoke.
WHO projects that globally by 2015 about 2.3 billion adults will be overweight; more than 700 million will be obese -- an epidemic growing fastest in developing countries and leading to diseases like type 2 diabetes, cancers, cardiovascular disease, hypertension and stroke.
In rural northern Nigeria, where mobile phone use is now common (use in Nigeria rose almost 1,300% in 2010-11), health researchers led by Sally Akarolo-Anthony will work with a high-tech firm to create a smartphone app to provide a virtual mentor and online buddy system.
The app will compute a user's metabolic rate and caloric requirement, prompt daily exercise, collect data on activity and eating, offer healthy diet tips (e.g. white vs. brown rice), estimate the daily calorie intake required to meet a weight-loss goal, and monitor change over time.
In Bangladesh, although 79% of 12-23 month old children are fully immunized, coverage remains low (42%-60%) in 22 rural hard-to-reach districts and children living in urban streets. In collaboration with local mobile phone companies, this initiative will establish a computerized data base, auto registration and reminder system related to vaccinations for children living in rural hard-to-reach areas as well as the streets of Bangladesh.
The tool created will register every birth electronically, and obtain their location to help ensure that every child is vaccinated, and ultimately help lower under-five illness and death. Vaccinators' working at the sub-district level will have access to the data base of pregnant and recently delivered women and their mobile phone numbers.
Caregivers and / or birth attendants will be encouraged to register a newborn by voice or text messaging, which will automatically create a file that follows vaccines received and up-coming due dates. Parents will get a reminder text message one day prior to their child's appointment at the vaccination centres.
To control malaria, researchers will install on existing village homes in Kenya a ventilated ceiling made of mats woven by local artisans using local materials and fitted with a small amount of insecticide netting. This will be used to block mosquitoes that access homes through open eaves -- a characteristic of village houses.
The papyrus mat ceilings will be added to the houses of 80 willing villagers (with 80 unmodified homes studied as controls).
Researchers will then assess the impact of the mats on rates of indoor insect bites and expect an approximately 50-90% reduction in malaria prevalence and anaemia and to improve child school attendance.
Researchers in Accra, Ghana, aim to create a simple, accurate, cost effective diagnostic test to the doorsteps of communities endemic with Buruli ulcers - a disease caused by a relative of the bacteria that causes tuberculosis and leprosy and characterized by large ulcers, usually on the legs or arms.
Up to half of patients are left with disabilities that have long-term social and economic impacts. Early diagnosis and treatment are vital but accessing health care is often difficult.
In sub-Saharan Africa, the average cost of surgical treatment per patient is US$780, an amount which far exceeds per capita national government spending on health.
All items needed to diagnose the disease will be packaged into a test kit, including swabs and single step DNA extraction and amplification tools.
Tsetse fly-inflicted African trypanosomiasis (aka "sleeping sickness") is a debilitating and dehumanizing neglected tropical disease whose victims (30,000 in 2009) are typically ostracized. The few therapies available today are toxic with poor patient compliance because they're administered intravenously.
Using genomics, bioinformatics, molecular biology and other modern sciences, Uganda researchers led by Savannah Mwesigwa will test novel ideas for an innovative vaccine to combat the disease in people as well as livestock, the loss of which causes serious economic hardship (3 million cattle killed in 2005 at a loss of $4.5 billion).
Researchers working on lakes in Costa Rica and Nicaragua will establish floating farms to cultivate native aquatic plants, rice and filter-feeding fish in hopes of reducing agricultural water needs and removing excess nutrients in the water by plant uptake.
The aquatic plants (e.g. Azolla, duckweed, water hyacinth, alligator weed, water fern) have high (up to 40% or more) protein content usable as food for humans, fish and livestock. Their use as biofuel is equally valuable. If successfully proven, researchers plan to adapt the technology and technique to sea conditions.
Of the 500,000 hearing impaired babies born every year worldwide, 100,000 are born in India. And in resource-poor settings, hearing impairment often goes undiagnosed until the child is about three years old -- too late for effective care to avoid speech loss and impaired communication.
An innovative, low-cost technique enables even minimally-trained users users to screen babies quickly even in noisy environments.
Researchers will run a safety and efficacy clinical validation on 30 adult subjects with the present prototype. With the next developed prototype, they will collect data from newborns.
They also envision a network of audiologists providing after care, starting with 50 audiologists in India.
"Universal Newborn Hearing Screening has the potential to transform the lives of individuals born with hearing impairment by allowing them to be active participants in the social and economic life of their communities," says lead researcher Nitin Sisodia of Stanford University, USA.
"Additionally, no longer requiring full support from their families, these individuals can become productive members of society, contributing to the economic growth of developing nations."
Proper care of mosquito-borne dengue fever -- which causes headache, muscle and joint pains, and a rash similar to measles -- requires early detection but current diagnostic tests offer results only after 5 days of fever, or they are very expensive and not very accurate.
Researchers in Indonesia, where dengue fever is the most common cause of acute illness requiring hospitalization, will test a new low-cost DNA-based test potentially capable of diagnosis in 5 to 15 minutes, which would significantly reduce fatalities and care costs.
Schistosomiasis is a neglected tropical disease spread by snails that damages internal organs and, in children, impairs growth and cognitive development.
Of the 200 million cases recorded annually, 184 million are in Africa. Another 790 million people are at risk in Africa, Asia and South America.
In Senegal, researchers will try to restore populations of native freshwater prawns, which thrive on the troublesome snails.
Village cooperatives will sell the prawns, raised in controlled, low-density aquaculture operations, thereby improving nutrition while attacking the schistosomiasis problem.
In Uganda's capital Kampala, youth will be paid to collect and sort discarded organic waste and deliver it to a plant for conversion to fertiliser and biogas, to be packaged in bags and canisters. Youths will then help market the products to households and institutions, the biogas canisters offering an affordable alternative to liquified petroleum gas, charcoal and fuel wood.
The urban waste collection effort will unclog drainage systems, reducing water borne diseases and breeding sites for mosquitoes. It will benefit as well the health of ecologically-sensitive Lake Victoria. And, project leaders say, the concept can easily be scaled and transferred to comparable urban areas throughout Africa.
"Canada is enabling bold ideas which can have big impact," said Joseph L. Rotman, Chair of Grand Challenges Canada. "This program is about what can happen if the ideas of early career innovators are vigorously supported. It is about the Government of Canada enabling young innovators in developing countries to solve their own problems."
The 17 Canadian-based research projects receiving $100,000 grants include:
There have already been 436 applications, including 338 from low and middle-income countries, for the next (4th) round of funding under the GCC Stars in Global Health programme.
Grand Challenges Canada is funded by the Government of Canada through the Development Innovation Fund announced in the 2008 Federal Budget.
|Contact: Terry Collins
Sandra Rotman Centre for Global Health