Navigation Links
Insight into the dazzling impact of insulin in cells
Date:5/21/2013

Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.

The breakthrough study, conducted by Sean Humphrey and Professor David James from Sydney's Garvan Institute of Medical Research, is now published in the early online edition of the prestigious journal Cell Metabolism.

First discovered in 1921, the insulin hormone plays a very important role in the body because it helps us lower blood sugar after a meal, by enabling the movement of sugar from the blood into cells. Until now, although scientists have understood the purpose of insulin at a broad level, they have struggled to understand exactly how it achieves its task.

The latest analytical devices called mass spectrometers now provide the tool that has been missing the means of looking into the vastly complex molecular maze that exists in every single cell in the human body.

These powerful devices have opened up a field known as 'proteomics', the study of proteins on a very large scale. Proteins represent the working parts of cells, using energy to perform all essential functions such as muscle contraction, heartbeat or even memory.

Each cell houses multiple copies of between 10,000 and 12,000 protein types, which communicate with each other using various methods, the most common of which is a process known as 'phosphorylation'. Phosphate molecules are deliberately added to proteins in order to convey information, or else change the protein's function.

Each of the protein types in a cell has up to 20 potential 'phosphorylation sites', regions to which a phosphate molecule can be added. This pushes the total number of possible cell states from one moment to the next into the billions.

The authors discovered 37,248 phosphorylation sites on 5,705 different proteins, 15% of which changed in response to i
'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New insights into cloud formation
2. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
3. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
4. Discovery offers insight into treating viral stomach flu
5. Fine-scale analysis of the human brain yields insight into its distinctive composition
6. Chimpanzee ground nests offer new insight into our ancestors descent from the trees
7. Battle of the sexes offers evolutionary insights
8. Analysis of speed of Greenland glaciers gives new insight for rising sea level
9. Mice with big brains provide insight into brain regeneration and developmental disorders
10. Maps of Miscanthus genome offer insight into grass evolution
11. Songbirds learning hub in brain offers insight into motor control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... suburb , Observations and mapping by seismologists at ... days after the August 24 earthquake in northern California ... much damage in the region, according to a post ... Geophysical Union. , From this week,s ... Our Curiosity , Selecting where the next Mars ...
(Date:9/2/2014)... Field Museum will present the prestigious Parker/Gentry Award to ... to biodiversity conservation awareness. The Parker/Gentry Award is given ... team or organization whose efforts have had a significant ... whose actions can serve as a model to others. ... environmental science and conservation news website that draws more ...
(Date:9/2/2014)... of lithographic limestone is well known as a ... that area (for example, Archaeopteryx). Now, for the ... the French equivalent of these outcrops - discoveries ... known water treader. , Despite the abundance of ... have been obtained from the Late Kimmeridgian equivalents ...
Breaking Biology News(10 mins):This week From AGU: California earthquake, future Mars rovers, models underestimate ozone 2Exceptionally well preserved insect fossils from the Rhône Valley 2
... pattern takes over the traditional rectangular patchwork of fields in ... In the dry Texas panhandle near the town of Dalhart, ... that improves water distribution to fields. It was invented by ... pumping water from the center of the field through a ...
... - Genomatix is proud to announce that it has ... at Hannover Messe, the world,s biggest technology trade show. ... for products of a high technological, economic, ecological or ... panel of 30 experts including professors and specialized journalists. ...
... scientists at the University of Copenhagen show that a ... the intercellular signalling that controls the growth and development ... carbohydrate may result in the uninhibited cell growth that ... cancer. The results have just been published in the ...
Cached Biology News:NASA's Landsat satellites see Texas crop circles 2Fruit flies provide new knowledge about uninhibited cell growth 2
(Date:9/2/2014)... Biological aggregation is a critical, yet often overlooked ... we systematically characterize the effects of aggregation on ... contrast of magnetic iron oxide nanoparticles (IONPs), including ... quasi-fractal descriptions. While aggregation is shown to produce ... we also present a new method to quantify ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 Press attending ... ways to take advantage of the people and events ... schedule below are available throughout the day. Additionally, we ... with POET and DSM representatives as well as representatives ... requests is appreciated. , Please remember to RSVP ...
(Date:9/2/2014)... 2014 Myriant Corporation, a global ... a distribution agreement with Azelis Group, a specialty ... bio-succinic acid in the Nordics, Benelux, France, Iberia, ... in the industrial and base chemicals markets. , ... a far-reaching chemical portfolio with extensive distribution networks ...
(Date:9/2/2014)... - Oncothyreon Inc. (Nasdaq: ONTY ) announced today that ... will present at the Rodman & Renshaw 16 th ... on Tuesday, Sept. 9, 2014 at 2:05 p.m. Eastern. ... presentation will be accessible by visiting the Oncothyreon website ... About Oncothyreon Oncothyreon is a biotechnology ...
Breaking Biology Technology:Accounting for biological aggregation in heating and imaging of magnetic nanoparticles 2Press agenda for Project LIBERTY Grand Opening 2Press agenda for Project LIBERTY Grand Opening 3Press agenda for Project LIBERTY Grand Opening 4Press agenda for Project LIBERTY Grand Opening 5Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2
... - Some of extraterrestrial expert Frank Drake s ... of 300 at the University of Wisconsin-Madison Feb. 19, ... in Mountain View, Calif., explained the reasons why he ... potential methods of communicating with far-off civilizations. , ,I ...
... DEMO and in the weeks since, I've been asked many ... networking. There is, of course, one very practical reason: No ... 2004 timeframe. But that's the easy out. , ,As I've ... fundamental sense. Without a clear avenue to revenue that returns ...
... majority of economists and corporate executives believe that globalization ... it causes. But there is a substantial difference between ... faire attitude towards how this trend affects businesses, communities ... assistant professor of public policy at Rochester Institute of ...
Cached Biology Technology:Alien expert illuminates audience on extraterrestrial possibilities 2Social Networks Revisited 2Social Networks Revisited 3Preservation not protectionism 2Preservation not protectionism 3
... Human Cytokeratin TYPE II Reacts with ... Including epidermal cell keratin of 86 and ... 67kD. Broad keratin reactivity is found on ... Immunogen: Human epidermal cells ...
... Detection System is intended for use in ... by an in-house validated in vitro nucleic ... interest. • The ... hybridization capture assay designed to detect amplified ...
Mouse Anti-Human Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4 Monoclonal Antibody Family: New...
Polymerase (RNA) II (DNA directed) polypeptide L...
Biology Products: