Navigation Links
Insights into the immune system, from the fates of individual T cells
Date:3/20/2013

By charting the differing fates of individual T cells, researchers have shown that previously unpredictable aspects of the adaptive immune response can be effectively modeled. The crucial question: What determines which of the immune system's millions of cells will mobilize to fight an acute infection and which will be held back to survive long-term, forming the basis of the immunological memory? The scientists' findings, published in the journal Science, could have implications for improved immunotherapy and vaccination strategies.

The scientists found that the immediate immune response to an infection or tumor is mounted by a relatively tiny fraction of the so-called CD8+ T cells that are capable of recognizing the associated antigen. These few rapidly expand into giant populations of short-lived T cells targeted at killing infected cells or cancer cells. Meanwhile the vast majority remain in smaller populations geared toward longevity, to help ensure that the immune system will remember the antigen when it appears again in the future.

"Up to now, it was only possible to observe groups of immune cells during the response to an infection," says Prof. Dirk Busch of the Technische Universitaet Muenchen (TUM). "We have developed technology that enables us to observe individual T cells." Together with innovative cell processing technology, the researchers brought theoretical systems biology and clinical expertise to bear on this investigation, a collaboration of TUM, the University of Heidelberg, the Helmholtz Center Munich, the German Cancer Research Center (DKFZ), and the National Center for Infection Research (DZIF).

Marking the threshold of predictability

A single T cell is theoretically capable of generating an adaptive immune response by developing into diverse and expanding populations, fighting the acute infection as well as providing lasting memory for the future. But a fundamental question whether an e
'/>"/>

Contact: Patrick Regan
regan@zv.tum.de
49-016-242-79876
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study offers new insights on invasive fly threatening US fruit crops
2. Pig brain models provide insights into human cognitive development
3. Misplaced molecules: New insights into the causes of dementia
4. Study provides insights into plant evolution
5. Life experiences put their stamp on the next generation: New insights from epigenetics
6. Discovery of sexual mating in Candida albicans could provide insights into infections
7. New insights into the borderline personality brain
8. Study offers new insights into the mechanics of muscle fatigue
9. New insights into how immune system fights atherosclerosis
10. Study offers insights into role of muscle weakness in Down syndrome
11. Basketball teams offer insights into building strategic networks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insights into the immune system, from the fates of individual T cells
(Date:7/10/2014)... inflammatory skin diseases psoriasis* and eczema** are similar in ... base their decision on which treatment should be selected ... samples. A team of researchers at the Helmholtz Zentrum ... now analyzed the molecular processes that occur in both ... for the first time to gain a detailed understanding ...
(Date:7/9/2014)... pivotal in the development of cancer, viral infection and ... question about one of the most widely-researched proteins in ... of thousands of research papers and millions of pounds ... in Professor Sir Philip Cohen,s laboratory at the University ... is activated. The results are published today ...
(Date:7/9/2014)... LAFAYETTE, Ind. - Regulated deer hunts in Indiana state ... from decades of damage caused by overabundant populations of ... team led by Michael Jenkins, associate professor of forest ... Resources policy of organizing hunts in state parks has ... and wildflowers rendered scarce by browsing deer. , ...
Breaking Biology News(10 mins):New diagnostic test to distinguish psoriasis from eczema 2Research reveals how key controller protein is switched on 2Hunting gives deer-damaged forests in state parks a shot at recovery 2
... The American Psychological Association, the largest psychological ... "Distinguished Scientific Award for Early Career Contribution to ... Research Institute at the University of Veterinary Medicine, ... Range,s ground-breaking research on animal cognition and will ...
... the researchers to see an aspect of light that humans ... sensitive to polarized light, many reef dwelling animals are but ... studies of reef communities. Thanks to generous support provided ... team of researchers from the Ecology of Vision Laboratory in ...
... of rare, endemic species in the Central Andes remain ... climate change, according to a Duke University-led international study. ... particularly vulnerable to changes in the environment or climate. ... percent of the areas with high numbers of these ...
Cached Biology News:Dancing with wolves -- prestigious award goes to a scientist at the Vetmeduni Vienna 2Capturing an octopus-eye view of the Great Barrier Reef 280 percent of 'irreplaceable' habitats in Andes unprotected 2
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, April ... Location: Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... nonprofit organization solely dedicated to finding a cure for hepatitis ... worldwide, will host its annual Crystal Ball on Friday, April ...
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... based on the products of cells grown under simulated ... an international license agreement with Suneva Medical, Inc. for ... media (CCM). , This agreement is an ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... This release is available in German ... say, on plastic foils, have excellent potential to lower ... called "balance-of-system" cost, thus enabling affordable solar electricity in ... on polymer films have been lacking behind in performance ...
... Generex Biotechnology Corporation,s (OTCBB: GNBT) ( www.generex.com ) wholly-owned ... that its lead drug candidate AE37, a novel HER-2/neu-targeted ... of breast cancer, is featured in the October 2011 ... titled "A New Ally Against Cancer" by Eric von ...
... NEW YORK, Sept. 21, 2011 Reportlinker.com announces ... in its catalogue: Separation ... http://www.reportlinker.com/p0619255/Separation-Systems-for-Commercial-Biotechnology.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biotechnology THIS REPORT ... the U.S. market for separation systems for commercial ...
Cached Biology Technology:How to produce flexible CIGS solar cells with record efficiency 2Antigen Express' AE37 Cancer Vaccine Featured in Scientific American 2Antigen Express' AE37 Cancer Vaccine Featured in Scientific American 3Antigen Express' AE37 Cancer Vaccine Featured in Scientific American 4Separation Systems for Commercial Biotechnology 2Separation Systems for Commercial Biotechnology 3Separation Systems for Commercial Biotechnology 4Separation Systems for Commercial Biotechnology 5Separation Systems for Commercial Biotechnology 6Separation Systems for Commercial Biotechnology 7Separation Systems for Commercial Biotechnology 8Separation Systems for Commercial Biotechnology 9Separation Systems for Commercial Biotechnology 10Separation Systems for Commercial Biotechnology 11
... fixative useful for routine procedures. Hollandes contains ... and will decalcify small bone specimens. Tissue ... stained successfully with most stains, and the ... blood cell membranes and cosinophil and endocrine ...
... fixative useful for routine procedures. Hollandes contains ... and will decalcify small bone specimens. Tissue ... stained successfully with most stains, and the ... blood cell membranes and cosinophil and endocrine ...
Chicken polyclonal antibody to Glutathione-S-Transfrease (GST)...
... Acuity is the complete enterprise microarray informatics platform ... analysis. Buy Acuity once and use it forever ... Tools for Quality Acuity has all the ... from your data, from quality control statistics and ...
Biology Products: