Navigation Links
Insight into the dazzling impact of insulin in cells
Date:5/21/2013

Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.

The breakthrough study, conducted by Sean Humphrey and Professor David James from Sydney's Garvan Institute of Medical Research, is now published in the early online edition of the prestigious journal Cell Metabolism.

First discovered in 1921, the insulin hormone plays a very important role in the body because it helps us lower blood sugar after a meal, by enabling the movement of sugar from the blood into cells. Until now, although scientists have understood the purpose of insulin at a broad level, they have struggled to understand exactly how it achieves its task.

The latest analytical devices called mass spectrometers now provide the tool that has been missing the means of looking into the vastly complex molecular maze that exists in every single cell in the human body.

These powerful devices have opened up a field known as 'proteomics', the study of proteins on a very large scale. Proteins represent the working parts of cells, using energy to perform all essential functions such as muscle contraction, heartbeat or even memory.

Each cell houses multiple copies of between 10,000 and 12,000 protein types, which communicate with each other using various methods, the most common of which is a process known as 'phosphorylation'. Phosphate molecules are deliberately added to proteins in order to convey information, or else change the protein's function.

Each of the protein types in a cell has up to 20 potential 'phosphorylation sites', regions to which a phosphate molecule can be added. This pushes the total number of possible cell states from one moment to the next into the billions.

The authors discovered 37,248 phosphorylation sites on 5,705 different proteins, 15% of which changed in response to i
'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New insights into cloud formation
2. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
3. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
4. Discovery offers insight into treating viral stomach flu
5. Fine-scale analysis of the human brain yields insight into its distinctive composition
6. Chimpanzee ground nests offer new insight into our ancestors descent from the trees
7. Battle of the sexes offers evolutionary insights
8. Analysis of speed of Greenland glaciers gives new insight for rising sea level
9. Mice with big brains provide insight into brain regeneration and developmental disorders
10. Maps of Miscanthus genome offer insight into grass evolution
11. Songbirds learning hub in brain offers insight into motor control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Cleveland: A type of immune cell widely believed ... Alzheimer,s disease and multiple sclerosis (MS), can actually ... and may slow the progression of neurodegenerative diseases, ... the online journal Nature Communications . , ... Chair of the Department of Neurosciences at Cleveland ...
(Date:7/21/2014)... (Toronto) As part of a multinational, collaborative effort, ... (CAMH) have helped identify over 100 locations in the ... in what is the largest genomic study published on ... in Nature , point to biological mechanisms and ... new approaches to treating the disorder, which has seen ...
(Date:7/21/2014)... Millar , a professor of entomology and ... at the University of California, Riverside, has been ... International Society of Chemical Ecology ( ISCE ). , ... is the society,s highest honor. It is awarded ... chemical ecology, the study of chemicals that mediate interactions ...
Breaking Biology News(10 mins):Cleveland Clinic researchers discover neuroprotective role of immune cell 2International team sheds new light on biology underlying schizophrenia 2International team sheds new light on biology underlying schizophrenia 3UC Riverside entomologist receives international honor for chemical ecology contributions 2
... called exons, which code for the synthesis of proteins, ... predict the different regions in a new and unannotated ... today. Now researchers at the Indian Institute of Technology ... identify DNA introns and exons an order of magnitude ...
... created a new type of miniature pump activated by body ... fermentation., The micropump contains bakers yeast and sugar in a ... placed on the skin, the body heat and the added ... small amount of carbon dioxide gas. The gas pushes against ...
... Consumers nurture romantic ideas of nature by engaging in ... to a new study in the Journal of ... "Nature is often considered the ideal place to ... culture in contexts as diverse as surfing, tropical island ...
Cached Biology News:Body heat, fermentation drive new drug-delivery 'micropump' 2Trouble in paradise: Does nature worship harm the environment? 2
(Date:7/22/2014)... New York (PRWEB) July 22, 2014 ... world. The heat produced by controlled fission chain reaction ... This steam pressure is used to drive a power- ... approximately 19% of the world’s total electricity production. Nuclear ... to several under construction, planned and proposed nuclear reactor ...
(Date:7/22/2014)... 22, 2014 Two new members were ... Directors at its annual Shareholders Meeting on June 13: ... of The PFM Group, and Stephen T. Zarrilli, President ... announced the election of Michael A. DiPiano, Managing General ... and Richard P. Jaffe, Esq., of Duane Morris LLP, ...
(Date:7/22/2014)... China , 22 juli 2014 BGI ... BGI, ,s wereld grootste organisatie op het gebied van ... service ten behoeve van hele menselijke genoomsequentie via het ... In 2013 acquireerde BGI Complete Genomics, ... staat vanwege de in eigen beheer ontwikkelde sequentietechnologieën met ...
(Date:7/22/2014)... , July 22, 2014  The Broad Institute ... from philanthropist Ted Stanley aimed at ... new treatments based on molecular understanding to hundreds ... The Stanley commitment – the largest ... for scientific research in general – will support ...
Breaking Biology Technology:Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 2Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 3Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3BGI Tech introduceert service op gebied van hele menselijke exoomsequencing op geavanceerd Complete Genomics-platform 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 3$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 4$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 5$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 6$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 7$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 8$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 9$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 10
... eResearchTechnology, Inc. (ERT), (Nasdaq: ERES ), ... pharmaceutical, biotechnology, and medical device industries, announced the successful ... of CareFusion Corporation (CRS).  CRS is a leading provider ... and also offers cardiac safety and ePRO services.  The ...
... BOZEN, Sud-Tirol, Italy , ... that its joint venture Health Robotics South East Asia ... separate,government-sponsored projects to deliver CytoCare-made accurate and sterile,oncology patient ... , respectively. Health,Robotics, CytoCare is the first and only ...
... ... “road map” defining all aspects of the future 110-acre Livermore Valley Open Campus development. ... and real estate development planning, as well as maintenance and operations planning. , ... San Francisco, CA (PRWEB) ...
Cached Biology Technology:ERT Closes the Acquisition of the Research Services Division of CareFusion Corporation 2ERT Closes the Acquisition of the Research Services Division of CareFusion Corporation 3Health Robotics South East Asia Wins two key Cancer Therapy Outsourcing Projects in Malaysia and Thailand 2Health Robotics South East Asia Wins two key Cancer Therapy Outsourcing Projects in Malaysia and Thailand 3Flad Architects Awarded Livermore Valley Open Campus Master Plan 2
... Clamp One can operate as a Voltage ... Conductance (Dynamic) Clamp in electrophysiology research applications. ... as conventional analog equipment. This amazing instrument ... the capabilities of Digital Signal Processing (DSP) integrated ...
... System facilitates the display of custom peptide ... as coat protein fusions, creating a physical ... encoding DNA sequence. Peptide ligands for a ... by the straightforward method of biopanning. The ...
... A key to successful cell culture or ... composition during the process, and make rapid ... composition. Nova BioProfile Chemistry Analyzers provide immediate ... in cell culture and fermentation media. BioProfile ...
... Vtg in plasma from juvenile or male fish ... disrupting chemicals (EDCs) with estrogenic effects in fish. ... test for the estrogenic effects of EDCs in ... a double-antibody immunometric (sandwich) EIA for analyzing Vtg ...
Biology Products: