Navigation Links
Innovative drug-dispensing contact lens delivers glaucoma medication continuously for a month
Date:12/8/2013

BOSTON (Dec. 9, 2013) For nearly half a century, contact lenses have been proposed as a means of ocular drug delivery that may someday replace eye drops, but achieving controlled drug release has been a significant challenge. Researchers at Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology, Boston Children's Hospital, and the Massachusetts Institute of Technology are one step closer to an eye drop-free reality with the development of a drug-eluting contact lens designed for prolonged delivery of latanoprost, a common drug used for the treatment of glaucoma, the leading cause of irreversible blindness worldwide.

"In general, eye drops are an inefficient method of drug delivery that has notoriously poor patient adherence. This contact lens design can potentially be used as a treatment for glaucoma and as a platform for other ocular drug delivery applications," said Joseph Ciolino, M.D, Mass. Eye and Ear cornea specialist and lead author of the paper.

The contacts were designed with materials that are FDA-approved for use on the eye. The latanoprost-eluting contact lenses were created by encapsulating latanoprost-polymer films in commonly used contact lens hydrogel. Their findings are described online and will be in the January 2014 printed issue of Biomaterials.

"The lens we have developed is capable of delivering large amounts of drug at substantially constant rates over weeks to months," said Professor Daniel Kohane, director of the Laboratory for Biomaterials and Drug Delivery at Boston Children's Hospital.

In vivo, single contact lenses were able to achieve, for one month, latanoprost concentrations in the aqueous humor that were comparable to those achieved with daily topical latanoprost solution, the current first-line treatment for glaucoma.

The lenses appeared safe in cell culture and animal studies. This is the first contact lens that has been shown to release drugs for this long in animal models.

The newly designed contact lens has a clear central aperture and contains a drug-polymer film in the periphery, which helps to control drug release. The lenses can be made with no refractive power or with the ability to correct the refractive error in near sided or far sided eyes.

"A non-invasive method of sustained ocular drug delivery could help patients adhere to the therapy necessary to maintain vision in diseases like glaucoma, saving millions from preventable blindness," Dr. Ciolino said.

Earlier versions of this lens were described in the popular press in the Boston Globe, Scientific America, The Economist, CNN.com, and other media outlets.


'/>"/>

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
617-573-4170
Massachusetts Eye and Ear Infirmary
Source:Eurekalert

Related biology news :

1. Bruin Biometrics, LLC Awarded CE Mark for the SEM Scanner, an Innovative Diagnostic Tool to Detect Pressure Induced Tissue Damage
2. Chair Mats of Glass Company Clearly Innovative Announces the Launch of 20 New Dealers in the Midwest
3. Innovative MIT study estimates extent to which air pollution in China shortens human lives
4. AAOS awards recognize innovative orthopaedic research
5. Unlikely partners create innovative product for college biology
6. International space station plays host to innovative infectious disease research
7. Innovative uses of nanotechnology in food and agriculture
8. Mussels inspire innovative new adhesive for surgery
9. MVI and Inovio partner to develop malaria vaccines using innovative vaccine delivery tech
10. NIH awards Penn scientists $10 million over 5 years for innovative research on single cells
11. Summer camp yields innovative apps
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2017)... HANOVER, Germany , March 20, 2017 At ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the ... Japan is this year,s CeBIT partner country. At the largest ... important biometrics in use: fingerprint, face and iris recognition as well as ... ...
(Date:3/13/2017)... Future of security: Biometric Face Matching software  ... ... DERMALOGs Face Matching enables to match face pictures against each other or against ... (PRNewsFoto/Dermalog Identification Systems) ... Matching" is the fastest software for biometric Face Matching on the market. The ...
(Date:3/7/2017)... -- Brandwatch , the leading social intelligence company, today announces ... to uncover insights to support its reporting, help direct future campaigns, ... leading youth charity will be using Brandwatch Analytics social listening and ... understanding of the topics and issues that are a priority for ... "Until ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... MA (PRWEB) , ... March ... ... Group ( WMFTG ) has unveiled its innovative Quantum peristaltic pump with ... peristaltic innovation, Quantum sets the new standard for high-pressure feed pumps in ...
(Date:3/22/2017)... , March 22, 2017  Personal Genome ... its cancer testing contract with the U.S. Department ... tumor profiling assay with the company,s new CancerSELECT ... comprehensive, clinically actionable pan-cancer profiling test that includes ... assess potential patient response to checkpoint inhibitor immunotherapies. ...
(Date:3/20/2017)... ... March 20, 2017 , ... HOLLOWAY AMERICA, ... recently announced it will debut a brand new pressure vessel, the intelliVesselâ„¢, at ... controlled by a touch screen panel and features other revolutionary operations that promote ...
(Date:3/20/2017)... ... March 20, 2017 , ... Park Systems, a leader in Atomic Force ... March 24, 2017 from 5-7pm at their Santa Clara facility that will include craft ... Senior Researcher, Dr. Tae-Gon Kim. , Dr. Tae-Gon Kim, Senior researcher at imec Belgium ...
Breaking Biology Technology: