Navigation Links
Insight into DNA reprogramming during egg and sperm cell development
Date:12/6/2012

Scientists at the Babraham Institute have gained a new understanding of when and how the DNA in developing egg and sperm cells is 'reset', in preparation for making a new embryo. It is well known that small chemical groups can be added to DNA to alter gene activity, these modifications to the DNA are acquired during development in the womb and throughout adult life and can arise from changes in environment. Most of these modifications are removed in immature egg and sperm cells to 'reset' the DNA and to erase any 'environmental memory', but some remain. Decoding this reprogramming has major implications for our understanding of development and how these modifications can be inherited from one generation to another.

All the cells in the body of one individual have the same DNA sequence (genome) and it is how the DNA sequence is interpreted that results in the formation of different cell types, for example different genes can be switched on and off. Inactive genes often have a small chemical modification, called a methyl group, added to them outside the coding sequence which promotes this regulation. This study, published today (6 December) in the journal Molecular Cell, is the first genome-wide study to look at what happens to the methyl groups during early stages of egg and sperm cell (primordial germ cell) development. This type of research, investigating modifications to the DNA which do not alter the underlying DNA sequence, is called epigenetics.

Dr Stefanie Seisenberger, lead author from the Babraham Institute, which receives strategic funding from the Biotechnology and Biological Sciences Research Council (BBSRC), explained, "We produced a high resolution map showing the location and timing of methyl group removal from primordial germ cell DNA. We discovered that the majority of demethylation occurred much earlier than people previously thought and this has allowed us to shed light on the process of methyl group removal in mammal
'/>"/>

Contact: Dr Anja Drozd
anja.drozd@babraham.ac.uk
44-012-234-96206
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related biology news :

1. New insights into cloud formation
2. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
3. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
4. Discovery offers insight into treating viral stomach flu
5. Fine-scale analysis of the human brain yields insight into its distinctive composition
6. Chimpanzee ground nests offer new insight into our ancestors descent from the trees
7. Battle of the sexes offers evolutionary insights
8. Analysis of speed of Greenland glaciers gives new insight for rising sea level
9. Mice with big brains provide insight into brain regeneration and developmental disorders
10. Maps of Miscanthus genome offer insight into grass evolution
11. Songbirds learning hub in brain offers insight into motor control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... nanoparticle form could help reduce side effects by targeting ... scientists have developed nanoparticles that deliver one or two ... design particles that can carry any more than that ... devised a new way to build such nanoparticles, making ... drugs. In a paper published in the Journal ...
(Date:4/15/2014)... become clear that the genetic code is far ... the well-known building blocks adenine, cytosine, guanine, and ... Scientists now assume that the newly discovered nucleic ... information that extends and complements the genetic code. ... extend the standard alphabet," explained Professor Mark Helm ...
(Date:4/15/2014)... Rosemont, IL (April 15, 2014) New research ... Journal of the American College of Nutrition shows ... exercise or as part of a weight-loss or weight-maintenance ... body composition. , The meta-analysis included 14 randomized ... When researchers analyzed those weight loss studies that used ...
Breaking Biology News(10 mins):Targeting cancer with a triple threat 2Targeting cancer with a triple threat 3German Research Foundation approves new priority program in the life sciences 2New meta-analysis builds on the power of whey protein for improved body composition 2New meta-analysis builds on the power of whey protein for improved body composition 3
... Terrace, Ill., March 8, 2010 Americans recognize things need ... Sam,s efforts to overhaul what is included in their food ... are individually responsible for making the right food choices to ... be successful, according to a new survey by FoodMinds. ...
... the fractious debate on the existence of God and ... the discussion. Taking a perspective rooted in evolutionary biology ... (Prometheus Books, $25) renowned anthropologist Lionel Tiger and pioneering ... is its purpose? How did it arise? What is ...
... problems have to be fed intravenously. There moreover, exist systems ... Mr Iaki Irastorza, paediatrician at the Cruces hospital in Bilbao, ... children were treated at the Great Ormond Street Children,s Hospital ... highly novel PhD thesis at the University of the Basque ...
Cached Biology News:Americans want Uncle Sam's help putting healthy foods on their dinner table 2Which came first: Religion or the brain? 2First time research on long-term consequences of intravenous nutrition on children's health 2First time research on long-term consequences of intravenous nutrition on children's health 3
(Date:1/15/2014)... Canada (PRWEB) January 15, 2014 ... regulatory perspectives on nonclinical and clinical safety assessment ... countries to guide a path for biosimilar drug ... the demonstration of biosimilarity with regards to quality, ... specific aspects of biosimilar drug development and registration, ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains ... of these latent viruses is the Epstein Barr Virus ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease ... theory, a study found that RA patients have high ... , What is Microcompetition? , Dr. Hanan Polansky discovered ...
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 ... Therapy, an experimental new therapy for the treatment of ... tailor-made for their unique tinnitus frequency, and over a ... , AudioNotch has previously provided Notched Sound Therapy in ... AudioNotch is pleased to announce to release of a ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine ... cells grown under simulated embryonic conditions, today announced ... agreement with Suneva Medical, Inc. for physician-dispensed aesthetic ... (CCM). , This agreement is an ... Suneva Medical, through which Suneva has exclusively licensed ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... Based on the clinical success,of its facet replacement ... has expanded its executive management team and established,its ... Massachusetts,allows us to consolidate our operations in one ... gives us access to a wealth of,talent in ...
... Winners of 2008 R&D 100 Awards Now Online, ... the,finalists for the 8th Annual Innovator of the Year ... individuals who exemplify the,ideals of R&D in academia, industry, ... facilitated online with ten finalists,-- five scientists and five ...
... pleased to announce that Dr. Francis Stoessel, a leading ... will be the Keynote Speaker in the Process Safety ... ... Columbia, MD (PRWEB) October ...
Cached Biology Technology:Facet Solutions Establishes Corporate Headquarters and Expands Executive Team 22008 R&D Innovator of the Year & Scientist of the Year Finalists Announced 2
... analysis kit for 10 chips provides the ... analysis with the Experion automated electrophoresis system. ... 3 x 520 microliters Pro260 gel, 45 ... (10-260 kD), 400 microliters Pro260 sample buffer, ...
... original Gene Pulser apparatus and accessory modules the ... in the Gene Pulser II system, which features ... Gene Pulser II system has the dual advantages ... range of settings to target specific cell types ...
Experion Pro260 chips are the microfluidic chips used to perform protein analysis with the Experion automated electrophoresis system. Each chip has the capacity to run 10 protein samples. Supplied as...
... Pro260 reagents and supplies, for 10 ... sufficient to perform protein analysis with ... electrophoresis system. Supplied are 3 x ... Pro260 stain, 60 microliters Pro260 ladder ...
Biology Products: