Navigation Links
Insights into the immune system, from the fates of individual T cells
Date:3/20/2013

By charting the differing fates of individual T cells, researchers have shown that previously unpredictable aspects of the adaptive immune response can be effectively modeled. The crucial question: What determines which of the immune system's millions of cells will mobilize to fight an acute infection and which will be held back to survive long-term, forming the basis of the immunological memory? The scientists' findings, published in the journal Science, could have implications for improved immunotherapy and vaccination strategies.

The scientists found that the immediate immune response to an infection or tumor is mounted by a relatively tiny fraction of the so-called CD8+ T cells that are capable of recognizing the associated antigen. These few rapidly expand into giant populations of short-lived T cells targeted at killing infected cells or cancer cells. Meanwhile the vast majority remain in smaller populations geared toward longevity, to help ensure that the immune system will remember the antigen when it appears again in the future.

"Up to now, it was only possible to observe groups of immune cells during the response to an infection," says Prof. Dirk Busch of the Technische Universitaet Muenchen (TUM). "We have developed technology that enables us to observe individual T cells." Together with innovative cell processing technology, the researchers brought theoretical systems biology and clinical expertise to bear on this investigation, a collaboration of TUM, the University of Heidelberg, the Helmholtz Center Munich, the German Cancer Research Center (DKFZ), and the National Center for Infection Research (DZIF).

Marking the threshold of predictability

A single T cell is theoretically capable of generating an adaptive immune response by developing into diverse and expanding populations, fighting the acute infection as well as providing lasting memory for the future. But a fundamental question whether an e
'/>"/>

Contact: Patrick Regan
regan@zv.tum.de
49-016-242-79876
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study offers new insights on invasive fly threatening US fruit crops
2. Pig brain models provide insights into human cognitive development
3. Misplaced molecules: New insights into the causes of dementia
4. Study provides insights into plant evolution
5. Life experiences put their stamp on the next generation: New insights from epigenetics
6. Discovery of sexual mating in Candida albicans could provide insights into infections
7. New insights into the borderline personality brain
8. Study offers new insights into the mechanics of muscle fatigue
9. New insights into how immune system fights atherosclerosis
10. Study offers insights into role of muscle weakness in Down syndrome
11. Basketball teams offer insights into building strategic networks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Insights into the immune system, from the fates of individual T cells
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
(Date:4/14/2015)... Conn. , April 14, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... been nominated for the 2015 New York Design Awards ... The Design100, New York City Design Awards are part ... based on over 2,500 ratings from the marketplace, industry ...
(Date:4/8/2015)... April 8, 2015  Infinisource, a leading provider ... and Morpho, a leading supplier of biometric identification ... the market,s most advanced biometrically-enabled time clock, the ... time clock is setting a bold, new standard ... for the small and mid-size employer. When connected ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... eaten fish, gone for a boat ride or even taken a ... commodity. But just how valuable? That,s always been a tough question ... clean water against societal needs that compromise it, such as the ... ability to do so has been greatly enhanced by a new ...
... LAGOS, Nigeria Fifteen science academies of Africa issued ... the African scientific community to intensify its study of ... of scientific information to understanding climate change has been ... to step up their observation, modeling, and analyses of ...
... The role that new low carbon technologies can play ... greenhouse gas emissions and moving towards a green economy ... in-depth reports into core areas of innovation., These three ... buildings, industrial emissions efficiency, and domestic buildings and are ...
Cached Biology News:Study offers new tool for incorporating water impacts into policy decisions 2New low carbon TINA reports 2
(Date:5/21/2015)... NJ (PRWEB) May 21, 2015 Patent ... a method for diagnostic or therapeutic imaging within a ... apparatus uses an endoscope having a low cost, single-use ... USPTO filing date was October 18, 2013 and the ... The technology enables the physician to customize the lighting ...
(Date:5/21/2015)... May 21, 2015 As part of ... Center (BDWMC), Sun Health Foundation funded a $3.25 million ... inpatient pharmacy with the most up-to-date features and technology. ... 2. The pharmacy's 45 staff members will begin moving ... space in the coming days. , The current ...
(Date:5/21/2015)... - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: ... on the development of autologous cell therapies, announced ... Society for Cellular Therapy (ISCT) on RepliCel,s autologous ... a Phase 1/2 clinical trial.  The presentation, taking ... PM to 7:00 PM local time, will review ...
(Date:5/21/2015)... 21, 2015 Tunnell Consulting, ... firm as senior statistician and Principal, a position to ... in the management and analysis of complex and large ... industries. , “We’re delighted to have Julia join the ... analytics,” said Dr. Philippe Cini, Group Vice President and ...
Breaking Biology Technology:IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2
... 11, 2012 Dr. Richard Dolinar, chairman of the ... of concern that the U.S. Food and Drug Administration ... the U.S. drug market in prepared testimony for the ... FDA,s recent draft guidelines for the development of biosimilar ...
... Calif., May 10, 2012 Aviir Diagnostic Laboratory has ... testing as a participating provider with Stratose Network and ... About Stratose A true pioneer of ... OPPN, PlanCare America, 4MOST Health, Qualident and KeyClaims) works ...
... 9, 2012 A monumental discovery that provides the promise ... at large was announced this morning in London during ... National Children,s Leukemia Foundation, a leading non-profit organisation in ... teams in the United States and Israel have discovered. ...
Cached Biology Technology:Alliance for Safe Biologic Medicines Chairman Urges FDA to Ensure that Patient Safety is the Cornerstone of Biosimilar Pathway 2Aviir Laboratories Announce National Agreement with Stratose 2Aviir Laboratories Announce National Agreement with Stratose 3Founder of National Children's Leukemia Unveiled Non-Embryonic Stem Cell Treatment Promising Cure for Cancer at GIL 2012: Europe 2Founder of National Children's Leukemia Unveiled Non-Embryonic Stem Cell Treatment Promising Cure for Cancer at GIL 2012: Europe 3
Anti-ADAM-12 (Meltrin Alpha); amino terminal region; rabbit host...
Dual Color Mouse anti-Human Anti-Kappa FITC/CD19 PE Class: Antibody Product Group: Immunogluobulin...
Ly-49C and Ly-49I Biotin Anti-Mouse clone 5E6, Isotype Mouse IgG 2a , kappa, 0.1 mg Consult technical datasheet for details....
Shh Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Biology Products: