New Rochelle, NY, July 13, 2010Improved delivery methods and better testing systems are needed to advance promising gene therapy strategies for treating prostate cancer, according to a series of review articles in Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc (www.liebertpub.com). The articles and an accompanying editorial are available free online at www.liebertpub.com/hum
Prostate cancer is one of the most common types of cancer affecting men in the U.S. and is the second leading cause of cancer death among men, after lung cancer. Among the most recent treatment strategies being tested against prostate cancer is gene therapy, in which a gene product intended to destroy the tumor cells or to stimulate the patient's immune system to fight the cancer is delivered to the tumor, typically using a viral delivery vector. The most common approach uses an adenovirus as the delivery vector and has been shown to be quite safe.
However, it is still not clear which genes, viral vectors, or strategies are optimal to ensure targeted delivery of the genes to the tumor cells, and uptake by the tumor, to achieve the most effective, most potent, and safest treatment that can lead to a cure for prostate cancer. Stefan Kochanek, from the University of Ulm, Germany, and Bernd Gnsbacher, from the Technical University of Munich, Germany, present their views on the need for developing and testing new and innovative approaches in the editorial entitled, "Prostate Cancer Gene Therapy: Attempts to Innovate."
Three review articles in the issue explore various aspects of this evolving field and advances that will make it possible to translate new gene therapy techniques from research to testing in human patients. Ellen Schenk and colleagues from Erasmus Medical Center, The Netherlands, and Uppsala University, Sweden, representing the GIA
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Mary Ann Liebert, Inc./Genetic Engineering News